TLR2–TLR4/CD14 polymorphisms and predisposition to severe invasive infections by Neisseria meningitidis and Streptococcus pneumoniae

Orriols, Juan José Tellería; García-Salido, Alberto; Varillas‐Delgado, David; Serrano-González, Ana; Casado‐Flores, Juan

doi:10.1016/j.medin.2013.08.006

Cited by 18 publications

(20 citation statements)

References 36 publications

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“…The characteristics of included studies are summarized in Table 1. Apart from studies not providing sufficient information for χ 2 test, genotype distributions in controls were consistent with HWE in all studies for the polymorphism rs4986791 ( P > 0.05, with a range of 0.3620 to 0.8560); while such distributions deviated from HWE expectation in two studies from the report by Tellería-Orriols et al 20. for the polymorphism rs4986790 ( P = 0.0001), and perfectly fit in with the expectation in the other studies with P values ranging from 0.1690 to 0.9620.…”

Section: Resultsmentioning

confidence: 50%

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The relationship between toll like receptor 4 gene rs4986790 and rs4986791 polymorphisms and sepsis susceptibility: A meta-analysis

Wang

et al. 2016

Sci Rep

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Accumulating evidences have demonstrated that lipopolysaccharide (LPS) represents the important etiologic factor for sepsis. Some previous studies have reported the relationship between common polymorphisms rs4986790 and rs4986791 in the coding gene for this receptor and the susceptibility to sepsis, but there were distinct divergences between those findings. We therefore designed this meta-analysis incorporated 28 published articles containing 6,537 sepsis patients and 8,832 controls for a more comprehensive conclusion on this matter. Odds ratios (ORs) and 95% confidence interval (95% CIs) were calculated to evaluate the association of toll like receptor 4 gene polymorphisms rs4986790 and rs4986791 with sepsis risk. Heterogeneity between included studies was inspected using Q test, and sensitivity analysis was implemented via sequential deletion of each included study to investigate the stability of overall estimates. Funnel plot and Egger’s test were adopted to examine publication bias across selected studies. We found no significant association for either the polymorphism rs4986790 or rs4986791 with sepsis susceptibility in total analysis under any genetic models. Neither did we after combining these two polymorphisms. The results of this meta-analysis suggest that the rs4986790 and rs4986791 polymorphisms in toll like receptor 4 gene may have no statistically significant influence on sepsis susceptibility.

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Section: Resultsmentioning

confidence: 50%

“…Therefore, as showed in Fig. 1, this meta-analysis finally included 28 eligible articles, containing 51 independent case-control studies (31 for the polymorphism rs4986790 and 20 for rs4986791)13141617181920212223242526272829303132333435363738394041. The characteristics of included studies are summarized in Table 1.…”

Section: Resultsmentioning

confidence: 99%

The relationship between toll like receptor 4 gene rs4986790 and rs4986791 polymorphisms and sepsis susceptibility: A meta-analysis

Wang

et al. 2016

Sci Rep

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“…Statistically significant differences in TLR2 and TLR4 SNP frequency were found by Telleria-Orriols [31]. In the study group, there were 59 children with meningococcal infection (18 with meningococcal meningitis) and 114 with pneumococcal infection (only 12 with meningitis) of Caucasian origin.…”

Section: Tlr 2 and Tlr4mentioning

confidence: 96%

“…In the control group, the risk allele was found in 16.6% children ( p < 0.0001). This study showed two times higher frequency of TLR4 polymorphic variant in patients than in controls (23.7% vs 9.1%; p = 0.0472) [31]. …”

Section: Tlr 2 and Tlr4mentioning

confidence: 99%

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Genes and their single nucleotide polymorphism involved in innate immune response in central nervous system in bacterial meningitis: review of literature data

Gowin

Januszkiewicz‐Lewandowska

2018

Inflamm. Res.

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BackgroundThere are many studies analysing the effect of SNPs in genes coding proteins which are involved in innate immune response on susceptibility to invasive bacterial disease. Many of them gave inconclusive results. Regarding the complexity of immune response and cooperation between particular elements, number of SNPs may have a cumulative effect on the susceptibility to bacterial meningitis.FindingsIn most studies cooccurrence of several SNPs was not analysed. These studies were performed on small groups of patients and usually only few SNPs were checked simultaneously. Additionally, comparison of the results across the studies is hard to conduct. We hypothesise that the number of variants of genes involved in innate immune response plays a role in susceptibility to bacterial meningitis. However, the role of toll-like receptors and other part of innate immune response in the eradication of bacteria, and initiation of the inflammatory response in CNS need further studies.ConclusionLarge multicentre studies assessing multiple SNPs in patients with microbiologically proven pneumococcal or meningococcal meningitis are needed to find real genetic risk factors for developing bacterial meningitis. This is necessary to design more effective treatment and prevention strategies for severe infections.

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Toll-Like Receptor 4 Interactions with Neisseria

Christodoulides

2020

The Role of Toll-Like Receptor 4 in Infectious and Non Infectious Inflammation

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TLR2–TLR4/CD14 polymorphisms and predisposition to severe invasive infections by Neisseria meningitidis and Streptococcus pneumoniae

Cited by 18 publications

References 36 publications

The relationship between toll like receptor 4 gene rs4986790 and rs4986791 polymorphisms and sepsis susceptibility: A meta-analysis

The relationship between toll like receptor 4 gene rs4986790 and rs4986791 polymorphisms and sepsis susceptibility: A meta-analysis

Genes and their single nucleotide polymorphism involved in innate immune response in central nervous system in bacterial meningitis: review of literature data

Toll-Like Receptor 4 Interactions with Neisseria

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