TLR7 Modulated T Cell Response in the Mesenteric Lymph Node of <i>Schistosoma japonicum</i>-Infected C57BL/6 Mice

Qu, Jiale; Yu, Xueying; Jin, Chenxi; Feng, Yuanfa; Xie, Shihao; Xie, Hongyan; Yang, Quan; Qi, Yanwei; Qiu, Huaina; Chen, Hong‐Yuan; Mu, Jianbing; Zhou, Yi; Huang, Jun

doi:10.1155/2019/2691808

Cited by 7 publications

(5 citation statements)

References 39 publications

(48 reference statements)

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“…The results indicated that the relative TLR7 mRNA level in hepatic lymphocytes from infected mice was lower than that in hepatic lymphocytes from naive mice. This might be induced by the amount of infection, recruiting lower TLR7expressing lymphocytes, such as T cells and B cells, as we observed in mesenteric lymph nodes (Qu et al, 2019). This hypertension was validated by the FCM results, which indicated that the percentage of TLR7-expressing cells was increased in the isolated hepatic lymphocytes.…”

Section: Discussionsupporting

confidence: 71%

Roles of TLR7 in Schistosoma japonicum Infection-Induced Hepatic Pathological Changes in C57BL/6 Mice

Feng

Xie

Shi

et al. 2021

Front. Cell. Infect. Microbiol.

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S. japonicum infection can induce granulomatous inflammation in the liver of the host. Granulomatous inflammation limits the spread of infection and plays a role in host protection. Toll-like receptor 7 (TLR7) is an endosomal TLR that recognizes single-stranded RNA (ssRNA). In this study, the role of TLR7 in S. japonicum infection-induced hepatitis was investigated in both normal and TLR7 knockout (KO) C57BL/6 mice. The results indicated that TLR7 KO could aggravate S. japonicum infection-induced damage in the body, with less granuloma formation in the tissue, lower WBCs in blood, and decreased ALT and AST in the serum. Then, the expression of TLR7 was detected in isolated hepatic lymphocytes. The results indicated that the percentage of TLR7+ cells was increased in the infected mice. Hepatic macrophages, DCs, and B cells could express TLR7, and most of the TLR7-expressing cells in the liver of infected mice were macrophages. The percentage of TLR7-expressing macrophages was also increased after infection. Moreover, macrophages, T cells, and B cells showed significant changes in the counts, activation-associated molecule expression, and cytokine secretion between S. japonicum-infected WT and TLR7 KO mice. Altogether, this study indicated that TLR7 could delay the progression of S. japonicum infection-induced hepatitis mainly through macrophages. DCs, B cells, and T cells were involved in the TLR7-mediated immune response.

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Section: Discussionsupporting

confidence: 71%

Roles of TLR7 in Schistosoma japonicum Infection-Induced Hepatic Pathological Changes in C57BL/6 Mice

Feng

Xie

Shi

et al. 2021

Front. Cell. Infect. Microbiol.

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“…SEA and SWA are major antigens to induce liquid immune response in S . japonicum infected mice [ 6 ]. To explore the roles of B cells in the spleens of S .…”

Section: Resultsmentioning

confidence: 99%

“…For example, our previous study found that the percentage of TLR7 expressed T lymphocytes from the mesenteric lymph node (MLN) of S . japonicum infected mice increased on week 6 post infection [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

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TLR7 modulating B-cell immune responses in the spleen of C57BL/6 mice infected with Schistosoma japonicum

Wei

Xie

et al. 2021

PLoS Negl Trop Dis

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B cells played an important role in Schistosoma infection-induced diseases. TLR7 is an intracellular member of the innate immune receptor. The role of TLR7 on B cells mediated immune response is still unclear. Here, C57BL/6 mice were percutaneously infected by S. japonicum for 5–6 weeks. The percentages and numbers of B cells increased in the infected mice (p < 0.05), and many activation and function associated molecules were also changed on B cells. More splenic cells of the infected mice expressed TLR7, and B cells were served as the main cell population. Moreover, a lower level of soluble egg antigen (SEA) specific antibody and less activation associated molecules were found on the surface of splenic B cells from S. japonicum infected TLR7 gene knockout (TLR7 KO) mice compared to infected wild type (WT) mice (p < 0.05). Additionally, SEA showed a little higher ability in inducing the activation of B cells from naive WT mice than TLR7 KO mice (p < 0.05). Finally, the effects of TLR7 on B cells are dependent on the activation of NF-κB p65. Altogether, TLR7 was found modulating the splenic B cell responses in S. japonicum infected C57BL/6 mice.

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“…Additionally, the expression of TLR7 is increased in the mesenteric lymph node CD4 + and CD8 + T cells after Schistosoma japonicum infection. The TLR7 agonist can enhance the production of IFN-γ in CD8 + T cells from mesenteric lymph node T cells in infected mice ( 141 ). Moreover, TLR7/MyD88-dependent signaling activation in CD8 + T cells can promote cellular glycolysis and enhance T cell effector functions ( 142 ).…”

Section: Tlr-mediated Regulation Of T Cellsmentioning

confidence: 99%

Toll-Like Receptor Signaling and Its Role in Cell-Mediated Immunity

et al. 2022

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Innate immunity is the first defense system against invading pathogens. Toll-like receptors (TLRs) are well-defined pattern recognition receptors responsible for pathogen recognition and induction of innate immune responses. Since their discovery, TLRs have revolutionized the field of immunology by filling the gap between the initial recognition of pathogens by innate immune cells and the activation of the adaptive immune response. TLRs critically link innate immunity to adaptive immunity by regulating the activation of antigen-presenting cells and key cytokines. Furthermore, recent studies also have shown that TLR signaling can directly regulate the T cell activation, growth, differentiation, development, and function under diverse physiological conditions. This review provides an overview of TLR signaling pathways and their regulators and discusses how TLR signaling, directly and indirectly, regulates cell-mediated immunity. In addition, we also discuss how TLR signaling is critically important in the host’s defense against infectious diseases, autoimmune diseases, and cancer.

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TLR7 Modulated T Cell Response in the Mesenteric Lymph Node of Schistosoma japonicum-Infected C57BL/6 Mice

Cited by 7 publications

References 39 publications

Roles of TLR7 in Schistosoma japonicum Infection-Induced Hepatic Pathological Changes in C57BL/6 Mice

Roles of TLR7 in Schistosoma japonicum Infection-Induced Hepatic Pathological Changes in C57BL/6 Mice

TLR7 modulating B-cell immune responses in the spleen of C57BL/6 mice infected with Schistosoma japonicum

Toll-Like Receptor Signaling and Its Role in Cell-Mediated Immunity

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