2024
DOI: 10.3389/fgene.2024.1285305
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TMBcalc: a computational pipeline for identifying pan-cancer Tumor Mutational Burden gene signatures

Grete Francesca Privitera,
Salvatore Alaimo,
Anna Caruso
et al.

Abstract: Background:In the precision medicine era, identifying predictive factors to select patients most likely to benefit from treatment with immunological agents is a crucial and open challenge in oncology.Methods:This paper presents a pan-cancer analysis of Tumor Mutational Burden (TMB). We developed a novel computational pipeline, TMBcalc, to calculate the TMB. Our methodology can identify small and reliable gene signatures to estimate TMB from custom targeted-sequencing panels. For this purpose, our pipeline has … Show more

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