Tn5053, a Mercury Resistance Transposon with Integron's Ends

Kholodii, Gennady; Yurieva, Olga; Lomovskaya, Olga; Gorlenko, Zhosephine; Mindlin, S. Z.; Nikiforov, Vadim

doi:10.1006/jmbi.1993.1228

Cited by 72 publications

(59 citation statements)

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“…These are Tn21-subgroup transposons (Pearson et al, 1996; this study), Tn5041-type transposons (this study), and Tn5053-type transposons (Kholodii et al, 1993b;Hobman et al, 1994;S. Minakhina et al, in preparation).…”

Section: Discussionmentioning

confidence: 74%

Intercontinental spread of promiscuous mercury‐resistance transposons in environmental bacteria

Yurieva

Kholodii

Minakhin

et al. 1997

Molecular Microbiology

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SummaryWe demonstrate that horizontal spread of mer operons similar to worldwide spread of antibiotic-resistance genes in medically important bacteria occurred in bacteria found in ores, soils and waters. The spread was mediated by different transposons and plasmids. Some of the spreading transposons were damaged in different ways but this did not prevent their further spread. Certain transposons are mosaics composed of segments belonging to distinct sequence types. These mosaics arose as a result of homologous and site-specific recombination. Our data suggest that the mercury-resistance operons of Gram-negative environmental bacteria can be considered as a worldwide population composed of a relatively small number of distinct recombining clones shared, at least partially, by environmental and clinical bacteria.

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Section: Discussionmentioning

confidence: 74%

Intercontinental spread of promiscuous mercury‐resistance transposons in environmental bacteria

Yurieva

Kholodii

Minakhin

et al. 1997

Molecular Microbiology

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“…Recent studies demonstrate considerable diversity in Gram-negative bacterial mer operons at the DNA sequence level (Kholodii et al, 1993a(Kholodii et al, , 1995Osborn et al, 1995Osborn et al, ,1996Yurieva et al, 1997;Liebert et al, 1997), but at the same time there is evidence of a wide geographical distribution of the same sequences. The geographical spread of mer operons has been accompanied by horizontal transfer between different bacterial genera (Yurieva et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Horizontal spread of mer operons among Gram-positive bacteria in natural environments

et al. 1998

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Horizontal dissemination of the genes responsible for resistance to toxic pollutants may play a key role in the adaptation of bacterial populations to environmental contaminants. However, the frequency and extent of gene dissemination in natural environments is not known. A natural horizontal spread of two distinct mercury resistance (mer) operon variants, which occurred amongst diverse Bacillus and related species over wide geographical areas, is reported. One mer variant encodes a mercuric reductase with a single N-terminal domain, whilst the other encodes a reductase with a duplicated Nterminal domain. The strains containing the former mer operon types are sensitive to organomercurials, and are most common in the terrestrial mercury-resistant Bacillus populations studied in this work. The strains containing the latter operon types are resistant to organomercurials, and dominate in a Minamata Bay mercury-resistant Bacillus population, previously described in the literature. A t least three distinct transposons (related to a class II vancomycin-resistance transposon, Tn1546, from a clinical Enterococcus strain) and conjugative plasmids are implicated as mediators of the spread of these mer operons.

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“…Bacterial mercury resistance has been found in a wide range of Gramnegative and Gram-positive bacteria. The operon varies in the number of genes present and is usually located on plasmids (3,5,8,19,25) and chromosomes (4,13,18,28); they are often components of transposons (5,11,15,20) and integrons (4,13,18) in a striking diversity of arrangements, often involving duplications and distributions of the enzymes, transporters or regulators among several replicons in one cell. Moreover, two major mer genes, the regulator merR and the merA, which codes the NADPH-dependent flavoenzyme mercuric reductase [E.C.…”

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confidence: 99%

A conservative region of the mercuric reductase gene (merA) as a molecular marker of bacterial mercury resistance

Sotero-Martins¹,

Jesus²,

Lacerda³

et al. 2008

Braz. J. Microbiol.

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Tn5053, a Mercury Resistance Transposon with Integron's Ends

Cited by 72 publications

References 0 publications

Intercontinental spread of promiscuous mercury‐resistance transposons in environmental bacteria

Intercontinental spread of promiscuous mercury‐resistance transposons in environmental bacteria

Horizontal spread of mer operons among Gram-positive bacteria in natural environments

A conservative region of the mercuric reductase gene (merA) as a molecular marker of bacterial mercury resistance

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