TNFA expression level changes observed in response to the Wingate Anaerobic Test in non-trained and trained individuals

Maciejewska-Skrendo, Agnieszka; Mieszkowski, Jan; Kochanowicz, Andrzej; Stankiewicz, Błażej; Świtała, Katarzyna; Assis, Gilmara Gomes de; Kecler, Katarzyna; Tarnowski, Maciej; Sawczuk, Marek

doi:10.29359/bjhpa.11.3.01

Cited by 8 publications

(7 citation statements)

References 33 publications

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“…In a situation in which the accumulation of exercise load is very high, and decreased athletic performance is induced, the presence of muscle injury and increased inflammation processes are also observed. It is called 'overtraining' and may lead to increased immune system activity with elevated secretion of inflammatory factors [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

cfDNA Changes in Maximal Exercises as a Sport Adaptation Predictor

Humińska-Lisowska

Mieszkowski

Kochanowicz

et al. 2021

Genes

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Changes of circulating free plasma DNA (cfDNA) are associated with different types of tissue injury, including those induced by intensive aerobic and anaerobic exercises. Observed changes are dependent from induced inflammation, and thus it may be a potential marker for athletic overtraining. We aimed to identify the response of cfDNA to different types of exercise, with association to exercise intensity as a potential marker of exercise load. Fifty volunteers (25 athletes and 25 physically active men) were assigned to the study and performed maximal aerobic (Bruce test) and anaerobic (Wingate Anaerobic Test) test. Blood samples for cfDNA analysis were collected at four time-points: before, 2–5 min after, 30 min after and 60 min after each type of maximal physical activity. The two-way ANOVA revealed a significant effect of group factor on serum cfDNA concentrations (32.15% higher concentration of cfDNA in the athletes). In turn the results of the post hoc test for the interaction of the repeated measures factor and the group showed that while the concentration of cfDNA decreased by 40.10% in the period from 30 min to 60 min after exercise in the control group, the concentration of cfDNA in the group of athletes remained at a similar level. Our analysis presents different responses depending on the intensity and duration of exercise. Our observations imply that formation of cfDNA is associated with response to physical activity but only during maximal effort.

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Section: Introductionmentioning

confidence: 99%

cfDNA Changes in Maximal Exercises as a Sport Adaptation Predictor

Humińska-Lisowska

Mieszkowski

Kochanowicz

et al. 2021

Genes

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“…These novel data are predicted to advance precision sport sciences considerably by facilitating optimally tailored training programs based on an individual’s molecular profile, which includes their genomic information [ 28 , 29 ]. Knowledge regarding the biochemical, physiological, and genetic factors that affect muscle performance is key to achieving success in sports [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

TTN Variants Are Associated with Physical Performance and Provide Potential Markers for Sport-Related Phenotypes

Leońska-Duniec

Borczyk

Piechota

et al. 2022

IJERPH

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TTN encodes the third myofilament, titin, which plays structural, mechanical, regulatory, and developmental roles in sarcomeres. The aim of this research was to determine the interaction between novel and previously described TTN variants and athletic performance, as well as competition level, in Caucasians. Firstly, 100 athletes and 47 controls were recruited, and whole-genome sequencing was performed. Secondly, 348 athletes (108 endurance, 100 sprint/power, 140 mixed-sport athletes) and 403 volunteers were included, and real-time PCR was performed. We found a significant overrepresentation of the rs10497520 CT and TT genotypes in the sprint/power athlete group (95% CI, 1.41–3.66, p = 0.0013). The rs10497520 T carriers were 2.17 times more likely to become sprint/power athletes (95% CI 1.35–3.49, p = 0.0021). We also found that the likelihood of having the TT genotype was higher for the highly elite and sub-elite sprint/power athletes. Possessing at least one TAA (rs10497520, rs55837610, rs72648256) haplotype resulted in an increase in the log-odds ratio by 0.80 (p = 0.0015), 1.42 (p = 0.003), and 0.77 (p = 0.044) for all, highly elite, and sub-elite sprint/power athletes, respectively. We demonstrated that harbouring the rs10497520 T allele, individually and in a haplotype combination, increased the chance of being an elite sprint/power athlete, indicating that this allele may be favourable for sprint/power performance.

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“…Additionally, the molecular mechanisms of change in response to physical activity in the human body is still unknown. Among the many factors influencing systemic response to exercise training are age, gender, diseases, individual predispositions, volume, intensity and frequency of physical activity, food intake, and others [4,36].…”

Section: Discussionmentioning

confidence: 99%

AMPD1 C34T Polymorphism (rs17602729) Is Not Associated with Post-Exercise Changes of Body Weight, Body Composition, and Biochemical Parameters in Caucasian Females

Leońska-Duniec

Maculewicz

Humińska-Lisowska

et al. 2020

Genes

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Background: The C34T polymorphism (rs 17602729) in adenosine monophosphate deaminase 1 gene (AMPD1) is associated with muscular energy metabolism in exercise. However, the role of its potential modifying impact on exercise-induced changes in obesity related parameters is unknown. The aim of the study was to determine if the C34T polymorphism influences the effects of an exercise training. Methods: This study examines a group of one hundred and sixty-eight, young, non-obese Caucasian women in Poland who took part in a 12-week aerobic training program to determine the impact of allele and genotype distribution on training outcomes. Results: A two-way analysis of variance ANOVA was conducted assuming a dominant model by pooling rare homozygotes and heterozygotes (TT + CT, n = 79) and comparing against common homozygotes (CC, n = 89). Our results showed that the AMPD1 C34T polymorphism was not related with selected parameters in study group. After completing the 12-week training program, a wide array of parameters (body mass, body mass index, fat mass, free fat mass, total body water) were significantly changed in the study participants with the exception of AMPD1 genotypes, among whom no significant changes were observed. Conclusions: The results did not confirm that harboring the rs 17602729 T allele influences the effects of the training program.

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TNFA expression level changes observed in response to the Wingate Anaerobic Test in non-trained and trained individuals

Cited by 8 publications

References 33 publications

cfDNA Changes in Maximal Exercises as a Sport Adaptation Predictor

cfDNA Changes in Maximal Exercises as a Sport Adaptation Predictor

TTN Variants Are Associated with Physical Performance and Provide Potential Markers for Sport-Related Phenotypes

AMPD1 C34T Polymorphism (rs17602729) Is Not Associated with Post-Exercise Changes of Body Weight, Body Composition, and Biochemical Parameters in Caucasian Females

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