TLR4 single-nucleotide polymorphisms alter mucosal cytokine and chemokine patterns in Mexican patients with Helicobacter pylori-associated gastroduodenal diseases

O, Alejandra Trejo-de la; Torres, Javier; Pérez-Rodríguez, Martha; Camorlinga‐Ponce, Margarita; Luna, Landy; Abdo-Francis, José M.; Lazcano, Eduardo; Maldonado‐Bernal, Carmen

doi:10.1016/j.clim.2008.07.009

Cited by 69 publications

(64 citation statements)

References 41 publications

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“…Previously TLR4 ϩ896G carriers were shown to have an 11-fold (95% CI ϭ 2.5 to 48) increased OR of developing gastric cancer (18). The association of the TLR4 ϩ896G polymorphism and also the TLR4 ϩ1196T polymorphism with increased risk of gastric cancer have subsequently been assessed in several studies, although their prevalence is known to vary dramatically depending on the ethnic background (1,32,38,41).…”

Section: Discussionmentioning

confidence: 99%

Increase in NF-κB Binding Affinity of the Variant C Allele of the Toll-Like Receptor 9 −1237T/C Polymorphism Is Associated with Helicobacter pylori -Induced Gastric Disease

Hof

Crockett

et al. 2010

Infect Immun

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Colonization of the gastric mucosa by Helicobacter pylori can lead to serious clinical outcomes, including gastric cancer. Toll-like receptors (TLRs) play an important role in the host response to H. pylori through the recognition of pathogen-associated molecular patterns. TLR9, in particular, is partly responsible for initiating bacterial induced immunity by binding unmethylated CpG-DNA, which is abundant in bacteria. A welldocumented single nucleotide polymorphism (SNP) within the TLR9 promoter (TLR9 ؊1237T/C), is associated with a variety of inflammatory disorders, including allergic asthma, inflammatory bowel disease, and atopy. Analysis of the TLR9 promoter gene sequence has shown that carriage of the variant "C" allele at position ؊1237 creates a potential NF-B binding site that would theoretically increase the transcriptional activity of the gene. In this study, we report that the TLR9 ؊1237 C allele was significantly associated with the development of H. pylori-induced premalignant gastric changes. Functional analysis of the SNP, supporting the data generated from the genetic association study, showed that carriage of the C allele increased TLR9 transcriptional activity driven mainly by activation of NF-B. Collectively, these findings confirm that the TLR9 ؊1237T/C polymorphism is a risk factor for the development of H. pylori-induced premalignant gastric changes and provide a plausible mechanistic explanation.

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Section: Discussionmentioning

confidence: 99%

Increase in NF-κB Binding Affinity of the Variant C Allele of the Toll-Like Receptor 9 −1237T/C Polymorphism Is Associated with Helicobacter pylori -Induced Gastric Disease

Hof

Crockett

et al. 2010

Infect Immun

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“…Moreover, Asp299Gly and Thr399Ile polymorphisms have been reported to be associated with different diseases such as gastric cancer, hepatitis C virus-induced hepatocellular carcinoma, Crohn's Disease and ulcerative colitis [16,52,53], supporting a functional role for these polymorphisms. Also, these two polymorphisms seem to modify the pattern of inflammatory cytokines and chemokines in the gastric mucosa, suggesting a contribution to the clinical outcome of H. pylori infection [54].…”

Section: Citationmentioning

confidence: 99%

Association between Asp299Gly and Thr399Ile Polymorphisms in Toll-Like Receptor 4 Gene and Type 2 Diabetes Mellitus: Case-Control Study and Meta-Analysis

2014

J Diabetes Metab

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“…The presence of Asp299Gly was observed to be responsible for an increased risk of antrumpredominant gastritis, corpus-predominant gastritis and pangastritis, while that of Thr399Ile was found to be related only to corpus-predominant gastritis and pangastritis [81]. Asp299Gly was associated with increased risk of noncardia gastric carcinoma and duodenal ulcer but there was no such association for esophageal squamous cell carcinoma, adenocarcinoma, and gastric cardiac carcinoma [79,82]. Garza-Gonzalez et al [83] did not find an association between risk of distal gastric cancer and Thr399Ile and Asp299Gly, while Santini et al [84] reported an association of only the former with increased susceptibility of intestinal gastric cancer.…”

Section: Cancersmentioning

confidence: 99%

TLR4 polymorphisms and disease susceptibility

et al. 2012

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Toll-like receptors (TLRs) play a central role in the regulation of the host immune system. Each TLR recognizes specific pathogen-associated molecular patterns (PAMPs). TLR4 is one of the well characterized pathogen recognition receptors (PRRs) that recognizes the lipopolysaccharide (LPS) of Gram-negative bacteria, some conserved structures from fungal to mycobacterial pathogens and some endogenous ligands. A complex signaling cascade initiates after the ligand binds to the TLR4 ectodomain, leading to the activation of multiple inflammatory genes. Genetic variations greatly influence immune responses towards pathogenic challenges and disease outcome. In this review, we summarize various reports regarding TLR4 polymorphisms and disease susceptibility.

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TLR4 single-nucleotide polymorphisms alter mucosal cytokine and chemokine patterns in Mexican patients with Helicobacter pylori-associated gastroduodenal diseases

Cited by 69 publications

References 41 publications

Increase in NF-κB Binding Affinity of the Variant C Allele of the Toll-Like Receptor 9 −1237T/C Polymorphism Is Associated with Helicobacter pylori -Induced Gastric Disease

Increase in NF-κB Binding Affinity of the Variant C Allele of the Toll-Like Receptor 9 −1237T/C Polymorphism Is Associated with Helicobacter pylori -Induced Gastric Disease

Association between Asp299Gly and Thr399Ile Polymorphisms in Toll-Like Receptor 4 Gene and Type 2 Diabetes Mellitus: Case-Control Study and Meta-Analysis

TLR4 polymorphisms and disease susceptibility

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