Abstract:Animal and in vitro studies suggest that transmembrane member 16A (TMEM16A), a Ca 2+ -activated Cl − channel, contributes to regulating eccrine sweating. However, direct evidence supporting this possibility in humans is lacking. We assessed the hypothesis that TMEM16A blockers attenuate sweating during whole-body heating in humans. Additionally, we assessed the associated changes in the heat loss response of cutaneous vasodilatation to determine if a functional role of TMEM16A may exist.Twelve young (24 ± 2 ye… Show more
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