“…If chronic allograft nephropathy (CAN) was diagnosed by biopsy, the most common first step in management was a dose reduction in calcineurin inhibition. All biopsies were reviewed by pathologists using Banff criteria independent of the polymorphism analysis [11].…”
Section: Allograft Functionmentioning
confidence: 99%
“…For instance, TNF-a may be very significant in the context of acute rejection; whereas transforming growth factor-beta (TGF-b) may play a more prominent role in chronic allograft dysfunction, although its potential involvement potentially in acute rejection is not to be discounted [10][11][12]. Chemokines also certainly play an important role in transplant rejection [13,14].…”
These data suggest that many of the donor polymorphisms studied in this analysis may influence a recipient's immune response to a renal allograft. However, their greatest impact may be demonstrated in long-term outcomes.
“…If chronic allograft nephropathy (CAN) was diagnosed by biopsy, the most common first step in management was a dose reduction in calcineurin inhibition. All biopsies were reviewed by pathologists using Banff criteria independent of the polymorphism analysis [11].…”
Section: Allograft Functionmentioning
confidence: 99%
“…For instance, TNF-a may be very significant in the context of acute rejection; whereas transforming growth factor-beta (TGF-b) may play a more prominent role in chronic allograft dysfunction, although its potential involvement potentially in acute rejection is not to be discounted [10][11][12]. Chemokines also certainly play an important role in transplant rejection [13,14].…”
These data suggest that many of the donor polymorphisms studied in this analysis may influence a recipient's immune response to a renal allograft. However, their greatest impact may be demonstrated in long-term outcomes.
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