TLR4 single nucleotide polymorphisms and thrombosis risk in patients with myeloproliferative disorders

Speletas, Matthaios; Liadaki, Kyriaki; Kalala, Fani; Daiou, C; Katodritou, Eirini; Μανδαλά, Ευδοκία; Korantzis, Ioannis; Ritis, Konstantinos; Ζιντζαράς, Ηλίας; Germenis, Anastasios E.

doi:10.1016/j.thromres.2007.09.016

Cited by 2 publications

(1 citation statement)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two Toll-like receptor 4 (TLR4) SNPs (TLR4-D299G and TLR4-T399I) were being investigated by Speletas et al [164], who found no significant correlation between either of the SNPs and thrombosis risk (p = 0.43 and p = 0.99, respectively). TLR4-D299G polymorphism seems to exhibit a protective role in the thrombotic effect, but more studies are needed to confirm this finding.…”

Section: Gene Polymorphisms In Thrombotic Mpnmentioning

confidence: 99%

Molecular Genetics of Thrombotic Myeloproliferative Neoplasms: Implications in Precision Oncology

et al. 2023

View full text Add to dashboard Cite

Classical BCR-ABL-negative myeloproliferative neoplasms (MPN) include polycythaemia vera, essential thrombocythaemia, and primary myelofibrosis. Unlike monogenic disorders, a more complicated series of genetic mutations are believed to be responsible for MPN with various degrees of thromboembolic and bleeding complications. Thrombosis is one of the early manifestations in patients with MPN. To date, the driver genes responsible for MPN include JAK2, CALR, MPL, TET2, ASXL1, and MTHFR. Affords have been done to elucidate these mutations and the incidence of thromboembolic events. Several lines of evidence indicate that mutations in JAK2, MPL, TET2 and ASXL1 gene and polymorphisms in several clotting factors (GPIa, GPIIa, and GPIIIa) are associated with the occurrence and prevalence of thrombosis in MPN patients. Some polymorphisms within XRCC1, FBG, F2, F5, F7, F12, MMP9, HPA5, MTHFR, SDF-1, FAS, FASL, TERT, ACE, and TLR4 genes may also play a role in MPN manifestation. This review aims to provide an insightful overview on the genetic perspective of thrombotic complications in patients with MPN.

show abstract

Section: Gene Polymorphisms In Thrombotic Mpnmentioning

confidence: 99%