TLX activates MASH1 for induction of neuronal lineage commitment of adult hippocampal neuroprogenitors

Elmi, Muna; Matsumoto, Yoshiki; Zeng, Zhao-jun; Pavithra, Lakshminarasimhan; Yang, Weiwen; Nishikawa, Shin‐Ichi; Moshiri, Alicia; Tajima, Nobuyoshi; Ågren, Hans; Funa, Keiko

doi:10.1016/j.mcn.2010.06.003

Cited by 46 publications

(50 citation statements)

References 38 publications

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“…Recently, other functions of TLX have also been reported. TLX directly activates the Ascl1/ Mash1 promoter through interaction with Sp1, recruiting coactivators, but dismissing the co-repressor HDAC4 (39). It is suggested that TLX not only acts as a repressor of cell cycle and glial differentiation, but also activates neuronal lineage commitment in adult NSCs.…”

Section: Discussionmentioning

confidence: 99%

SRY-box-containing Gene 2 Regulation of Nuclear Receptor Tailless (Tlx) Transcription in Adult Neural Stem Cells

Shimozaki

Zhang

Suh³

et al. 2012

Journal of Biological Chemistry

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Background: Sox2 and TLX are essential for the self-renewal of adult neural stem cells (NSCs). Results: Sox2 positively regulates TLX expression and antagonizes the negative feedback system of TLX by a physical interaction between Sox2 and TLX. Conclusion: Sox2 and TLX form a molecular network regulating adult NSCs. Significance: This molecular network is a target to discover new ways regulate endogenous neurogenesis.

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Section: Discussionmentioning

confidence: 99%

SRY-box-containing Gene 2 Regulation of Nuclear Receptor Tailless (Tlx) Transcription in Adult Neural Stem Cells

Shimozaki

Zhang

Suh³

et al. 2012

Journal of Biological Chemistry

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“…These cells exhibit morphology typical of radial glia and divide slowly to produce intermediate progenitor cells (IPCs; also referred to as type-2 cells), a type of transit amplifying cell (Filippov et al, 2003;Holmes et al, 2004;Kempermann et al, 2004;Steiner et al, 2004;Englund et al, 2005). Undifferentiated IPCs (also referred to as type-2a and type-2b cells) express Mash1, Ngn2, and Tbr2 (Englund et al, 2005;Helms et al, 2005;Ozen et al, 2007;Elmi et al, 2010) and divide rapidly to produce neuronal committed IPCs (type-3) (Englund et al, 2005;Lie et al, 2005;Roybon et al, 2009;Bedogni et al, 2010). NeuroD1 expression marks the end of the transient amplifying progenitor phase.…”

Section: Methodsmentioning

confidence: 99%

Foxg1Has an Essential Role in Postnatal Development of the Dentate Gyrus

Tian

Gong²,

Yang³

et al. 2012

J. Neurosci.

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Foxg1, formerly BF-1, is expressed continuously in the postnatal and adult hippocampal dentate gyrus (DG). This transcription factor (TF) is thought to be involved in Rett syndrome, which is characterized by reduced hippocampus size, indicating its important role in hippocampal development. Due to the perinatal death of Foxg1 Ϫ/Ϫ mice, the function of Foxg1 in postnatal DG neurogenesis remains to be explored. Here, we describe the generation of a Foxg1 fl/fl mouse line. Foxg1 was conditionally ablated from the DG during prenatal and postnatal development by crossing this line with a Frizzled9-CreER TM line and inducing recombination with tamoxifen. In this study, we first show that disruption of Foxg1 results in the loss of the subgranular zone and a severely disrupted secondary radial glial scaffold, leading to the impaired migration of granule cells. Moreover, detailed analysis reveals that Foxg1 may be necessary for the maintenance of the DG progenitor pool and that the lack of Foxg1 promotes both gliogenesis and neurogenesis. We additionally show that Foxg1 may be required for the survival and maturation of postmitotic neurons and that Foxg1 may be involved in Reelin signaling in regulating postnatal DG development. Last, prenatal deletion of Foxg1 suggests that it is rarely involved in the migration of primordial granule cells. In summary, we report that Foxg1 is critical for DG formation, especially during early postnatal stage.

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“…In the mouse, multiple genes involved in the development of the CNS and visual system have been identified as Tlx targets, such as Gsh2, Pax2, Pten, p21, p57, S100b, Aqp4, Plce1, Wnt7a, microRNA-9, Bmp4, and GFAP [21,[32][33][34][35][36][37][45][46][47][48][49][50] (Table 1). Interestingly, Tlx may act as a transcriptional activator for the expression of sirt1, Wnt7a, Mash1, and Oct-3/4 based on in vitro luciferase assays and chromatin immunoprecipitation assays [16,21,[51][52][53]. A consensus Nr2e1 binding sequence within the promoter region of its target gene has been proposed to contain AAGTCA, which has been identified in the promoters of Wnt7a, GFAP, S100b, Oct3/ 4, p21, Pax2, Plce1, and Pten [21,32,34,45,46,53,54].…”

Section: Tlx Expression Its Targets and Related Signal Pathwaysmentioning

confidence: 99%

“…Zhang et al further showed that Tlx is indispensable for stem-cell proliferation in the adult mouse brain and for certain cognitive functions such as spatial learning [36]. A later study using cultured adult rat hippocampus-derived progenitors showed that Tlx not only inhibits glial differentiation but also promotes neuronal lineage commitment by activating expression of the pro-neural gene Mash1 in these adult progenitor cells [51]. Recently, Tlx has been shown to restrain senescence in NSCs and cancer cells [63,64].…”

Section: Roles Of Tlx Homologues In the Regulation Of Nscs And Brain mentioning

confidence: 99%

The Orphan Nuclear Receptor TLX/NR2E1 in Neural Stem Cells and Diseases

Wang

Xiong

2016

Neurosci. Bull.

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The human TLX gene encodes an orphan nuclear receptor predominantly expressed in the central nervous system. Tailess and Tlx, the TLX homologues in Drosophila and mouse, play essential roles in body-pattern formation and neurogenesis during early embryogenesis and perform crucial functions in maintaining stemness and controlling the differentiation of adult neural stem cells in the central nervous system, especially the visual system. Multiple target genes and signaling pathways are regulated by TLX and its homologues in specific tissues during various developmental stages. This review aims to summarize previous studies including many recent updates from different aspects concerning TLX and its homologues in Drosophila and mouse.

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TLX activates MASH1 for induction of neuronal lineage commitment of adult hippocampal neuroprogenitors

Cited by 46 publications

References 38 publications

SRY-box-containing Gene 2 Regulation of Nuclear Receptor Tailless (Tlx) Transcription in Adult Neural Stem Cells

SRY-box-containing Gene 2 Regulation of Nuclear Receptor Tailless (Tlx) Transcription in Adult Neural Stem Cells

Foxg1Has an Essential Role in Postnatal Development of the Dentate Gyrus

The Orphan Nuclear Receptor TLX/NR2E1 in Neural Stem Cells and Diseases

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