Tn as a potential predictor for regional lymph node metastasis in T1 colorectal cancer

Kuo, Li-Jen; Fang, Chih‐Yeu; Lin, Yen-Kuang; Wei, Po‐Li; Kung, Ching Huei; Chen, Chi Long

doi:10.1016/j.asjsur.2023.04.112

Cited by 1 publication

(1 citation statement)

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“…According to the Korean clinical practice guidelines, risk factors for LNM in early CRC include a poor histologic type, deep submucosal invasion, LVI, and tumor budding, and additional surgery is recommended if any of these risk factors are listed in the pathologic report [23]. In a recent study, the authors predicted LNM in T1 CRC based on Tn (a type of tumor-associated carbohydrate antigen) as a molecular marker [24].…”

Section: Introductionmentioning

confidence: 99%

A Retrospective Multicenter Study of Risk Factors, Stratification, and Prognosis of Lymph Node Metastasis in T1 and T2 Colorectal Cancer

Kim,

Son,

Kim

et al. 2023

JCM

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Background. The objective of this study was to compare the long-term prognosis of patients with T1 and T2 colorectal cancer (CRC) according to lymph node metastasis (LNM) and to identify risk factors for LNM. Methods. We retrospectively reviewed patients who underwent curative resection for T1 or T2 CRC at five University-affiliated hospitals between January 2012 and December 2021. The patients were divided into several groups depending on the presence of LNM or the number of risk factors. Results. Of the total 765 patients, 87 (11.3%) patients had LNM. These patients had poorer recurrence-free survival (RFS) than patients without LNM (72.6% vs. 88.6%). The multivariable analysis showed that high-grade tumors (p = 0.003), lymphovascular invasion (p < 0.001), and rectal location (p = 0.049) were independent predictors of LNM. When divided into groups according to the number of the three risk factors, the risk of LNM increased from 5.4% (ultralow-risk group; no risk factor) to 60.0% (high-risk group; all three risk factors) and the 5-year RFS rate decreased from 96.3% in the ultralow-risk group to 60% in the high-risk group (p < 0.001). Conclusion. Radical surgery should be considered for T1 and T2 CRC patients with these risk factors.

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Section: Introductionmentioning

confidence: 99%