To Assess Efficacy and Safety of Intravenous Dexmedetomidine and Propofol as Sedative and Analgesic With Their Hemodynamic Effects Among Patients Undergoing Tympanoplasty Under Monitored Anaesthetic Care

Abstract

Background: Due to its analgesic properties,cooperative sedation and lack of respiratory depression,Dexmedetomidine is increasingly being used as a sedative for monitored anaesthesia care. The present study was planned to compare propofol and DexmedetomidineMaterials and methods: for analgesic, sedative and hemodynamic effects in tympanoplasty under local anaesthesia under monitored anesthesia care.Two groups with 39 patients in dexmedetomidine group(D) and 37 patients in propofol group(P) were taken. All the patients were in the age group of 18 to 60 years belonging to ASA status I or II. Results: The mean values of intraoperative respiratory rate and oxygen saturation at different intervals among two groups were statistically not signicant (P value of >0.05).The mean systolic blood pressure was found to be lower in patients of group P as compared to group D with p value of < 0.05.Majority of the patients were satised in group D as compared to group P(P-0.0012).Patients receiving Dexmedetomidine had a better surgical eld as compared to patient of group P(p< 0.05).Majority of the patients (40.54%) in group P required fentanyl requirement intraoperatively as compared to group D (10.25%)(p valve 0.002) Dexmedetomidine and propofol providesConclusion: adequate sedation but the use of propofol is associated with more requirements of rescue analgesia and poor patient and surgeon satisfaction.These results suggest that dexmedetomidine provides adequate sedation with analgesia and good surgical and patient comfort without any adverse effects for patients undergoing tympanoplasty under local anaesthesia.