TMEM258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation

Graham, Daniel B.; Lefkovith, Ariel; Deelen, Patrick; Klein, Niek de; Varma, Mukund; Boroughs, Angela C.; Desch, A. Nicole; Ng, Aylwin; Guzman, Gaelen; Schenone, Monica; Petersen, Christine; Bhan, Atul K.; Rivas, Manuel A.; Daly, Mark J.; Carr, Steven A.; Wijmenga, Cisca; Xavier, Ramnik J.

doi:10.1016/j.celrep.2016.11.042

Cited by 45 publications

(40 citation statements)

References 42 publications

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“…The large noncoding RNA ANRIL (antisense noncoding RNA in the INK4 locus), which is associated with cancers and metastasis, positively regulates the expression of TMEM258 ( Bochenek et al, 2013 ; Qiu et al, 2015 ). Graham et al (2016) recently reported that increased TMEM258 expression is associated with inflammatory bowel disease. Further studies should examine whether the pathology of TMEM258-associated diseases involves alterations of the LINC complex and NE architecture.…”

Section: Discussionmentioning

confidence: 99%

Outer nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture

Ding

Wang

Huang

et al. 2017

Journal of Cell Biology

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Section: Discussionmentioning

confidence: 99%

Outer nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture

Ding

Wang

Huang

et al. 2017

Journal of Cell Biology

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“…Prdx5 was ectopically expressed in HEK293T cells as previously described (Graham et al, 2016). Briefly, cDNA constructs were cloned as PCR products into pCMV (Invitrogen) using Gibson assembly.…”

Section: Methodsmentioning

confidence: 99%

Nitric Oxide Engages an Anti-inflammatory Feedback Loop Mediated by Peroxiredoxin 5 in Phagocytes

et al. 2018

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SUMMARY Phagocyte microbiocidal mechanisms and inflammatory cytokine production are temporally coordinated, although their respective interdependencies remain incompletely understood. Here, we identify a nitric-oxide-mediated antioxidant response as a negative feedback regulator of inflammatory cytokine production in phagocytes. In this context, Keap1 functions as a cellular redox sensor that responds to elevated reactive nitrogen intermediates by eliciting an adaptive transcriptional program controlled by Nrf2 and comprised of antioxidant genes, including Prdx5. We demonstrate that engaging the antioxidant response is sufficient to suppress Toll-like receptor (TLR)-induced cytokine production in dendritic cells and that Prdx5 is required for attenuation of inflammatory cytokine production. Collectively, these findings delineate the reciprocal regulation of inflammation and cellular redox systems in myeloid cells.

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“…2a, right panel). TMEM258 catalyzes the first step in Nglycosylation of proteins in the ER and might play a role in protein translocation across the ER 29 .…”

Section: Multiple Layers Of Functional Relationships Between Proteinsmentioning

confidence: 99%

A reference map of the human protein interactome

Luck

Kim

Lambourne

et al. 2019

Preprint

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Global insights into cellular organization and function require comprehensive understanding of interactome networks. Similar to how a reference genome sequence revolutionized human genetics, a reference map of the human interactome network is critical to fully understand genotype-phenotype relationships. Here we present the first human "all-by-all" binary reference interactome map, or "HuRI". With ~53,000 highquality protein-protein interactions (PPIs), HuRI is approximately four times larger than the information curated from small-scale studies available in the literature. Integrating HuRI with genome, transcriptome and proteome data enables the study of cellular function within essentially any physiological or pathological cellular context. We demonstrate the use of HuRI in identifying specific subcellular roles of PPIs and protein function modulation via splicing during brain development. Inferred tissue-specific networks reveal general principles for the formation of cellular context-specific functions and elucidate potential molecular mechanisms underlying tissue-specific phenotypes of Mendelian diseases. HuRI thus represents an unprecedented, systematic reference linking genomic variation to phenotypic outcomes.

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TMEM258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation

Cited by 45 publications

References 42 publications

Outer nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture

Outer nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture

Nitric Oxide Engages an Anti-inflammatory Feedback Loop Mediated by Peroxiredoxin 5 in Phagocytes

A reference map of the human protein interactome

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