TNF-related apoptosis-inducing ligand: Signalling of a ‘smart’ molecule

Manzo, Fabio; Nebbioso, Angela; Miceli, Marco; Conte, Mariarosaria; Bellis, Floriana De; Carafa, Vincenzo; Franci, Gianluigi; Tambaro, Francesco Paolo; Altucci, Lucia

doi:10.1016/j.biocel.2007.12.012

Cited by 25 publications

(15 citation statements)

References 32 publications

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“…Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily and is primarily known to involve in the process of apoptosis preferentially in cancer cells through its interaction with death receptors [1,2]. On the other hand, the possible roles of TRAIL in the cardiovascular system have not been fully elucidated.…”

Section: Introductionmentioning

confidence: 98%

Low serum TNF-related apoptosis-inducing ligand (TRAIL) levels are associated with acute ischemic stroke severity

Kang¹,

Park²,

Noh³

et al. 2015

Atherosclerosis

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Section: Introductionmentioning

confidence: 98%

Low serum TNF-related apoptosis-inducing ligand (TRAIL) levels are associated with acute ischemic stroke severity

Kang¹,

Park²,

Noh³

et al. 2015

Atherosclerosis

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“…TNF-related ligand, TRAIL, is a member of the TNF superfamily of cytokines and it is capable of inducing apoptosis in a variety of transformed cells in vitro (21). TRAIL may have an important role in the regulation of immune responses, inflammation and allergy (10).…”

Section: Introductionmentioning

confidence: 99%

“…TRAIL is expressed in a variety of human tissues, in particular in the lymphoid system, suggesting a strong physiological role in the innate immunity (10). In this report, we investigated the possible association between pathogenesis of the BD and the TNF-α gene 308A/G (rs1800629) polymorphism and TRAIL gene [Arg141His, G422A (rs6557634), Thr209Arg, C626G (rs20575) and Glu228Ala, A683C (rs20576)] polymorphisms in BD patients and healthy subjects.…”

Section: Introductionmentioning

confidence: 99%

The Tumor Necrosis Factor-A (TNF-A) Gene -308 G/A Polymorphism and the Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (Trail) Gene Polymorphisms in Behcet'S Disease

Isi

Akdeniz

Oral

et al. 2010

Biotechnology & Biotechnological Equipment

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“…TRAIL is a member of the TNF family of cytokines, which induces apoptosis of a variety of tumor cells by engaging the death receptors DR4 and DR5, despite displaying no cytotoxicity against most normal cells; this makes it a promising new agent for cancer therapy (32)(33)(34). Although TRAIL is constitutively expressed in a wide variety of normal tissues, its main role appears to be in the immune system.…”

mentioning

confidence: 99%

The Calcineurin B Subunit (CnB) Is a New Ligand of Integrin αM That Mediates CnB-Induced Apo2L/TRAIL Expression in Macrophages

Liu

Xin

et al. 2012

The Journal of Immunology

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We showed previously that the calcineurin B subunit (CnB) plays an important role in activation of peritoneal macrophage, but the underlying mechanism remained unknown. To examine whether there is a CnB receptor on peritoneal macrophages, we performed the radioligand binding assay of receptors. The receptor saturation binding curve demonstrated high-affinity and specific binding; the maximum binding was 1090 fmol/105 cells, and the Kd was 70.59 pM. Then, we used a CnB affinity resin to trap potential receptors from highly purified peritoneal macrophage membranes. Mass spectrometry analysis showed that the binding protein was mouse integrin αM. We next performed a competition binding experiment to confirm the binding of CnB to integrin αM. This showed that FITC-CnB bound specifically to peritoneal macrophages and that binding was blocked by the addition of integrin αM Ab. We observed that CnB could induce TRAIL gene expression in peritoneal macrophages in vitro and in vivo. Integrin αM Ab blocking, RNA interference, and ligand competition experiments demonstrated that CnB-induced TRAIL expression is dependent on integrin αM. Furthermore, the tumoricidal activity of CnB-activated peritoneal macrophages is partially dependent on TRAIL. In addition, CnB treatment significantly prolongs the survival of mice bearing H22 ascites tumors, which has a positive correlation with the induction level of TRAIL. These results reveal a novel function of the CnB in innate immunity and cancer surveillance. They also point to a new signaling pathway leading to induction of TRAIL and suggest a possible application of CnB in cancer therapy.

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TNF-related apoptosis-inducing ligand: Signalling of a ‘smart’ molecule

Cited by 25 publications

References 32 publications

Low serum TNF-related apoptosis-inducing ligand (TRAIL) levels are associated with acute ischemic stroke severity

Low serum TNF-related apoptosis-inducing ligand (TRAIL) levels are associated with acute ischemic stroke severity

The Tumor Necrosis Factor-A (TNF-A) Gene -308 G/A Polymorphism and the Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (Trail) Gene Polymorphisms in Behcet'S Disease

The Calcineurin B Subunit (CnB) Is a New Ligand of Integrin αM That Mediates CnB-Induced Apo2L/TRAIL Expression in Macrophages

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