TMED3 promotes prostate cancer via FOXO1a and FOXO3a phosphorylation
XIUWANG WEI,
JIANBO LIANG,
HUANWEN HUANG
et al.
Abstract:Background: Transmembrane emp24 trafficking protein 3 (TMED3) is associated with the development of several tumors; however, whether TMED3 regulates the progression of prostate cancer remains unclear. Materials and Methods: Short hairpin RNA was performed to repress TMED3 in prostate cancer cells (DU145 cells) and in a prostate cancer mice model to determine its function in prostate cancer in vitro and in vivo. Results: In the present study, we found that TMED3 was highly expressed in prostate cancer cells. In… Show more
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