TNF-α-induced lncRNA LOC105374902 promotes the malignant behavior of cervical cancer cells by acting as a sponge of miR-1285-3p

Feng, Yujie; Ma, Jingfei; Fan, Hongxia; Liu, Min; Zhu, Yunjuan; Li, Yongmei; Tang, Hua

doi:10.1016/j.bbrc.2019.03.079

Cited by 29 publications

(22 citation statements)

References 29 publications

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“…Furthermore, up‐regulated E2F4 led to the suppression of cell proliferation and tumorigenesis of Burkitt lymphoma 15 . LncRNAs have been demonstrated to mediate gene expression at transcriptional, post‐transcriptional or epigenetic levels 32 . The silencing of E2F4 diminished proliferation of human intestinal epithelial cells and CRC cells, 33 which supports the regulatory role of E2F4 in cell progression in cancers.…”

Section: Discussionmentioning

confidence: 80%

LncRNA HAND2‐AS1 represses cervical cancer progression by interaction with transcription factor E2F4 at the promoter of C16orf74

Gong

Fan

Deng³

et al. 2020

J Cellular Molecular Medi

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Cervical cancer is one of the major malignancies, the pathophysiology and progression of which remain to be scarcely understood. Long non‐coding RNAs (lncRNAs) have been previously implicated in the progression of cervical cancer. Here, the purpose of this study was to identify whether lncRNA heart‐ and neural crest derivative‐expressed 2‐antisense RNA 1 (HAND2‐AS1) affect the development of cervical cancer through regulation of chromosome 16 open reading frame 74 (C16orf74) by mediating a transcription factor E2F4. RT‐qPCR was performed to determine the expression of HAND2‐AS1 in cervical cancer cells. Then, cervical cancer cells were treated with HAND2‐AS1 or si‐E2F4 RNA, or C16orf74, after which the proliferation, colony formation, migration and invasion were detected. Moreover, the binding between HAND2‐AS1 and E2F4 or between E2F4 and C16orf74 was explored. Finally, the tumorigenesis of cervical cancer cells was measured in nude mice with altered HAND2‐AS1/E2F4/C16orf74 expression. HAND2‐AS1 exhibited poor expression in cervical cancer, and HAND2‐AS1 overexpression suppressed the proliferation, colony formation, migration and invasion of cervical cancer cells. In addition, HAND2‐AS1 was found to recruit transcription factor E2F4 to C16orf74 promoter region and down‐regulate C16orf74 expression. Lastly, HAND2‐AS1/E2F4/C16orf74 modulated the tumorigenesis of cervical cancer in nude mice. In conclusion, this study provided evidence on the inhibitory effect of HAND2‐AS1 on the development of cervical cancer through the suppression of C16orf74 expression by recruiting transcription factor E2F4. This study highlights the potential of lncRNA HAND2‐AS1 as a target in the treatment of cervical cancer.

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Section: Discussionmentioning

confidence: 80%

LncRNA HAND2‐AS1 represses cervical cancer progression by interaction with transcription factor E2F4 at the promoter of C16orf74

Gong

Fan

Deng³

et al. 2020

J Cellular Molecular Medi

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“…31 Besides, miR-1285-3p was reported to suppress the malignant behaviors in cervical cancer. 32 Moreover, miR-1285-3p targets YAP1 to repress osteosarcoma growth and serves as a prognostic marker. 33 In our study, we showed that miR-1285-3p inhibition could abrogate the effects of LEF1-AS1 knockdown on ovarian cancer progression.…”

Section: Discussionmentioning

confidence: 99%

<p>LncRNA LEF1-AS1 Promotes Ovarian Cancer Development Through Interacting with miR-1285-3p</p>

Zhang

Ruan

2020

CMAR

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Background: Growing evidence indicates that long noncoding RNA (lncRNA) is a group of important regulator in cancer development. However, the correlation between lncRNA and ovarian cancer remains elusive. Here, we aimed to investigate the roles of LEF1-AS1 in ovarian cancer progression. Methods: LEF1-AS1 expression was analyzed by quantitative real-time polymerase chain reaction (qRT-PCR). Survival rate was analyzed by Kaplan-Meier method. Cell Counting Kit-8 (CCK8) and colony formation assays were used for proliferation analysis. Transwell assay was utilized for analyses of migration and invasion. Luciferase reporter assay was performed to test the interaction between LEF1-AS1 and miR-1285-3p. Results: We showed that LEF1-AS1 expression was upregulated in ovarian cancer tissues compared with normal tissues. Besides, LEF1-AS1 level was positively correlated with lymph node metastasis and advanced stage. Enhanced expression of LEF1-AS1 may predict a poor prognosis. Moreover, LEF1-AS1 knockdown suppressed ovarian cancer cell proliferation, migration and invasion. Mechanistically, LEF1-AS1 exerted its oncogenic functions through interacting with miR-1285-3p to inhibit miRNA activity. Rescue assay validated that miR-1285-3p inhibitors abrogated LEF1-AS1-silencer-caused suppression of ovarian cancer progression. Conclusion: Our study revealed that LEF1-AS1 acts as a vital regulation in ovarian cancer progression.

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“…LncRNAs are known to exert their function on CC via multiple steps (24). For example, the lncRNA LOC105374902 promotes the malignancy of CC cells by acting as a sponge of miR-1285-3p, a process enhanced by TNF-α (25). Furthermore, the lncRNA SBF2-AS1 promotes the progression of CC by regulating the miR-361-5p/FOXM1 axis (26), while the lncRNA BDNF-Anti-Sense is downregulated in CC and possesses anti-tumor functions by negatively associating with brain-derived neurotrophic factor (27).…”

Section: Discussionmentioning

confidence: 99%

Long non‑coding RNA RP11‑480I12.5 promotes cervical carcinoma progression by regulating the Wnt/β‑catenin signaling pathway

Zhang¹,

Sona³

2019

Oncol Lett

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T he long non-coding R NA (lncR NA), RP11-480I12.5 is one of the most dysregulated lncRNAs, which is believed to contribute to the progression of cervical carcinoma (CC); however, the exact function of RP11-480I12.5 in human CC remains unknown. The present study aimed to investigate the function and underlying molecular mechanism of RP11-480I12.5 in CC. First, reverse transcription-quantitative PCR was implemented in order to detect differences in the expression of RP11-480I12.5 between normal and CC tissues. The present study used in vitro analysis to establish RP11-480I12.5 stable knockdown and overexpressing cell lines, in order to investigate the function and potential molecular mechanism of RP11-480I12.5 in the progression of CC. RP11-480I12.5 was upregulated in CC tissue compared with normal tissue. Furthermore, RP11-480I12.5 was associated with clinical stage, tumor size and lymph node metastasis. RP11-480I12.5 promoted the proliferation, migration and invasion of CC cell lines. Subsequently, the present study investigated the association between RP11-480I12.5 and the epithelial-to-mesenchymal transition (EMT) and Wnt/β-catenin pathways. RP11-480I12.5 promoted EMT through the Wnt/β-catenin pathway. Overall, the results of the present study demonstrate that RP11-480I12.5 promotes cercical cancer cell migration, invasion and EMT through the Wnt/β-catenin pathway.

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TNF-α-induced lncRNA LOC105374902 promotes the malignant behavior of cervical cancer cells by acting as a sponge of miR-1285-3p

Cited by 29 publications

References 29 publications

LncRNA HAND2‐AS1 represses cervical cancer progression by interaction with transcription factor E2F4 at the promoter of C16orf74

LncRNA HAND2‐AS1 represses cervical cancer progression by interaction with transcription factor E2F4 at the promoter of C16orf74

<p>LncRNA LEF1-AS1 Promotes Ovarian Cancer Development Through Interacting with miR-1285-3p</p>

Long non‑coding RNA RP11‑480I12.5 promotes cervical carcinoma progression by regulating the Wnt/β‑catenin signaling pathway

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