TNF-α-induced apoptosis in human naïve and memory CD8+ T cells in aged humans

Gupta, Sudhir; Gollapudi, Sastry

doi:10.1016/j.exger.2005.10.001

Cited by 36 publications

(28 citation statements)

References 50 publications

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“…The decline of E 2 level and physical aging after menopause may affect the apoptotic ability of T lymphocytes. Many studies had reported the increased apoptotic susceptibility of aging T cells (13)(14)(15). In our study, the T lymphocyte apoptotic rate of post-menopausal women was significantly higher than that of pre-menopausal women, in consistent with the previous results.…”

Section: Discussionsupporting

confidence: 93%

Effects of Transdermal Estrogen Therapy on Expressions of Estrogen Receptors and T-lymphocyte Apoptosis in Surgically Menopausal Women

et al. 2009

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Studies have demonstrated estrogen replacement therapy can improve the life quality of surgically menopausal women. However, the mechanisms in this process remain poorly defined. Here we show the effect of transdermal estrogen therapy on expressions of estrogen receptors and T-lymphocyte apoptosis in surgically postmenopausal women. Fifteen surgically menopausal women, 15 naturally menopausal women and 15 young women were chosen in our studies. Peripheral vein blood was collected and serum E 2 and FSH levels were assessed using ACCESS. T-lymphocyte apoptosis and the expressions of Fas, FasL and ER subtypes  and  were determined. The serum E 2 levels of surgically menopausal woman were significantly higher, and the "Improved Kupperman Index" and the scores of "Menopause Specific Quality of Life Questionnaire" in surgically menopausal women were significantly low after ERT. The rates of T-lymphocyte apoptosis and FasL expression in surgically menopausal women were decreased after ERT, but the difference was not significant. The expressions of ERα and ERβ in two menopausal groups were significantly lower than those of the young group. They were both significantly up-regulated after 3 months of ERT. Transdermal ERT could significantly upregulate the serum E 2 level, could improve menopausal symptoms and life quality of surgically menopausal women and upregulate ERα and ERβ expressions on T lymphocytes, especially ERβ. Thus, the low dose of transdermal ERT may have a protective effect on menopausal women's immune function and aging. Cellular & Molecular Immunology. 2009;6(4):277-283.

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Section: Discussionsupporting

confidence: 93%

Effects of Transdermal Estrogen Therapy on Expressions of Estrogen Receptors and T-lymphocyte Apoptosis in Surgically Menopausal Women

et al. 2009

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“…Both TNF receptors (p55 and p75) bind intracellular adaptor proteins that link receptor stimulation to the activation of many signaling processes and cellular responses including apoptosis (18,20,26). Unlike p55, p75 lacks a cytoplasmic death domain.…”

Section: Discussionmentioning

confidence: 99%

T cell killing by tolerogenic dendritic cells protects mice from allergy

Luckey¹,

Maurer²,

Schmidt³

et al. 2011

J. Clin. Invest.

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It is well established that allergy development can be prevented by repeated low-dose exposure to contact allergens. Exactly which immune mechanisms are responsible for this so-called low zone tolerance (LZT) is not clear, although CD8 + suppressor T cells are known to have a role. Here, we show that TNF released by tolerogenic CD11 + CD8 + DCs located in skin-draining lymph nodes is required and sufficient for development of tolerance to contact allergens in mice. DC-derived TNF protected mice from contact allergy by inducing apoptosis in allergen-specific effector CD8 + T cells via TNF receptor 2 but did not contribute to the generation and function of the regulatory T cells associated with LZT. The TNF-mediated killing mechanism was induced in an allergen-specific manner. Activation of tolerogenic DCs by LZT CD8 + suppressor T cells and enhanced TNF receptor 2 expression on contact allergen-specific CD8 + effector T cells were required for LZT. Our findings may explain how tolerance protects from allergic diseases, which could allow for the development of new strategies for allergy prevention.

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“…inf, infundibulum; ut, uterus; uvj, uterovaginal junction; vag, vagina; M, DNA marker of 100 bp ladder. response and immunity, few subsets of the TNF superfamily, including TNF, are also known to exhibit potent cytotoxic activity by inducing apoptosis of varieties of susceptible cell lines (Nagata 1997, Gupta & Gollapudi 2006, Chen et al 2007. Induction of germ cell death during spermatogenesis by TNF-related apoptosis-inducing ligand was also suggested in the adult human testis (Grataroli et al 2004).…”

Section: Sperm Survivability and Cytokines In Hen Oviductmentioning

confidence: 99%

Changes in the expression of interleukin-1β and lipopolysaccharide-induced TNF factor in the oviduct of laying hens in response to artificial insemination

Das¹,

Isobe²,

Yoshimura³

2009

Reproduction

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The aim of this study was to determine the physiological significance of interleukin-1b (IL1B) and lipopolysaccharide-induced TNF factor (LITAF) in the fate of sperm in the oviduct of laying hens after artificial insemination (AI ). Laying hens were inseminated with fresh semen, PBS or seminal plasma and tissues from different oviductal segments were collected to observe the general histology, changes in the mRNA expression of IL1B and LITAF and the localization of positive cells expressing immunoreactive IL1B (irIL1B). Semi-quantitative RT-PCR was used to observe the changes in mRNA expression of these molecules in the infundibulum, uterus, utero-vaginal junction (UVJ), and vagina after insemination. Intact sperm in the lumen and between the primary or secondary folds of the vagina were found until 6 h after insemination but were degraded at 12 h. The mRNA expression of IL1B and LITAF was significantly increased in the vagina until 6 h after AI but remained unchanged in the other oviductal segments. In the tissue of the vagina and UVJ, irIL1B was localized in the mucosal stroma. The number of irIL1B-positive cells was increased in the vagina but almost unchanged in UVJ after insemination with semen. Significant changes were not observed in the mRNA expression and irIL1B-positive cells in the vagina after PBS or seminal plasma insemination. The increase of IL1B and LITAF in the vagina may lead to sperm degradation and elimination by cilia of surface epithelium, whereas their lower levels in UVJ may permit sperm to survive in sperm storage tubules.

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TNF-α-induced apoptosis in human naïve and memory CD8+ T cells in aged humans

Cited by 36 publications

References 50 publications

Effects of Transdermal Estrogen Therapy on Expressions of Estrogen Receptors and T-lymphocyte Apoptosis in Surgically Menopausal Women

Effects of Transdermal Estrogen Therapy on Expressions of Estrogen Receptors and T-lymphocyte Apoptosis in Surgically Menopausal Women

T cell killing by tolerogenic dendritic cells protects mice from allergy

Changes in the expression of interleukin-1β and lipopolysaccharide-induced TNF factor in the oviduct of laying hens in response to artificial insemination

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