TNF-α inhibition, antioxidant effects and chemical analysis of extracts and fraction from Brazilian guaraná seed powder

Machado, Kamilla Nunes; Barbosa, Antony de Paula; Freitas, Aline Alves de; Alvarenga, Luana Farah; Pádua, Rodrigo Maia de; Faraco, André Augusto Gomes; Braga, Fernão Castro; Vianna-Soares, Cristina Duarte; Castilho, Rachel Oliveira

doi:10.1016/j.foodchem.2021.129563

Cited by 12 publications

(9 citation statements)

References 23 publications

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“…(Sapindaceae), have been used for centuries by Amazonian indigenous tribes as a stimulant in festivals and hunting, aphrodisiac, and medicinal uses (Mendes et al, 2019 ). It is consumed as a powder obtained from toasted seeds, or it can be taken simply by dissolving the powder in water, alone, or in combination with other herbal medicine (Machado et al, 2021 ). Guaraná is known for its high amount of caffeine (3.5%–6%) (Pagliarussi, Freitas, & Bastos, 2002 ).…”

Section: Resultsmentioning

confidence: 99%

“…Evidence has shown that guaraná presents strong antioxidant and radical‐ scavenging properties (Maldaner et al, 2020 ; Roggia et al, 2020 ; Santana & Macedo, 2018 ; Yonekura et al, 2016 ), protective cellular and anti‐inflammatory properties (Machado et al, 2021 ), neuroprotective effect (Veloso et al, 2018 ), and anti‐aging proprieties (Arantes et al, 2018 ) An epidemiological study reported guaraná habitual consumption by older adult riverine with a lower prevalence of hypertension, obesity, and metabolic syndrome (da Costa Krewer et al, 2011 ). Yonekura et al ( 2016 ) had shown that small daily doses of guaraná (3 g) can improve oxidative stress markers in healthy subjects (Yonekura et al, 2016 ).…”

Section: Resultsmentioning

confidence: 99%

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Amazonian fruits with potential effects on COVID‐19 by inflammaging modulation: A narrative review

Manica-Cattani¹,

Hoefel²,

Azzolin³

et al. 2022

Journal of Food Biochemistry

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The COVID‐19 pandemic had a great impact on the mortality of older adults and, chronic non‐ transmissible diseases (CNTDs) patients, likely previous inflammaging condition that is common in these subjects. It is possible that functional foods could attenuate viral infection conditions such as SARS‐CoV‐2 (severe acute respiratory syndrome coronavirus 2), the causal agent of COVID‐19 pandemic. Previous evidence suggested that some fruits consumed by Amazonian Diet from Pre‐Colombian times could present relevant proprieties to decrease of COVID‐19 complications such as oxidative‐cytokine storm. In this narrative review we identified five potential Amazonian fruits: açai berry (Euterpe oleracea), camu‐camu (Myrciaria dubia), cocoa (Theobroma cacao), Brazil nuts (Bertholletia excelsa), and guaraná (Paullinia cupana). Data showed that these Amazonian fruits present antioxidant, anti‐inflammatory and other immunomodulatory activities that could attenuate the impact of inflammaging states that potentially decrease the evolution of COVID‐19 complications. The evidence compiled here supports the complementary experimental and clinical studies exploring these fruits as nutritional supplement during COVID‐19 infection. Practical applications These fruits, in their natural form, are often limited to their region, or exported to other places in the form of frozen pulp or powder. But there are already some companies producing food supplements in the form of capsules, in the form of oils and even functional foods enriched with these fruits. This practice is common in Brazil and tends to expand to the international market.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Amazonian fruits with potential effects on COVID‐19 by inflammaging modulation: A narrative review

Manica-Cattani¹,

Hoefel²,

Azzolin³

et al. 2022

Journal of Food Biochemistry

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“…Finally, a recent study using a methylxanthine‐free and tannin‐rich guarana extract reported that the administration of 90 μg/ml of extract to THP‐1 cells activated by lipopolysaccharides inhibited TNF‐α production by almost 84% while presenting no toxicity to these cells (Machado et al., 2021). Nonetheless, further studies on humans are necessary to elucidate and confirm the anti‐inflammatory effects of guarana and its applicability in human health.…”

Section: Effects On Human Healthmentioning

confidence: 99%

“…More recently, Machado et al. (2021) demonstrated that guarana extracts with and without methylxanthines displayed antioxidant activity measured by their ability to scavenge 2,2‐diphenyl‐1‐picrylhydrazyl radicals (i.e., DPPH assay). In particular, the extract free of methylxanthines but rich in tannins had a half maximal inhibitory concentration of 5.88 μg/ml, demonstrating the antioxidant potential of guarana‐derived tannins.…”

Section: Effects On Human Healthmentioning

confidence: 99%

Effects of the consumption of guarana on human health: A narrative review

Torres

Pinaffi-Langley

Figueira

et al. 2021

Comp Rev Food Sci Food Safe

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Guarana (Paullinia cupana) is a plant from the Amazon region with cultural importance. Despite its early ancestral use by indigenous tribes, the first reports regarding the benefits of guarana consumption for human health were published in the 19th century. Since then, the use of guarana seed in powder and extract forms has been studied for its diverse effects on human health, such as stimulating, anti-inflammatory, antioxidant, anticancer, hypocholesterolemic, and antiobesity effects. These effects are attributed to the high content of bioactive compounds found in guarana seeds, especially methylxanthines and flavonoids. In fact, the Brazilian Food Supplement Law has officially acknowledged guarana as a source of bioactive compounds. The number and diversity of studies focused on guarana and human health are increasing; thus, organizing and describing the available evidence on guarana and its applications is necessary to provide a framework for future studies. In this narrative review, we have organized the available information regarding guarana and its potential effects on human health. Guarana produces unique fruits with great potential for human health applications. However, the available evidence lacks human studies and mechanistic investigations. Future studies should be designed considering its applicability to human health, including intake levels and toxicity studies.

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“…Guaraná, a natural product obtained from the seeds of P. cupana Kunth, is native to the Amazon region and widely used in Brazil due its stimulant properties [1]. Several studies have demonstrated its anti-inflammatory, anti-obesity and antiproliferative activities both in vitro and in vivo [2][3][4]. Due to these excellent results, this herb has gained popularity and has been used worldwide.…”

Section: Introductionmentioning

confidence: 99%

Alteration of the Pharmacokinetics of Theophylline by Paullinia cupana Kunth in Rats

Batista

Lima

Corrêa

et al. 2021

EJMP

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Aims: Paullinia cupana Kunth has been popularly used to prepare different beverages by the Amazonian inhabitants for a long time ago mainly due to its stimulant properties. Although the utilization of this herbal drug has been increasing lately, little is known regarding the possibility of drug interactions. Therefore, this research tried to investigate the effects of the aqueous extract of P. cupana on the pharmacokinetics of theophylline (TPH), a CYP1A marker in rats. Methodology: The extract was prepared according to the popular recipe and subjects received different once daily doses of extract (vehicle, 82.1 mg/Kg and 821 mg/Kg) by oral gavage during two weeks. Non-compartimental analysis was carried out to obtain the pharmacokinetic parameters. Results: Animals treated with P. cupana (AUC: 1,197.2 ± 284.4 and 346.6 ± 37.0 µg.h/mL for 82.1 and 821 mg/Kg, respectively) had lower exposition to TPH than controls (3,539.48 ± 278.4 µg.h/mL). On the other hand, drug clearance was higher in treated subjects (2.44 ± 0.4 and 7.27 ± 0.7 L/h/kg for 82.1 and 821 mg/Kg, respectively) than controls (0.71 ± 0.0 L/h/kg). Conclusion: Therefore, the multiple oral administration of an aqueous extract of P. cupana caused a significant effect on the pharmacokinetics of TPH in rats.

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TNF-α inhibition, antioxidant effects and chemical analysis of extracts and fraction from Brazilian guaraná seed powder

Cited by 12 publications

References 23 publications

Amazonian fruits with potential effects on COVID‐19 by inflammaging modulation: A narrative review

Amazonian fruits with potential effects on COVID‐19 by inflammaging modulation: A narrative review

Effects of the consumption of guarana on human health: A narrative review

Alteration of the Pharmacokinetics of Theophylline by Paullinia cupana Kunth in Rats

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