TNF-αG-308A polymorphism is associated with insulin resistance: a meta-analysis

Wang, H.G.; Yang, Junpeng; Han, Huijian; Xu, Feng; Bian, Yuan; Zhang, H.; Wang, J.L.

doi:10.4238/2015.january.26.11

Cited by 9 publications

(10 citation statements)

References 42 publications

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“…Based on these data, the present meta-analysis showed no significant correlation between the TNF-α 308G/A polymorphism and PCOS. However, previous meta-analyses have demonstrated this variation to be associated with increased susceptibility to hepatocellular carcinoma, gastric cancer, and type 2 diabetes mellitus (Hu et al, 2014;Rokkas et al, 2014;Zhao et al, 2014;Wang, et al, 2015). Such inconsistent results may have been caused by the TNF-α 308G/A polymorphism performing divergent roles in different cell types or tissues.…”

Section: Discussionmentioning

confidence: 70%

Meta-analysis of the correlation between the TNF-α308G/A polymorphism and polycystic ovary syndrome

et al. 2016

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ABSTRACT. Previous studies have suggested that the tumor necrosis factor alpha (TNF-α) gene 308G/A polymorphism may be associated with polycystic ovary syndrome (PCOS) risk. However, this relationship is controversial. The present meta-analysis aimed to evaluate the correlation between the TNF-α 308G/A polymorphism and susceptibility to PCOS. A systematic electronic search of PubMed and Embase databases was conducted using specific inclusion criteria. Summary odds ratios (ORs) and 95% confidence intervals (95%CIs) were calculated, and all statistical analyses were performed using STATA 12.0. The results of our meta-analysis showed no significant association between the TNF-α 308G/A polymorphism and PCOS risk ( sequence variation may be not related to PCOS susceptibility. Further large and well-designed studies are needed to confirm this conclusion.

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Section: Discussionmentioning

confidence: 70%

Meta-analysis of the correlation between the TNF-α308G/A polymorphism and polycystic ovary syndrome

et al. 2016

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“…Tumor Necrosis Factor-α (TNFα) is another key proinflammatory cytokine in the early stages of the inflammatory response ( 26 ). Similar to IL-1, elevated TNFα levels have been observed in crevicular fluid and saliva of patients with active peri-implantitis lesions and shown to directly correlate with the degree of clinical severity of peri-implant disease ( 27 ).…”

Section: Resultsmentioning

confidence: 99%

“…Similar to IL-1, elevated TNFα levels have been observed in crevicular fluid and saliva of patients with active peri-implantitis lesions and shown to directly correlate with the degree of clinical severity of peri-implant disease ( 27 ). TNFα, among other direct and indirect effects, has a strong capacity to stimulate bone resorption by promoting cell differentiation from the monocyte-macrophage line to osteoclasts, inducing the maturation of osteoclasts and enhancing their resorptive activity ( 26 , 27 ).…”

Section: Resultsmentioning

confidence: 99%

Current understanding of genetic polymorphisms as biomarkers for risk of biological complications in implantology

et al. 2018

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BackgroundIn the last decade, multiple studies have been published that analyze the relationship between the risk of experiencing biological complications with implants and the presence of certain types of genetic polymorphisms. In the present report, we analyze the controversies that have arisen from this important area of investigation and synthesize the most prominent aspects of knowledge related to this possible etiopathogenic relationship.Material and MethodsFor this review, the biomedical databases PubMed-Medline, SciELO, and DOAJ were used. Different search strategies were employed, from which 298 articles initially emerged. After refinement of the search, 55 articles published between 2002 and 2018 were finally selected based on relevance.ResultsIn certain population groups, there is evidence to support that about a dozen polymorphisms could in some way be related to biological complications in implantology. Indeed, the results may vary according to the ethnic origin of the population studied. Most of the published investigations are initial studies reporting small sample sizes and utilizing different study group homogenization methods. We are still at a preliminary stage of our understanding and development with regard to these types of biomarkers. The interesting results identified indicate that new investigations will be necessary to eliminate the biases observed in some studies and to homogenize the research groups. In order to clarify the controversies surrounding the current knowledge in this field, we believe that it will be necessary to employ larger study groups and search for possible synergistic effects between different polymorphisms. Key words:Polymorphism, genetic markers, peri-implantitis, biological complication, dental implant.

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“…Several polymorphisms have been identified in the promoter region of the TNFA gene [ 23 , 24 ]; however, to date, −308G → A polymorphism (rs1800629) has been the best characterized genetic variant in relation to metabolic and cardiovascular disease outcomes [ 24 – 26 ]. The TNFA -308G → A polymorphism has been linked with BMI and obesity [ 13 , 27 ], where A allele carriers have been shown to have higher BMI [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Association of the tumor necrosis factor-alpha promoter polymorphism with change in triacylglycerol response to sequential meals

Jackson

Ryan

et al. 2015

Nutr J

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BackgroundReported associations between Tumor Necrosis Factor-alpha (TNFA) and the postprandial triacylglycerol (TAG) response have been inconsistent, which could be due to variations in the TNFA gene, meal fat composition or participant’s body weight. Hence, we investigated the association of TNFA polymorphism (−308G → A) with body mass index (BMI) and postprandial lipaemia and also determined the impact of BMI on the association of the polymorphism with postprandial lipaemia.MethodsThe study participants (n = 230) underwent a sequential meal postprandial study. Blood samples were taken at regular intervals after a test breakfast (t = 0, 49 g fat) and lunch (t =330 min, 29 g fat) to measure fasting and postprandial lipids, glucose and insulin. The Metabolic Challenge Study (MECHE) comprising 67 Irish participants who underwent a 54 g fat oral lipid tolerance test was used as a replication cohort. The impact of genotype on postprandial responses was determined using general linear model with adjustment for potential confounders.ResultsThe -308G → A polymorphism showed a significant association with BMI (P = 0.03) and fasting glucose (P = 0.006), where the polymorphism explained 13 % of the variation in the fasting glucose. A 30 % higher incremental area under the curve (IAUC) was observed for the postprandial TAG response in the GG homozygotes than A-allele carriers (P = 0.004) and the genotype explained 19 % of the variation in the IAUC. There was a non-significant trend in the impact of BMI on the association of the genotype with TAG IAUC (P = 0.09). These results were not statistically significant in the MECHE cohort, which could be due to the differences in the sample size, meal composition, baseline lipid profile, allelic diversity and postprandial characterisation of participants across the two cohorts.ConclusionsOur findings suggest that TNFA -308G → A polymorphism may be an important candidate for BMI, fasting glucose and postprandial TAG response. Further studies are required to investigate the mechanistic effects of the polymorphism on glucose and TAG metabolism, and determine whether BMI is an important variable which should be considered in the design of future studies.Trial registration NCT01172951.

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TNF-αG-308A polymorphism is associated with insulin resistance: a meta-analysis

Cited by 9 publications

References 42 publications

Meta-analysis of the correlation between the TNF-α308G/A polymorphism and polycystic ovary syndrome

Meta-analysis of the correlation between the TNF-α308G/A polymorphism and polycystic ovary syndrome

Current understanding of genetic polymorphisms as biomarkers for risk of biological complications in implantology

Association of the tumor necrosis factor-alpha promoter polymorphism with change in triacylglycerol response to sequential meals

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