TNF-α, CXCL-1 and IL-1 β as activators of the opioid system involved in peripheral analgesic control in mice

Quintão, Jayane L D; Gonzaga, Amanda Cristina Reis; Galdino, Giovane; Romero, Thiago Roberto Lima; Silva, JosianeFernandes; Lemos, Virgı́nia S.; Campolina-Silva, Gabriel Henrique; Oliveira, Cleida A.; Mahecha, GermánArturo Bohórquez; Duarte, IgorDimitri Gama

doi:10.1016/j.ejphar.2021.173900

Cited by 6 publications

(4 citation statements)

References 29 publications

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“…Together, these factors promote cellular processes such as chemotaxis, increased vascular permeability and hyperalgesia. IL-1β is directly related to increased excitability and sensitization of nociceptive endings, in addition to inducing apoptosis in the responses of inflammatory and carcinogenic processes [66]. These cytokines, as well as endotoxins, such as lipopolysaccharides (LPS), promote the activation of the endothelium cells through the Toll-like receptor 4 (TLR4) and the RIG-I pathway, which promotes cytokine secretion and the expression of molecules of adhesion, such as E-selectin, VCAM-1 and ICAM-1 to facilitate leukocyte extravasation.…”

Section: Discussionmentioning

confidence: 99%

The Compound (E)-2-Cyano-N,3-diphenylacrylamide (JMPR-01): A Potential Drug for Treatment of Inflammatory Diseases

et al. 2022

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The compound (E)-2-cyano-N,3-diphenylacrylamide (JMPR-01) was structurally developed using bioisosteric modifications of a hybrid prototype as formed from fragments of indomethacin and paracetamol. Initially, in vitro assays were performed to determine cell viability (in macrophage cultures), and its ability to modulate the synthesis of nitrite and cytokines (IL-1β and TNFα) in non-cytotoxic concentrations. In vivo, anti-inflammatory activity was explored using the CFA-induced paw edema and zymosan-induced peritonitis models. To investigate possible molecular targets, molecular docking was performed with the following crystallographic structures: LT-A4-H, PDE4B, COX-2, 5-LOX, and iNOS. As results, we observed a significant reduction in the production of nitrite and IL-1β at all concentrations used, and also for TNFα with JMPR-01 at 50 and 25 μM. The anti-edematogenic activity of JMPR-01 (100 mg/kg) was significant, reducing edema at 2–6 h, similar to the dexamethasone control. In induced peritonitis, JMPR-01 reduced leukocyte migration by 61.8, 68.5, and 90.5% at respective doses of 5, 10, and 50 mg/kg. In silico, JMPR-01 presented satisfactory coupling; mainly with LT-A4-H, PDE4B, and iNOS. These preliminary results demonstrate the strong potential of JMPR-01 to become a drug for the treatment of inflammatory diseases.

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Section: Discussionmentioning

confidence: 99%

The Compound (E)-2-Cyano-N,3-diphenylacrylamide (JMPR-01): A Potential Drug for Treatment of Inflammatory Diseases

et al. 2022

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“…Hasil penelitian terlihat kelompok kontrol negatif terus mengalami peningkatan udema (%R) mulai dari menit ke 0 sampai menit ke 180. Pada injeksi karagenan ini terjadi perubahan inflamasi berupa peningkatan opioid peptida dan marker transkripsi (Bruera & Portenoy, 2009;Quintão et al, 2021). Tanda kardinal dari inflamasi yang terjadi akibat injeksi karagenan secara subkutan adalah edema, hiperalgesia, dan eritema (Jorge et al, 2006;Owusu et al, 2023).…”

Section: Hasil Pengujian Antiinflamasiunclassified

Potensi Ekstrak Etanol Kulit Batang Jabon (Anthocephalus cadamba (Roxb) Miq.) Sebagai Antiinflamasi

Bakri,

Rusnaeni,

Sasarari

et al. 2024

J. Biol Papua

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This study investigates the anti-inflammatory properties of an ethanol extract from Jabon plant stem bark in male mice using the Rat Hind Paw Edema method. Twenty-five male mice were divided into five groups: negative control (Na-CMC 1%), positive control (mefenamic acid), and three groups receiving the extract at doses of 50 mg/kg, 100 mg/kg, and 200 mg/kg. Measurements were taken every 30 minutes for three hours using a plethysmometer. Analysis with one-way ANOVA and Duncan's test revealed significant anti-inflammatory effects for all doses, with the most effective being 100 mg/kg, showing 93.42% inhibition. The results suggest Jabon plant extract as a promising anti-inflammatory agent.

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“…83 Moreover, CXCL1 induces the release of endogenous opioid peptides in inflammation. 84 In a previous study on rheumatoid arthritis, Xu et al used multiple enzyme-linked immunosorbent assays (ELISAs) to determine the cytokines/chemokines that are involved in anti-injury effects of acupuncture and moxibustion. Only CXCL1 was found to be markedly elevated at multiple time points as acupuncture effectively alleviated inflammatory pain.…”

Section: Peripheral Mechanismsmentioning

confidence: 99%

Mechanisms of acupuncture–electroacupuncture on inflammatory pain

Zhang,

Zhou,

Huo

et al. 2023

Mol Pain

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Acupuncture, as a traditional treatment, has been extensively used in China for thousands of years. According to the World Health Organization (WHO), acupuncture is recommended for the treatment of 77 diseases. And sixteen of these diseases are related to inflammatory pain. As a combination of traditional acupuncture and modern electrotherapy, electroacupuncture (EA) has satisfactory analgesic effects on various acute and chronic pain. Because of its good analgesic effects and no side effects, acupuncture has been widely accepted all over the world. Despite the increase in the number of studies, the mechanisms via which acupuncture exerts its analgesic effects have not been conclusively established. A literature review of related research is of great significance to elaborate on its mechanisms and to inform on further research directions. We elucidated on its mechanisms of action on inflammatory pain from two levels: peripheral and central. It includes the mechanisms of acupuncture in the periphery (immune cells and neurons, purinergic pathway, nociceptive ion channel, cannabinoid receptor and endogenous opioid peptide system) and central nervous system (TPRV1, glutamate and its receptors, glial cells, GABAergic interneurons and signaling molecules ). In this review, we collected relevant recent studies to systematically explain the mechanisms of acupuncture in treating inflammatory pain, with a view to providing direction for future applications of acupuncture in inflammatory pain and promoting clinical development.

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TNF-α, CXCL-1 and IL-1 β as activators of the opioid system involved in peripheral analgesic control in mice

Cited by 6 publications

References 29 publications

The Compound (E)-2-Cyano-N,3-diphenylacrylamide (JMPR-01): A Potential Drug for Treatment of Inflammatory Diseases

The Compound (E)-2-Cyano-N,3-diphenylacrylamide (JMPR-01): A Potential Drug for Treatment of Inflammatory Diseases

Potensi Ekstrak Etanol Kulit Batang Jabon (Anthocephalus cadamba (Roxb) Miq.) Sebagai Antiinflamasi

Mechanisms of acupuncture–electroacupuncture on inflammatory pain

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