TNFα-mediated tissue damage in mouse footpads primed with mycobacterial preparations

Attiyah, R. Al; Moreno, Carlos; Rook, G.A.W.

doi:10.1016/0923-2494(92)80041-i

Cited by 18 publications

(7 citation statements)

References 17 publications

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“…Indeed, studies report the involvement of IL‐4 in tissue damage in mycobacterial infection in mice [31]. Separate investigations indicate that, while TNF‐ α exhibits beneficial effects in term of enhancing mycobacterium tuberculosis control in the presence of a predominant Th1 response, a combination of Th2 cytokines and TNF‐ α causes a significant increase in tissue damage [32–34].…”

Section: Discussionmentioning

confidence: 99%

T lymphocyte phenotypic profile in lung segments affected by cavitary and non-cavitary tuberculosis

Mazzarella

Bianco

Perna

et al. 2003

Clinical and Experimental Immunology

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SUMMARYClinical manifestations of pulmonary tuberculosis (TB) may depend on a complex interaction between the host and the pathogen. Clinical outcomes of pulmonary tuberculosis are variable, ranging from asymptomatic lifelong infection to parenchymal lung destruction, resulting in cavitary lesions. To investigate the hypothesis that local cellular immune response may affect presentation and outcome in tuberculosis, we performed bronchoalveolar lavage (BAL) in lung segments affected by cavitary and non-cavitary tuberculosis. We then correlated the type of cellular response at the level of the involved lung segments with clinical evolution in terms of cavity formation. We found alveolar lymphocytosis in patients with both cavitary and non-cavitary pulmonary tuberculosis, with increased CD4 + lymphocytes in patients with non-cavitary pulmonary tuberculosis. A predominant Th1 immune response has been observed in non-cavitary patients, while cavitary involved segments exhibit the presence of Th2 lymphocyte subsets. These data, while confirming the importance of Th1-type CD4 + cells and IFN-g in effective cellular immunity in active pulmonary tuberculosis, also suggest that the presence of Th2 lymphocytes may contribute to tissue necrosis phenomena associated with cavitary evolution of pulmonary tuberculosis. Our observations indicate the importance of the type of local immune response at the site of disease in the development of different clinical characteristics and outcome in pulmonary tuberculosis.

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Section: Discussionmentioning

confidence: 99%

T lymphocyte phenotypic profile in lung segments affected by cavitary and non-cavitary tuberculosis

Mazzarella

Bianco

Perna

et al. 2003

Clinical and Experimental Immunology

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“…The critical role of T cells has been demonstrated in the mouse footpad model, in which the destructive effect of TNF-␣ could be abrogated by a single dose of anti-CD4 just before TNF-␣ administration. 34 Rook and HernandezPando 35 have argued that the tissue-damaging potential of TNF-␣ is determined by the presence of local T cell cytokines, with tissue damage only occurring where there is either mixed Th1/Th2 or Th0 cytokine activity.…”

Section: Discussionmentioning

confidence: 99%

The detection of Mycobacterium leprae protein and carbohydrate antigens in skin and nerve from leprosy patients with type 1 (reversal) reactions.

Lockwood¹,

Colston²,

Khanolkar-Young³

2002

The American Journal of Tropical Medicine and Hygiene

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Abstract. Type 1 (reversal) reactions are the most common immunological complications of leprosy. These episodes of delayed hypersensitivity produce severe local immunopathology and ultimately nerve damage. To date, the Mycobacterium leprae antigens associated with type 1 reactions have not been identified. Using monoclonal antibodies to defined protein and carbohydrate M. leprae epitopes (65, 35 and 28 kd and lipoarabinomannan [LAM]) in a two-step immunoperoxidase staining technique, M. leprae antigens were demonstrated in skin and nerve biopsies from patients in reversal reaction. Antigen presence and staining patterns were similar in skin and nerve lesions, implying that the pathological processes are similar in the two sites. Antigens were present both in macrophages and Schwann cells but also as a diffuse extracellular infiltrate associated with the inflammatory infiltrate. The 28-kd antigen was present most strongly and may be a potential candidate antigen for initiating type 1 reactions. LAM also stained strongly and persisted after treatment. The possible roles of LAM and 65 kd in the cellular events of type 1 reactions are discussed.

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“…Furthermore, Shwartzman [ 73 ] found that rabbits previously injected with Gram-negative bacteria in the skin developed haemorrhagic necrosis at the initial site of injection following an intravenous injection of the same bacteria 24 h later. This reaction may be explained, in part, by T-cell mediated MTB-specific immune responses, given that depleting CD4 + T-cells in pre-immunised mice inhibited this reaction [ 74 ]. This study also highlighted an important role for TNF-α in perpetuating necrosis [ 74 ].…”

Section: Mediators Of Lung Damage and Dysfunction In Tbmentioning

confidence: 99%

Tuberculosis and lung damage: from epidemiology to pathophysiology

et al. 2018

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A past history of pulmonary tuberculosis (TB) is a risk factor for long-term respiratory impairment. Post-TB lung dysfunction often goes unrecognised, despite its relatively high prevalence and its association with reduced quality of life. Importantly, specific host and pathogen factors causing lung impairment remain unclear. Host immune responses probably play a dominant role in lung damage, as excessive inflammation and elevated expression of lung matrix-degrading proteases are common during TB. Variability in host genes that modulate these immune responses may determine the severity of lung impairment, but this hypothesis remains largely untested. In this review, we provide an overview of the epidemiological literature on post-TB lung impairment and link it to data on the pathogenesis of lung injury from the perspective of dysregulated immune responses and immunogenetics.

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TNFα-mediated tissue damage in mouse footpads primed with mycobacterial preparations

Cited by 18 publications

References 17 publications

T lymphocyte phenotypic profile in lung segments affected by cavitary and non-cavitary tuberculosis

T lymphocyte phenotypic profile in lung segments affected by cavitary and non-cavitary tuberculosis

The detection of Mycobacterium leprae protein and carbohydrate antigens in skin and nerve from leprosy patients with type 1 (reversal) reactions.

Tuberculosis and lung damage: from epidemiology to pathophysiology

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