TNF-α Preconditioning Promotes a Proangiogenic Phenotype in hiPSC-Derived Vascular Smooth Muscle Cells

Sasson, Daniel C; Islam, Sara; Duan, Kaiti; Dash, Biraja C.; Hsia, Henry C.

doi:10.1007/s12195-023-00764-0

Cited by 1 publication

(1 citation statement)

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“…In fact, cells derived from iPSCs may contribute to extracellular matrix (ECM) deposition, angiogenesis, cell proliferation, and immunoregulation [ 14 ]. Sasson et al [ 54 ] have investigated TNF-α preconditioned human iPSC in terms of cellular viability and secretome when integrated into a 3D collagen scaffold. Their results showed improved cell viability as well as a significant increase in vascular endothelial growth factor (VEGF) expression in the preconditioned human iPSCs meaning that augmented cellular viability in combination with secretion of paracrine factors could lead to improved wound healing due to migration (Fig.…”

Section: Cellular Therapies For Wound Healingmentioning

confidence: 99%

Cellular therapeutics and immunotherapies in wound healing – on the pulse of time?

Huelsboemer,

Knoedler,

Kochen

et al. 2024

Military Med Res

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Chronic, non-healing wounds represent a significant challenge for healthcare systems worldwide, often requiring significant human and financial resources. Chronic wounds arise from the complex interplay of underlying comorbidities, such as diabetes or vascular diseases, lifestyle factors, and genetic risk profiles which may predispose extremities to local ischemia. Injuries are further exacerbated by bacterial colonization and the formation of biofilms. Infection, consequently, perpetuates a chronic inflammatory microenvironment, preventing the progression and completion of normal wound healing. The current standard of care (SOC) for chronic wounds involves surgical debridement along with localized wound irrigation, which requires inpatient care under general anesthesia. This could be followed by, if necessary, defect coverage via a reconstructive ladder utilizing wound debridement along with skin graft, local, or free flap techniques once the wound conditions are stabilized and adequate blood supply is restored. To promote physiological wound healing, a variety of approaches have been subjected to translational research. Beyond conventional wound healing drugs and devices that currently supplement treatments, cellular and immunotherapies have emerged as promising therapeutics that can behave as tailored therapies with cell- or molecule-specific wound healing properties. However, in contrast to the clinical omnipresence of chronic wound healing disorders, there remains a shortage of studies condensing the current body of evidence on cellular therapies and immunotherapies for chronic wounds. This review provides a comprehensive exploration of current therapies, experimental approaches, and translational studies, offering insights into their efficacy and limitations. Ultimately, we hope this line of research may serve as an evidence-based foundation to guide further experimental and translational approaches and optimize patient care long-term.

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Section: Cellular Therapies For Wound Healingmentioning

confidence: 99%