TNF-α inhibitory diterpenoids from the Chinese mangrove plant Excoecaria agallocha L.

Li, Yongxin; Li, Jun; Shao, Yu; Proksch, Peter; Gu, Jun; Lin, Wenhan

doi:10.1016/j.phytochem.2010.08.011

Cited by 41 publications

(35 citation statements)

References 32 publications

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“…The 1 H and 13 C NMR data (Table 2), suggested the structure of a tetracyclic diterpene with an ent-atisane backbone. According to the analysis of the spectral data obtained, and comparison with the literature data, it was possible to suggest that compound ICB8 was indeed the ent-3,4-secoatisa-4(18),16-dien-3-oic acid, previously isolated from Excoecaria agallocha L. 32 ( Figure 1), isolated for the first time from C. blanchetianus.…”

Section: Resultsmentioning

confidence: 71%

Antimicrobial Activity of 3,4-seco-Diterpenes Isolated from Croton blanchetianus against Streptococcus mutans and Streptococcus parasanguinis

Firmino¹,

Alexandre²,

Vasconcelos³

et al. 2017

J. Braz. Chem. Soc.

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In this study, acid and neutral fractions and three diterpenes were isolated from the hexane extracts from roots of three individual specimens of Croton blanchetianus Baill., collected from the same geographical site. Moreover, the antimicrobial activity of the extracts, fractions and diterpenes isolated was evaluated against Streptococcus mutans and Streptococcus parasanguinis, bacteria related with dental caries. The structures of the diterpenes were elucidated mainly by 1D and 2D nuclear magnetic resonance (NMR) spectroscopy, and high-resolution mass spectrometry, such as methyl 12-hydroxy-3,4-seco-cleistanta-8,11,13,15,4(18)-pentaene-3-oate; ent-3,4-secoatisa-4(18),16-dien-3-oic acid and a novel diterpene 3,4-seco-beieren-3-oic acid. Regarding to the antimicrobial activity, in general, all extracts, the neutral and acid fractions of the hexane extracts roots of all three specimens, showed antimicrobial activity in concentrations ranging from 500 to 7.8 µg mL -1 . In addition, the three diterpenes isolated showed bactericidal and bacteriostatic activity against S. mutans and S. parasanguinis, suggesting them as alternative agents with the potential to prevent oral diseases.

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Section: Resultsmentioning

confidence: 71%

Antimicrobial Activity of 3,4-seco-Diterpenes Isolated from Croton blanchetianus against Streptococcus mutans and Streptococcus parasanguinis

Firmino¹,

Alexandre²,

Vasconcelos³

et al. 2017

J. Braz. Chem. Soc.

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“…Diterpenoids from the Chinese mangrove plant Excoecaria agallocha L. (Euphorbiaceae) were found to inhibit TNF-␣, IL-6 and other pro-inflammatory markers. The mechanism of this anti-inflammatory activity of these diterpenoids was mediated by the suppression of NF-B and/or activator protein-1 (AP-1) signalling pathways (Li et al, 2010). AP-1 is one of the important transcription factors during the inflammatory processes.…”

Section: Discussionmentioning

confidence: 99%

The cardioprotective effects of marrubiin, a diterpenoid found in Leonotis leonurus extracts

Mnonopi

Levendal

Davies‐Coleman

et al. 2011

Journal of Ethnopharmacology

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“…[822232425262728293031323334353637383940414243444546474849505152535455] The details of their names are given in Table 5. The chemical structures of some isolated compounds are given in Figure 2.…”

Section: Introductionmentioning

confidence: 99%

“…Most of the kaurane diterpenes are ent-kaurane derivatives. [233439404142] Fifteen Beyerane-type diterpenes 68–82 were also isolated from different parts of the plant. [242534363942]…”

Section: Introductionmentioning

confidence: 99%

“…Fourteen artisane-type diterpenes 83–96 were isolated from different parts of E. agallocha ,[24343640414344] out of which compounds 83 and 84 are isolated from woods,[2440] compounds 85–88 were isolated from bark,[43] compound 89 was isolated from the twigs and stems,[41] and compound 96 was isolated from stems only[34] and stems and leaves yielded five artisane diterpene 90–95. [343644]…”

Section: Introductionmentioning

confidence: 99%

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A complete profile on blind-your-eye mangrove Excoecaria agallocha L. (Euphorbiaceae): Ethnobotany, phytochemistry, and pharmacological aspects

Mondal¹,

Ghosh²,

Ramakrishna³

2016

Phcog Rev

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Traditional system of medicine consists of large number of plants with various medicinal and pharmacological importances. This article provides a comprehensive review of the complete profile of an important mangrove plant Excoecaria agallocha L. (Euphorbiaceae) and elaborately describing the ethnobotany, phytochemistry, and pharmacological properties. It is used traditionally in the treatment of various diseases such as epilepsy, ulcers, leprosy, rheumatism, and paralysis. The latex obtained from the bark is poisonous in nature and may cause temporary blindness, thus it is also known as the blind-your-eye mangrove plant. Many phytoconstituents were isolated from the plant, which were mainly diterpenoids, triterpenoids, flavonoids, sterols, and few other compounds. The plant also showed many pharmacological activities such as antioxidant, antimicrobial, anti-inflammatory, analgesic, antiulcer, anticancer, antireverse transcriptase, antihistamine-release, antifilarial, DNA damage protective, antidiabetic, and antitumor protecting activities. Hence, this review could help guide researchers anticipating to undertake further investigations in these directions.

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TNF-α inhibitory diterpenoids from the Chinese mangrove plant Excoecaria agallocha L.

Cited by 41 publications

References 32 publications

Antimicrobial Activity of 3,4-seco-Diterpenes Isolated from Croton blanchetianus against Streptococcus mutans and Streptococcus parasanguinis

Antimicrobial Activity of 3,4-seco-Diterpenes Isolated from Croton blanchetianus against Streptococcus mutans and Streptococcus parasanguinis

The cardioprotective effects of marrubiin, a diterpenoid found in Leonotis leonurus extracts

A complete profile on blind-your-eye mangrove Excoecaria agallocha L. (Euphorbiaceae): Ethnobotany, phytochemistry, and pharmacological aspects

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