TLR9 signaling requires ligand-induced phosphorylation of two specific tyrosine residues by EGFR and Syk
Manoj Veleeparambil,
Chenyao Wang,
Patricia M Kessler
et al.
Abstract:Toll-like receptors (TLRs) are transmembrane proteins required for recognizing microbial components or cellular danger signals to activate intracellular signaling pathways leading to induction of anti-microbial and inflammatory genes. Inactive TLRs require ligand-induced activation to recruit adaptor proteins, e.g., MyD88, to trigger the synthesis of cytokines and interferons. TLR9 is an endosomal membrane-bound protein, which binds to CpG-containing microbial DNA or endogenous signals from dead cells or tissu… Show more
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