To be or not to be - Decoding the Trabecular Meshwork Cell Identity
Alice Tian,
Hasna Baidouri,
Sangbae Kim
et al.
Abstract:The trabecular meshwork within the conventional outflow apparatus is critical in maintaining intraocular pressure homeostasis.In vitrostudies employing primary cell cultures of the human trabecular meshwork (hTM) have conventionally served as surrogates for investigating the pathobiology of TM dysfunction. Despite its abundant use, translation of outcomes fromin vitrostudies toex vivoand/orin vivostudies remains a challenge. Given the cell heterogeneity, performing single-cell RNA sequencing comparing primary … Show more
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