TNF-α-308/-238 polymorphisms are associated with gastric cancer: A case-control family study in China

Xu, Yajuan; Cao, Xiaoqin; Jiang, Jian; Chen, Yi; Wang, Kaijuan

doi:10.1016/j.clinre.2016.05.014

Cited by 15 publications

(19 citation statements)

References 36 publications

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“…However, other reports from Beijing (10) and Hubei province (7) showed a lower prevalence of heterozygous mutations (8-9%). Interestingly, the distribution of TNF-α (-308G>A) genotypes deviated from HWE in all earlier reports including the present study in a Chinese population (7)(8)(9)(10)(11)(12)(13)36). Deviation of a genotype distribution from HWE has been attributed to genotyping error, population stratification, or selection pressure.…”

Section: Discussionsupporting

confidence: 45%

“…Deviation of a genotype distribution from HWE has been attributed to genotyping error, population stratification, or selection pressure. The present study and earlier reports enrolled controls from an ethnic group and employed robust genotyping methods (7)(8)(9)(10)(11)(12)(13)36). Deviation from HWE is possibly due to prevalence of various infectious diseases in Chinese populations, which applies selection pressure on the human genome (41).…”

Section: Discussionmentioning

confidence: 99%

“…Various studies have been conducted in different populations of China to identify a possible association of TNF-α -308G>A with the development of GC (7)(8)(9)(10)(11)(12)(13)36). Most of the studies showed an association of variants with susceptibility to GC.…”

Section: Discussionmentioning

confidence: 99%

“…The most recent meta-analyses were reported in the year 2014 (46,49,51). In the present study, five recent case-control studies investigating the role of TNF-α -308G>A in GC susceptibility were included, leading to an analysis including a much larger number of cases (n=8353) and controls (n=12099) (13,14,16,28,29).…”

Section: Discussionmentioning

confidence: 99%

“…An association of TNF-α -308G>A (rs1800629) with susceptibility/resistance to GC development has been widely investigated and yielded conflicting results. Studies including GC patients and controls from China (7)(8)(9)(10)(11)(12)(13)(14), Brazil (15,16), Portugal (17,18), United States (19), Poland (20), South Korea (21-23), Honduras (24), Italy (25), Colombia (26), and Japan (27) have been associated with susceptibility to GC development. However, other studies including those from India (28), Brazilian (29,30), Romania (31), Spain (32,33), South Korea (34,35), China (36), Mexico (37), Germany (38) and Finland (39) failed to show a possible link between the TNF-α (-308G>A) polymorphism and GC.…”

Section: Introductionmentioning

confidence: 99%

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Role of TNF-α -308G/A gene polymorphism in gastric cancer risk: A case control study and meta-analysis

Du¹,

Gao²

2017

Turk J Gastroenterol

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Background/Aims: In the Chinese population, gastric cancer (GC) is ranked as the third most common type of cancer. Although the exact etiology of GC development is unclear, several factors, including genetic and environmental, have been identified as risk factors. Variations in cytokine genes and their receptors have been related to a higher risk of GC. A single nucleotide polymorphism in the promoter region of tumor necrosis factor-α (TNF-α) (-308G>A) has been associated with a higher risk of GC and in the present study we evaluated its possible association with GC in a Chinese cohort. In addition, we performed a meta-analysis to draw a firm conclusion about the association between TNF-α gene polymorphisms and GC. Materials and Methods: We enrolled 400 Chinese GC patients and matched healthy controls hailing from similar geographical areas. The TNF-α -308G/A polymorphism was genotyped by allele-specific polymerase chain reaction (AS-PCR). For the meta-analysis, earlier published articles were searched and eligible studies were included. Results: Prevalence of the heterozygous mutant (GA) and minor allele (A) were significantly higher in GC cases compared to healthy controls (GA: p<0.0001, odds ratio (OR)=4.90; A: p<0.0001, OR=2.84). A total of 36 eligible studies including the present report, encompassing of 8353 GC patients and 12099 controls, were analyzed for the meta-analysis. A significant association of the TNF-α polymorphism (-308G>A) with susceptibility to GC was only found in the Caucasian population (A vs G: p=0.001; AA vs GG: p=0.01; AG vs GG: p<0.0001; AA vs AG+GG: p=0.01; AA+AG vs p=0.003). Conclusion:The results of the present case control study and meta-analysis showed that associations between TNF-a variants with susceptibility to GC development is population and ethnic specific. Keywords: Gene polymorphism, TNF-α, gastric cancer, meta-analysis, association, Chinese Original ArticleCite this article as: Du LC, Gao R. Role of TNF-α -308G/A gene polymorphism in gastric cancer risk: a case control study and metaanalysis. Turk J Gastroenterol 2017; 28: 272-82.

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