TNF-α promoter hypomethylation is frequent in oncopediatric patients who recovered from mucositis
José Maria Chagas VIANA FILHO,
Marina de CASTRO COÊLHO,
José Nunes de QUEIROZ NETO
et al.
Abstract:The aim of this study was to investigate the DNA methylation profile in genes encoding catalase (CAT) and superoxide dismutase (SOD3) enzymes, which are involved in oxidative stress mechanisms, and in genes encoding pro-inflammatory cytokines interleukin-6 (IL6) and tumor necrosis factor-alpha (TNF-α) in the oral mucosa of oncopediatric patients treated with methotrexate (MTX ® ). This was a cross-sectional observational study and the population comprised healthy dental patients (n = 21) and those with hematol… Show more
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