TLR8 is Activated by 5’-Methylthioinosine, a  &lt;i&gt;Plasmodium Falciparum-Specific&lt;/i&gt; Intermediate of the Purine Salvage Pathway

Köllisch, Gabriele; Solis, Francisco Venegas; Obermann, Hannah-Lena; Eckert, Jeannine; Müller, Thomas; Vierbuchen, Tim; Rickmeyer, Thomas; Muche, Simon; Heine, Holger; Kaufmann, Andreas M.; Baumeister, Stefan; Lingelbach, Klaus; Bauer, Stefan

doi:10.2139/ssrn.3651097

Cited by 1 publication

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“…TLR7 and TLR8 recognize plasmodium-derived RNA. [107] TLR8 has been associated with severe infected malaria in Mali children. [108] TLR9 (rs5743836) A > G appears to affect malaria progression and susceptibility in specific populations.…”

Section: Receptorsmentioning

confidence: 99%

Host Genetic Impact on Infectious Diseases among Different Ethnic Groups

Naidoo,

Arumugam,

Ramsuran

2023

Advanced Genetics

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Infectious diseases such as malaria, tuberculosis (TB), human immunodeficiency virus (HIV), and the coronavirus disease of 2019 (COVID‐19) are problematic globally, with high prevalence particularly in Africa, attributing to most of the death rates. There have been immense efforts toward developing effective preventative and therapeutic strategies for these pathogens globally, however, some remain uncured. Disease susceptibility and progression for malaria, TB, HIV, and COVID‐19 vary among individuals and are attributed to precautionary measures, environment, host, and pathogen genetics. While studying individuals with similar attributes, it is suggested that host genetics contributes to most of an individual's susceptibility to disease. Several host genes are identified to associate with these pathogens. Interestingly, many of these genes and polymorphisms are common across diseases. This paper analyzes genes and genetic variations within host genes associated with HIV, TB, malaria, and COVID‐19 among different ethnic groups. The differences in host–pathogen interaction among these groups, particularly of Caucasian and African descent, and which gene polymorphisms are prevalent in an African population that possesses protection or risk to disease are reviewed. The information in this review could potentially help develop personalized treatment that could effectively combat the high disease burden in Africa.

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Section: Receptorsmentioning

confidence: 99%