TN strain proteome mediated therapeutic target mapping and multi-epitopic peptide-based vaccine development for Mycobacterium leprae

Comparative genomics, evolutionary epidemiology, and RBD-hACE2 receptor binding pattern in B.1.1.7 (Alpha) and B.1.617.2 (Delta) related to their pandemic response in UK and India

“…Recently, Calcagnile et al have used the HDOCK server in their molecular docking study to understand the hACE2 gene polymorphism, which can interfere with the interaction landscape between the SARS-CoV-2 spike and hACE2 ( Calcagnile et al, 2021 ). Bhattacharya et al have used the HDOCK server in several studies to perform the protein-protein interaction ( Bhattacharya et al, 2020a ; Bhattacharya et al, 2020b ; Bhattacharya et al, 2021b ; Bhattacharya et al, 2022a ).…”

A novel mutation-proof, next-generation vaccine to fight against upcoming SARS-CoV-2 variants and subvariants, designed through AI enabled approaches and tools, along with the machine learning based immune simulation: A vaccine breakthrough

“…The ProSA web server predicted the ‘Z’ score as a negative value (−2.86). It suggests the standing signal for the protein structural configuration quality assessment [ 66 ]. Additionally, the analysis of the local quality model of residues is considered a consistent model.…”

Designing, characterization, and immune stimulation of a novel multi-epitopic peptide-based potential vaccine candidate against monkeypox virus through screening its whole genome encoded proteins: An immunoinformatics approach

“…The 3D structure was also critically validated by ProSA and PROCHECK web servers, where the local energy plot and ‘Z’ score were accessed to understand the proper folding of the protein. The ProSA server predicted a ‘Z’ score negative value (−2.78), signifying an upright signal for the structural quality assessment [ 41 ]. Along with the analysis of the local quality model, this model has been considered as a reliable model.…”