TMEM166 inhibits cell proliferation, migration and invasion in hepatocellular carcinoma via upregulating TP53

Enhanced Efficacy and Increased Long-Term Toxicity of CNS-Directed, AAV-Based Combination Therapy for Krabbe Disease

“…The integrated vectors largely appeared to be rearranged such that the identified break points within the integrated AAV sequences occurred in the 5 0 portion of the vector (Table S2). Several animals had additional AAV integrations in or near genes associated with HCC and other malignancies (Akap13; 25 Figures S2B and S2C), that affect cell growth or death (Kcnh1 26 and Eva1a; 27 Figures S2D and S2E), or that are tumor suppressors (Foxp1, 28,29 Tusc3, 30 Magi1; 31,32 Figures S2F and S2G). In fact, one animal (6675) with an integration in Rian also had intragenic integrations in both Foxp1 and Tusc3, which are known and candidate tumor suppressors, respectively.…”

Flubendazole induces mitochondrial dysfunction and DRP1-mediated mitophagy by targeting EVA1A in breast cancer

“…EVA1A, an endoplasmic reticulum-associated protein, interacts with ATG16L1 and promotes ATG12-ATG5/ATG16L1 complex recruitment to the autophagic membrane and enhances the autophagosome formation [ 50 ]. Moreover, EVA1A induces cell death in many tumors via regulating autophagic and apoptotic mechanisms [ 51 – 56 ]. We previously reported that flubendazole could restore the expression of EVA1A in TNBC cells, therefore inducing autophagic cell death and eliciting anti-cancer effects [ 26 ].…”

Knockdown of FAM225B inhibits the progression of the hypertrophic scar following glaucoma surgery by inhibiting autophagy

“…Apoptosis is closely associated with autophagy in types of cancer, including hepatocellular carcinoma ( 43 , 44 ). Importantly, autophagy is necessary for the onset of apoptosis, which usually triggers the occurrence of cell apoptosis and injury ( 45 , 46 ).…”