TNF-α, myocardial perfusion and function in patients with ST-segment elevation myocardial infarction and primary percutaneous coronary intervention

Kehmeier, Eva; Lepper, W.; Kropp, Martina; Heiß, Christian; Hendgen‐Cotta, Ulrike B.; Balzer, Jan C.; Neizel, Mirja; Meyer, Christian; Merx, Marc W.; Verde, Pablo Emilio; Ohmann, Christian; Heusch, Gerd; Kelm, Malte; Rassaf, Tienush

doi:10.1007/s00392-012-0465-x

Cited by 25 publications

(14 citation statements)

References 107 publications

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“…Prior clinical and experimental studies have shown that resistin may promote the inflammatory process via upregulating the expression of proinflammatory cytokines, including TNF-α, interleukin-6, and monocyte chemoattractant protein-1 [5,22]. TNF-α and MIF levels upon admission all participate in the process of IRI [19,23,24], and our present research indicated for the first time that resistin at admission correlated positively with them in STEMI patients. In addition to inflammation, previous studies revealed that oxidative stress also contributed to IRI via reactive oxygen species (ROS) [20,21,25].…”

Section: Discussionsupporting

confidence: 65%

Significant association between serum resistin and hypersensitive troponin I levels in patients with a first ST-segment elevation myocardial infarction

Zhu

Liu

et al. 2019

Preprint

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Background Resistin, a proinflammatory adipocytokine secreted predominately by macrophages in humans, plays an important role in the pathogenesis and development of atherosclerosis. The present research mainly investigated the association between serum resistin level and peak hypersensitive cardiac troponin I (hs-cTnI) in patients with ST-segment elevation myocardial infarction (STEMI).Methods We consecutively enrolled 92 patients with a first STEMI in this cross-sectional and observational study. Resistin concentrations upon admission and 24 h and 72 h after primary percutaneous coronary intervention (PCI) were all measured. The change in resistin (δ Resistin) was defined as (serum resistin concentration at admission)-(serum resistin concentration 24 h after intervention).Results Serum resistin concentration decreased rapidly after primary PCI. Resistin at admission correlated positively with tumour necrosis factor-α (r = 0.522, p<0.001) and macrophage migration inhibitory factor (r = 0.471, p<0.001). Additionally, resistin at admission correlated negatively with the reactive oxygen species scavengers superoxide dismutase (r = -0.261, p = 0.012) and glutathione peroxidase (r = -0.235, p = 0.024). Most importantly, serum resistin concentrations upon admission (r = 0.381, p<0.001) and 24 h (r = 0.372, p<0.001) and 72 h (r = 0.347, p = 0.001) after primary PCI all correlated with peak hs-cTnI, while δ Resistin was not associated with peak hs-cTnI. After multiple linear regression analysis, serum resistin (beta = 13.593, 95% CI 5.951 to 21.235, p < 0.001) at admission and 24 h (beta = 13.972, 95% CI 5.662 to 22.282, p = 0.001) and 72 h (beta = 14.455, 95% CI 5.178 to 23.733, p = 0.003) after intervention remained associated with peak hs-cTnI.Conclusions In our present research, serum resistin concentrations at different time points all correlated positively with peak hs-cTnI, which may suggest that serum resistin concentrations during the acute phase of STEMI are useful for forecasting myocardial infarction size and prognosis in patients after primary PCI. Additionally, our research also indicated that resistin may regulate myocardial IRI partly by promoting the inflammatory process and oxidative stress.

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Section: Discussionsupporting

confidence: 65%

Significant association between serum resistin and hypersensitive troponin I levels in patients with a first ST-segment elevation myocardial infarction

Zhu

Liu

et al. 2019

Preprint

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“…Higher levels of neopterin are associated with the development of left ventricular dysfunction [ 31 ] and left ventricular remodelling [ 32 ] in patients with STEMI. TNF- α is rapidly released from resident mast cells and macrophages during MI [ 33 ] and its level is correlated closely with the extent of MI [ 34 ]. Our results showed a significant association between tertiles of PTX3 levels and those of neopterin and TNF- α and also significant but weak correlation between PTX3 at 24 h and level of neopterin and TNF- α in whole group of patients.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Pentraxin-3 Level in Patients with STEMI and Its Relationship with Heart Failure and Markers of Oxidative Stress

et al. 2015

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Objective. Pentraxin-3 (PTX3) appears to have a cardioprotective effect through a positive influence against postreperfusion damage. This study assesses the prognostic value of PTX3 level and its relationship with clinical parameters and markers of oxidative stress and nitric oxide metabolism in patients with ST-elevation myocardial infarction (STEMI). Methods. Plasma/serum levels of several biomarkers of inflammation and oxidative stress and nitrite/nitrate were assessed upon admission and 24 h after STEMI onset in patients treated by primary percutaneous coronary intervention. Results. ROC analysis showed that plasma PTX3 at 24 h was a strong predictor of 30-day and 1-year mortality and independent predictor of combined end-point of left ventricle dysfunction or mortality in 1 year. The inflammatory response expressed by PTX3 had a significant relationship with age, heart failure, infarct size, impaired flow in the infarct-related artery, and renal function and positively correlated with neopterin, TNF-α, 8-hydroxy-2′-deoxyguanosine, and nitrite/nitrate. Conclusions. Plasma PTX3 at 24 h after STEMI onset is a strong predictor of 30-day and 1-year mortality. PTX3 as a single biomarker is comparable with currently used scoring systems (TIMI or GRACE) or B-type natriuretic peptide. PTX3 is also an independent predictor of combined end-point of left ventricle dysfunction or mortality in 1 year.

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“…Levels of TNF-α and its receptors are elevated also in patients with acute myocardial infarction and can predict infarct size, LV dysfunction and prognosis [22, 34, 35]. A study by Kehmeier et al showed that TNF-α levels measured in STEMI patients after PCI can predict infarct size [34].…”

Section: Main Textmentioning

confidence: 99%

“…A study by Kehmeier et al showed that TNF-α levels measured in STEMI patients after PCI can predict infarct size [34]. Nilsson et al measured soluble TNF-receptors in STEMI patients prior to and 24 h after PCI and showed that concentrations of TNFR1 and TNFR2 are associated with infarct size and LV dysfunction [22].…”

Section: Main Textmentioning

confidence: 99%

Apoptosis in ischemic heart disease

2017

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Apoptosis plays an important role in the myocardial loss after acute myocardial infarction and participates in the process of subsequent left ventricular remodeling and development of symptomatic heart failure. Finding a sensitive apoptotic marker that would help in prognostic stratification of patients after acute myocardial infarction and offer new therapeutic strategies is thus of a great importance. Several studies suggest that tumor necrosis factor-related apoptosis inducing ligand (TRAIL) represents a very promising marker of prognosis in patients with acute myocardial infarction. This review article provides an overview of current knowledge on the role of apoptosis in ischemic heart disease and highlights potentially beneficial apoptotic markers in clinical practice.

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TNF-α, myocardial perfusion and function in patients with ST-segment elevation myocardial infarction and primary percutaneous coronary intervention

Abstract: Our data reflect the clinical significance of early TNF-α elevation in patients with STEMI and primary PCI (Controlled Clinical Trials number, NCT00529607).

Cited by 25 publications

References 107 publications

Significant association between serum resistin and hypersensitive troponin I levels in patients with a first ST-segment elevation myocardial infarction

Significant association between serum resistin and hypersensitive troponin I levels in patients with a first ST-segment elevation myocardial infarction

Prognostic Value of Pentraxin-3 Level in Patients with STEMI and Its Relationship with Heart Failure and Markers of Oxidative Stress

Apoptosis in ischemic heart disease

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