To ablate or not: A proposal regarding nomenclature

Alam, Murad; Dover, Jeffrey S.; Arndt, Kenneth A.

doi:10.1016/j.jaad.2010.02.041

Cited by 13 publications

(7 citation statements)

References 5 publications

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“…The term “nonablative” was first coined to describe treatment that selectively damages the dermal tissue while sparing the epidermis. In contrast to ablative lasers, nonablative fractional devices are associated with minimal side effects and downtime [36, 37].…”

Section: Laser and Intense Pulsed Light Therapiesmentioning

confidence: 99%

Concomitant Use of Hyaluronic Acid and Laser in Facial Rejuvenation

et al. 2019

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Background Facial aging is a process that involves many different changes. Therefore, in many patients, it may be necessary to perform a combined treatment. Botulinum toxin A and dermal fillers are the two most popular nonsurgical cosmetic procedures performed globally to treat age-associated changes. However, there are not many studies reporting the concomitant use of dermal fillers and laser technology for facial rejuvenation. This review aims to assess the concomitant use of dermal hyaluronic acid (HA) fillers and laser technology for facial rejuvenation. Methods The present updated consensus recommendations are based on the experience and opinions of the authors and on a literature search. Results If a combined procedure (HA and light treatments) is to be performed, on the same day, the panel recommends starting always with the light treatments, avoiding skin manipulations after having injected HA. To customize the therapeutic management, it is crucial to establish a precise diagnosis of the photodamage and loss of volumes suffered by the patients. Conclusions The currently available scientific evidence about the combined use of HA fillers and laser–radiofrequency–intense pulsed light (laser/RF/IPL) is limited and encompasses mainly small and nonrandomized studies. Nevertheless, most of these studies found that, on average, the concomitant use (same day) of laser and HA fillers for facial rejuvenation represents an effective and safe strategy which improves clinical results and patient’s satisfaction. Future well-designed clinical studies are needed regarding the effectiveness and safety of combination filler/laser treatments. Level of Evidence IV This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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Section: Laser and Intense Pulsed Light Therapiesmentioning

confidence: 99%

Concomitant Use of Hyaluronic Acid and Laser in Facial Rejuvenation

et al. 2019

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“…Ablative and nonablative lasers have been developed to treat photoaged skin . Ablative treatments destroy or remove the epidermis, while nonablative treatments keep the epidermis intact . The fully ablative CO 2 laser is considered the most effective laser treatment option for most photodamaged tissues.…”

Section: Introductionmentioning

confidence: 99%

Randomized, double‐blind, phase III clinical study of a novel nanotechnological topical anesthetic formulation containing lidocaine 25 mg/g and prilocaine 25 mg/g (nanorap) in skin phototypes I–III patients with ablative fractional CO₂ laser treatment indication in the forehead

Gobbato

Magalhaes

et al. 2019

Lasers Surg Med

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Background and Objectives Nanotechnology may increase the speed of penetration into the skin. This study evaluated the efficacy, safety, and pharmacokinetics of a novel topical anesthetic nanocapsule formulation (2 g) containing 2.5% lidocaine and 2.5% prilocaine (nanorap—test formulation) compared to placebo (control formulation) in skin types I–III patients of both sexes submitted to the ablative fractional CO2 laser treatment. Methods The patients (n = 120) included in this double‐blind, single‐center, randomized trial, received topical application of 2 g of the test formulation (50 mg lidocaine + 50 mg prilocaine) and placebo on the forehead region. Efficacy was assessed as pain sensation in four quadrants of each side of the forehead using a visual analogue scale immediately (0 min) and at 30, 60, and 90 minutes after laser application compared to placebo. The safety and tolerability of the test product were evaluated based on the occurrence of systemic adverse events as well as the occurrence of immediate and late skin reactions. Pharmacokinetic evaluation was performed in plasma of eight patients using a validated LC‐MS/MS method for drugs quantification. Results Nanorap induced a clinically significant reduction in the pain assessment at all evaluated times (57.2%, 41.6%, 38.6%, and 37.3% at 0, 30, 60, and 90 minutes after drug application, respectively. Mean values of Cmax were 14.20 and 5.36 ng/ml and tmax were 3.5 and 1.8 hour for lidocaine and prilocaine, respectively. No systemic adverse events were observed. Conclusion The nanorap formulation demonstrated a clinically and statistically significant efficacy providing analgesia after the ablative fractional CO2 laser therapy in the investigated patients, when compared to placebo. The product also presented good safety and tolerability. Lasers Surg. Med. © 2019 Wiley Periodicals, Inc.

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“…Nonablative and ablative lasers can be used to either remove or perforate skin in a fine pinpoint pattern, with resulting neocollagenesis; only a fraction of the skin is treated with each treatment, and a series of treatments are required to treat the entire affected surface. 2 It has been suggested that neocollagenesis and improvement of acne scars can also be achieved using needle rollers, 3 which use a mechanical, macroscopic approach to induce small epidermal and dermal perforations. Needle rollers are cylindrical objects with a circumferential array of perpendicularly placed needles and a rotational axle affixed to a handle.…”

mentioning

confidence: 99%