To be or not to be vaccinated: The risk of MS or NMOSD relapse after COVID-19 vaccination and infection

Stastna, Dominika; Menkyová, Ingrid; Drahota, Jiří; Hrnčiarová, Tereza; Havrdová, Eva; Vachová, Marta; Andělová, Michaela; Kleinová, Pavlína; Kovářová, Ivana; Krasulová, Eva; Preiningerová, Jana Lízrová; Nováková, Iveta; Novotná, Klára; Novotná, Martina; Nytrová, Petra; Pavlickova, J.; Srpová, Barbora; Storey, Katerina; Tichá, Veronika; Týblová, Michaela; Uher, Tomáš; Vodehnalová, Karolína; Horáková, Dana

doi:10.1016/j.msard.2022.104014

Cited by 20 publications

(25 citation statements)

References 30 publications

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“…Molecular mimicry of SARS-CoV2 antigens and neurological self-antigens is another potential mechanism. It was reported that both natural SARS-CoV-2 infection and SARS-CoV-2 vaccination can induce the formation of AQP-4 Ab and lead to newly diagnosed NMOSD, or it can also trigger a relapse in patients who already had an established diagnosis [5,[10][11][12][13]. Of note, the postimmunization NMOSD cases are not limited to a certain type or certain company-made vaccine [10].…”

Section: Discussionmentioning

confidence: 99%

“…It was reported that both natural SARS-CoV-2 infection and SARS-CoV-2 vaccination can induce the formation of AQP-4 Ab and lead to newly diagnosed NMOSD, or it can also trigger a relapse in patients who already had an established diagnosis [5,[10][11][12][13]. Of note, the postimmunization NMOSD cases are not limited to a certain type or certain company-made vaccine [10]. These literatures suggest that the shared antiviral immune response between natural infection and vaccinations may play a role in the NMOSD pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

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Investigation of the Effect of the Fear of COVID-19 on School Refusal in terms of Depression, Anxiety, Social Functioning and Academic Resilience

Karaca¹

2022

J Neurol Psychol

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Background: Development of autoimmune neurological disorders after Coronavirus Disease 2019 (COVID-19) has been reported. Though many cases of multiple sclerosis developing after COVID-19 are present in current literature, Neuromyelitis Optica Spectrum Disorder (NMOSD) is much rarer sequela of the disease.Methods: Two cases that meet the international consensus diagnostic criteria for NMOSD were encountered at a regional hospital in West Texas in the same month. Both were preceded by acute SARS-CoV-2 infection and developed newly diagnosed NMOSD with Aquaporin-4 Protein Antibody seropositivity.Results: Case 1 was a 28-year-old Hispanic female who presented with opsoclonus and ophthalmoplegia; Case 2 was a 20-year-old African American female who presented with transverse myelitis. Both patients had no neurological co morbidities or symptoms prior to SARS-CoV-2 infection. Neither of them was vaccinated for COVID-19, and both were of non-Caucasian ethnicity. They presented with a typical features including younger onset, ocular presentation of opsoclonus, negative neuroimaging, no response to steroids, and relapse after a short interval. Conclusion: New developments of NMOSD in previously healthy individuals can be a neurological sequela of COVID-19, especially among unvaccinated individuals. The correlation and pathophysiology of NMOSD after COVID-19 are not fully understood, but molecular mimicry of the virus and cytokine storm are postulated mechanisms. Additional observational studies are needed to further explore the correlation between acute COVID-19 infection and NMOSD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Investigation of the Effect of the Fear of COVID-19 on School Refusal in terms of Depression, Anxiety, Social Functioning and Academic Resilience

Karaca¹

2022

J Neurol Psychol

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“…Another paper reported a significant increase of relapses in MS patients, especially in females of young age, which also occurred after COVID-19 disease. Even in this study, the data relative to SARS-CoV-2 infections refer to the first waves (from 1 March 2020 to October 2021) [ 51 , 52 ].…”

Section: Safety Of Covid-19 Vaccines In People With Autoimmunity and ...mentioning

confidence: 99%

Safety of COVID-19 Vaccines in Patients with Autoimmune Diseases, in Patients with Cardiac Issues, and in the Healthy Population

2023

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The coronavirus disease 2019 (COVID-19) has been a challenge for the whole world since the beginning of 2020, and COVID-19 vaccines were considered crucial for disease eradication. Instead of producing classic vaccines, some companies pointed to develop products that mainly function by inducing, into the host, the production of the antigenic protein of SARS-CoV-2 called Spike, injecting an instruction based on RNA or a DNA sequence. Here, we aim to give an overview of the safety profile and the actual known adverse effects of these products in relationship with their mechanism of action. We discuss the use and safety of these products in at-risk people, especially those with autoimmune diseases or with previously reported myocarditis, but also in the general population. We debate the real necessity of administering these products with unclear long-term effects to at-risk people with autoimmune conditions, as well as to healthy people, at the time of omicron variants. This, considering the existence of therapeutic interventions, much more clearly assessed at present compared to the past, and the relatively lower aggressive nature of the new viral variants.

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“…The question of causality is yet to be resolved. The article from the Prague cohort in this issue is the first large-scale investigation to evaluate the risk of relapse of MS after vaccination compared to the likelihood of deterioration after Covid-19 infection (Stastna et al, 2022).…”

mentioning

confidence: 99%

“…The current study (Stastna et al, 2022) is novel as it describes the probability of MS relapse after mRNA-vaccines. It is strengthened by the fact that the nationwide immunisation programme in Czech Republic took place at the same time and the cohort was closely monitored before and after vaccination.…”

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confidence: 99%

Vaccine hesitancy in people with multiple sclerosis

Lechner‐Scott

Davis²,

Hawkes³

et al. 2022

Multiple Sclerosis and Related Disorders

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To be or not to be vaccinated: The risk of MS or NMOSD relapse after COVID-19 vaccination and infection

Cited by 20 publications

References 30 publications

Investigation of the Effect of the Fear of COVID-19 on School Refusal in terms of Depression, Anxiety, Social Functioning and Academic Resilience

Investigation of the Effect of the Fear of COVID-19 on School Refusal in terms of Depression, Anxiety, Social Functioning and Academic Resilience

Safety of COVID-19 Vaccines in Patients with Autoimmune Diseases, in Patients with Cardiac Issues, and in the Healthy Population

Vaccine hesitancy in people with multiple sclerosis

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