TM4SF19-AS1 facilitates the proliferation of lung squamous cell carcinoma by recruiting WDR5 to mediate TM4SF19

Luo, Machang; Xie, Lingyan; Su, Yonghua; Zhang, Kaijun; Liang, Rongzhang; Ma, Zhiyong; Li, Youtang

doi:10.1016/j.mcp.2022.101849

Cited by 5 publications

(7 citation statements)

References 28 publications

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“…Like TM4SF19, TM4SF19-AS1 can promote LSCC cell proliferation and adhesion. Moreover, there was a markedly positive correlation between TM4SF19-AS1 and TM4SF19 levels [158].…”

Section: Heterogeneous Nuclear Ribonucleoproteins With Rbp Functionmentioning

confidence: 88%

“…Facilitates proliferation, adhesion of lung squamous cell carcinoma [158] METTL3→m 6 A-DLGAP1-AS2↑stab +YTHDF1(m 6 A-reader RBP)→c-Myc↑mRNAstab Promotes aerobic glycolysis; correlated with advanced stages, poor prognosis [159] Note: stab-stability; ov-ex-overexpression; demeth-pr-demethylated promoter; meth-methylation; DFS-disease-free survival; OS-overall survival; PFS-progression-free survival; p-w-pathway; phosphphosphorylation; sign-signaling; ↑ ↓-increase or decrease in expression or stabilization; →-activation; /inhibition; ↔-a positive feedback.…”

Section: Macc1-as1+upf1(rbp)→lats1/2↓mrnadestabmentioning

confidence: 99%

“…Another example of RBP-dependent regulation of a protein-coding gene by an adjacent complementary antisense transcript is the TM4SF19 gene (transmembrane 4 L six family member 19). It is regulated by the conservative lncRNA TM4SF19-AS1 encoded by the TM4SF19 gene cluster, located at chromosome 3q29, and depends on WDR5 (WD repeat-containing protein 5) [158]. TM4SF19-AS1, like TM4SF19, was both upregulated in cells and patients' tissues of lung squamous cell carcinoma (LSCC).…”

Section: Heterogeneous Nuclear Ribonucleoproteins With Rbp Functionmentioning

confidence: 99%

See 2 more Smart Citations

Various LncRNA Mechanisms in Gene Regulation Involving miRNAs or RNA-Binding Proteins in Non-Small-Cell Lung Cancer: Main Signaling Pathways and Networks

Braga,

Fridman,

Burdennyy

et al. 2023

IJMS

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Long non-coding RNAs (lncRNAs) are crucial players in the pathogenesis of non-small-cell lung cancer (NSCLC). A competing binding of lncRNAs and mRNAs with microRNAs (miRNAs) is one of the most common mechanisms of gene regulation by lncRNAs in NSCLC, which has been extensively researched in the last two decades. However, alternative mechanisms that do not depend on miRNAs have also been reported. Among them, the most intriguing mechanism is mediated by RNA-binding proteins (RBPs) such as IGF2BP1/2/3, YTHDF1, HuR, and FBL, which increase the stability of target mRNAs. IGF2BP2 and YTHDF1 may also be involved in m6A modification of lncRNAs or target mRNAs. Some lncRNAs, such as DLGAP1-AS2, MALAT1, MNX1-AS1, and SNHG12, are involved in several mechanisms depending on the target: lncRNA/miRNA/mRNA interactome and through RBP. The target protein sets selected here were then analyzed using the DAVID database to identify the pathways overrepresented by KEGG, Wikipathways, and the Reactome pathway. Using the STRING website, we assessed interactions between the target proteins and built networks. Our analysis revealed that the JAK-STAT and Hippo signaling pathways, cytokine pathways, the VEGFA-VEGFR2 pathway, mechanisms of cell cycle regulation, and neovascularization are the most relevant to the effect of lncRNA on NSCLC.

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“…Like TM4SF19, TM4SF19-AS1 can promote LSCC cell proliferation and adhesion. Moreover, there was a markedly positive correlation between TM4SF19-AS1 and TM4SF19 levels [158].…”

Section: Heterogeneous Nuclear Ribonucleoproteins With Rbp Functionmentioning

confidence: 88%

Section: Macc1-as1+upf1(rbp)→lats1/2↓mrnadestabmentioning

confidence: 99%

Section: Heterogeneous Nuclear Ribonucleoproteins With Rbp Functionmentioning

confidence: 99%

See 1 more Smart Citation

Various LncRNA Mechanisms in Gene Regulation Involving miRNAs or RNA-Binding Proteins in Non-Small-Cell Lung Cancer: Main Signaling Pathways and Networks

Braga,

Fridman,

Burdennyy

et al. 2023

IJMS

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show abstract

“…Recent studies indicated that several lncRNAs, such as TM4SF19-AS1 , BLACAT2 and SATB2-AS1 and PTPRE-AS1 , could directly interact with WDR5 protein and serve as a guide to recruit chromatin regulatory complexes to target gene locus [ 40 – 43 ]. Consistent with the former studies, we proved that AC142119.1 transcript could not only bind with WDR5 protein, but also directly interact with the promoter region of MYCN .…”

Section: Discussionmentioning

confidence: 99%

LncRNA AC142119.1 facilitates the progression of neuroblastoma by epigenetically initiating the transcription of MYCN

Yang,

Liu,

et al. 2023

J Transl Med

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Background Oncogene MYCN is closely related with malignant progression and poor prognosis of neuroblastoma (NB). Recently, long non-coding RNAs (lncRNAs) have been recognized as crucial regulators in various cancers. However, whether lncRNAs contribute to the overexpression of MYCN in NB is unclear. Methods Microarray analysis were applied to analyze the differentially expressed lncRNAs between MYCN-amplified and MYCN-non-amplified NB cell lines. Bioinformatic analyses were utilized to identify lncRNAs nearby MYCN locus. qRT-PCR was used to detect the expression level of lncRNA AC142119.1 in NB cell lines and tissues. Gain- and loss-of-function assays were conducted to investigate the biological effect of AC142119.1 in NB. Fluorescence in situ hybridization, RNA pull-down, RNA immunoprecipitation, mass spectrometry, RNA electrophoretic mobility shift, chromatin immunoprecipitation and chromatin isolation by RNA purification assays were performed to validate the interaction between AC142119.1 and WDR5 protein as well as MYCN promoter. Results AC142119.1 was significantly elevated in NB tissues with MYCN amplification, advanced INSS stage and high risk, and associated with poor survival of NB patients. Moreover, enforced expression of AC142119.1 reinforced the proliferation of NB cells in vitro and in vivo. Additionally, AC142119.1 specifically recruited WDR5 protein to interact with MYCN promoter, further initiating the transcription of MYCN and accelerating NB progression. Conclusions We identified a novel lncRNA AC142119.1, which promoted the progression of NB through epigenetically initiating the transcription of MYCN via interacting with both WDR5 protein and the promoter of MYCN, indicating that AC142119.1 might be a potential diagnostic biomarker and therapeutic target for NB.

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“…TM4SF19 is associated with the occurrence and development of lung cancer [20]. More and more research indicates that the four-transmembrane L6 superfamily plays a crucial role in cancer prognosis; consequently, these molecules may be considered anticancer molecular targets.…”

Section: Introductionmentioning

confidence: 99%

TM4SF19 is a prognostic marker associated with immune invasion of bladder urothelial carcinoma

Liu,

Wang,

Wang

et al. 2024

Preprint

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Background Bladder Urothelial Carcinoma (BLCA) is a common urological cancer with significant morbidity and mortality. Thus, there is a need to discover novel biodiagnostic, therapeutic, and prognostic markers. The four-transmembrane L6 superfamily, which includes TM4SF19, has been implicated in cancer progression, but TM4SF19's role in BLCA remains unexplored. Method TM4SF19 expression was analyzed using data from TCGA databases. The cancer-promoting mechanism of TM4SF19 in BLCA was investigated by differential expression analysis, pathway enrichment analysis, immune infiltration analysis, and correlation analysis. The prognostic analysis of TM4SF19 in the TCGA-BLCA database was carried out to study its prognostic value. The mRNA expression of TM4SF19 was verified in bladder cancer cell lines and 30 peripheral blood samples of BLCA patients. The diagnostic value of TM4SF19 in the blood of BLCA patients was verified by receiver operating characteristic curve (ROC) analysis. Results TM4SF19 was found to be significantly overexpressed in BLCA cell lines, tumor tissue, and peripheral blood samples. ROC analysis indicated that TM4SF19 has diagnostic potential for BLCA patients. TM4SF19 expression was associated with immune cell infiltration, suggesting its impact on the tumor microenvironment. High TM4SF19 expression correlated with poor clinicopathological features and significantly reduced overall survival. Conclusion The upregulation of TM4SF19 has been observed to be correlated with the advancement of the disease and unfavorable prognosis. TM4SF19 is promised as a biomarker for the diagnosis and prognosis of BLCA patients, especially in peripheral blood testing.

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TM4SF19-AS1 facilitates the proliferation of lung squamous cell carcinoma by recruiting WDR5 to mediate TM4SF19

Cited by 5 publications

References 28 publications

Various LncRNA Mechanisms in Gene Regulation Involving miRNAs or RNA-Binding Proteins in Non-Small-Cell Lung Cancer: Main Signaling Pathways and Networks

Various LncRNA Mechanisms in Gene Regulation Involving miRNAs or RNA-Binding Proteins in Non-Small-Cell Lung Cancer: Main Signaling Pathways and Networks

LncRNA AC142119.1 facilitates the progression of neuroblastoma by epigenetically initiating the transcription of MYCN

TM4SF19 is a prognostic marker associated with immune invasion of bladder urothelial carcinoma

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