TNF-α, TGF-β and NO relationship in sera from tuberculosis (TB) patients of different severity

Fiorenza, Gladys; Rateni, Liliana; Farroni, Miguel A.; Bogué, Cristina; Dlugovitzky, Diana

doi:10.1016/j.imlet.2004.09.008

Cited by 48 publications

(26 citation statements)

References 15 publications

(19 reference statements)

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“…Moreover, positive correlations between CSF neutrophil numbers and cytokine concentrations suggest a significant role for neutrophils in the immunopathogenesis. In the early stage of disease in HIV-infected individuals, neutrophils may accumulate at infected sites, and overproduction of cytokines (particularly TNF-α) may be responsible for tissue damage and contribute to pathology [20–23]. …”

Section: Discussionmentioning

confidence: 99%

Leukotriene A4 Hydrolase Genotype and HIV Infection Influence Intracerebral Inflammation and Survival From Tuberculous Meningitis

Thuong

Heemskerk

Tram

et al. 2017

The Journal of Infectious Diseases

150

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Background.Tuberculous meningitis (TBM) is the most devastating form of tuberculosis, yet very little is known about the pathophysiology. We hypothesized that the genotype of leukotriene A4 hydrolase (encoded by LTA4H), which determines inflammatory eicosanoid expression, influences intracerebral inflammation, and predicts survival from TBM.Methods.We characterized the pretreatment clinical and intracerebral inflammatory phenotype and 9-month survival of 764 adults with TBM. All were genotyped for single-nucleotide polymorphism rs17525495, and inflammatory phenotype was defined by cerebrospinal fluid (CSF) leukocyte and cytokine concentrations.Results. LTA4H genotype predicted survival of human immunodeficiency virus (HIV)–uninfected patients, with TT-genotype patients significantly more likely to survive TBM than CC-genotype patients, according to Cox regression analysis (univariate P = .040 and multivariable P = .037). HIV-uninfected, TT-genotype patients had high CSF proinflammatory cytokine concentrations, with intermediate and lower concentrations in those with CT and CC genotypes. Increased CSF cytokine concentrations correlated with more-severe disease, but patients with low CSF leukocytes and cytokine concentrations were more likely to die from TBM. HIV infection independently predicted death due to TBM (hazard ratio, 3.94; 95% confidence interval, 2.79–5.56) and was associated with globally increased CSF cytokine concentrations, independent of LTA4H genotype.Conclusions. LTA4H genotype and HIV infection influence pretreatment inflammatory phenotype and survival from TBM. LTA4H genotype may predict adjunctive corticosteroid responsiveness in HIV-uninfected individuals.

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Section: Discussionmentioning

confidence: 99%

Leukotriene A4 Hydrolase Genotype and HIV Infection Influence Intracerebral Inflammation and Survival From Tuberculous Meningitis

Thuong

Heemskerk

Tram

et al. 2017

The Journal of Infectious Diseases

150

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“…The same behavior is observed in contacts of patients with tuberculosis and in treated and cured PTB patients. (23,29) High levels of TGF-β are also found in the pleural fluid. (18) The data obtained in the present study are in agreement with those presented in the literature, since levels of TGF-β were found to be significantly higher in the patients, with or without stimulus, before treatment, after three months of treatment and at the end of treatment.…”

Section: Discussionmentioning

confidence: 99%

Citocinas e proteínas de fase aguda do soro como marcadores de regressão da resposta inflamatória ao tratamento da tuberculose pulmonar

et al. 2008

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Objective: To evaluate the pattern of pro-inflammatory cytokines, anti-inflammatory cytokines and the acute phase response (APR) as markers of the response to treatment of pulmonary tuberculosis. Methods: Twenty-eight patients with pulmonary tuberculosis were evaluated at three time points: pretreatment (T0), treatment month 3 (T3) and treatment month 6 (T6). Levels of interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α), interleukine-10 (IL-10) and transforming growth factor-beta (TGF-β) were determined using ELISA in the supernatant of peripheral blood mononuclear cell and monocyte culture. Levels of total protein, albumin, globulins, C-reactive protein (CRP), alpha-1-acid glycoprotein (AAG) and erythrocyte sedimentation rate (ESR) were also determined. All of these parameters were also evaluated, only once, in a group of healthy controls. Results: In relation to controls, patients presented cytokine levels and APR that were higher at T0, lower at T3 and either lower (TNF-α, IL-10, TGF-β, AAG and ESR) or normal (IFN-γ and CRP) at T6. Conclusions: For individuals with negative smear sputum microscopy, CRP, AAG and ESR are potential markers of pulmonary tuberculosis and of the need for treatment; CRP (T0 > T3 > T6 = reference) can also be a marker of treatment response. In the patients, the Th0 profile (IFN-γ, IL-10, TNF-α and TGF-β), inducer of and protector against inflammation, predominated at T0, whereas the Th2 profile (IL-10, TNF-α and TGF-β), protecting against the harmful pro-inflammatory effect of the remaining TNF-α, predominated at T6. The behavior of IFN-γ (T0 > T3 > T6 = controls) suggests its use as a marker of treatment response.Keywords: Acute-phase proteins; Cytokines; Mycobacterium tuberculosis; Tuberculosis/therapy. ResumoObjetivo: Analisar o padrão de citocinas pró-e antiinflamatórias e da resposta de fase aguda (RFA) como marcadores de resposta ao tratamento da tuberculose pulmonar. Métodos: Determinação dos níveis de interferon-gama (IFN-γ), tumor necrosis factor-alpha (TNF-α, fator de necrose tumoral-alfa), interleucina-10 (IL-10) e transforming growth factor-beta (TGF-β, fator transformador de crescimento-beta), pelo método ELISA, em sobrenadante de cultura de células mononucleares do sangue periférico e monócitos, assim como dos níveis de proteínas totais, albumina, globulinas, alfa-1-glicoproteína ácida (AGA), proteína C reativa (PCR) e velocidade de hemossedimentação (VHS) em 28 doentes com tuberculose pulmonar, em três tempos: antes (T0), aos três meses (T3) e aos seis meses (T6) de tratamento, em relação aos controles saudáveis, em um único tempo. Resultados: Os pacientes apresentaram valores maiores de citocinas e RFA que os controles em T0, com diminuição em T3 e diminuição (TNF-α, IL-10, TGF-β, AGA e VHS) ou normalização (IFN-γ e PCR) em T6. Conclusões: PCR, AGA e VHS são possíveis marcadores para auxiliar no diagnóstico de tuberculose pulmonar e na indicação de tratamento de indivíduos com baciloscopia negativa; PCR (T0 > T3 > T6 = referência) pode também ser mar...

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“…TB is also accompanied by increased expression of Foxp3, characteristic of the ''constitutive'' CD25+ Foxp3+T reg (Guyot-Revol et al, 2006) (note that it has become usual to use the term T reg for this type of RegT, but we use ''RegT'' to refer collectively to all types of regulatory T cell). Moreover levels of TGF-b are raised in serum of TB patients and TGF-b is released by patients' cells in vitro suggesting the possibility that there might also be Th3 RegT (Fiorenza et al, 2005;Toossi and Ellner, 1998). A study using heat-killed Listeria monocytogenes as an immunomodulator in a mouse allergy model identified Th1-like RegT expressing TBet (Stock et al, 2004).…”

Section: Mode Of Action Of M Vaccaementioning

confidence: 99%

Mycobacteria and allergies

2007

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TNF-α, TGF-β and NO relationship in sera from tuberculosis (TB) patients of different severity

Cited by 48 publications

References 15 publications

Leukotriene A4 Hydrolase Genotype and HIV Infection Influence Intracerebral Inflammation and Survival From Tuberculous Meningitis

Leukotriene A4 Hydrolase Genotype and HIV Infection Influence Intracerebral Inflammation and Survival From Tuberculous Meningitis

Citocinas e proteínas de fase aguda do soro como marcadores de regressão da resposta inflamatória ao tratamento da tuberculose pulmonar

Mycobacteria and allergies

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