TLR2 polymorphisms, Arg753Gln and Arg677Trp, are not associated with increased burden of tuberculosis in Indian patients

Abstract

Background: In view of the role of TLR2 activation in host defense against mycobacteria, the present study was conducted to examine whether TLR2 polymorphisms could account for the increased prevalence of tuberculosis in Indian patients. Detection of such polymorphisms would help in assessing the risk of developing active tuberculosis among contacts or HIV positive patients and in identifying candidates for chemoprophylaxis.

Susceptibility to SLE in South Indian Tamils may be influenced by genetic selection pressure on TLR2 and TLR9 genes

“…Our finding is in tandem with the earlier reports from southern and western part of India (Biswas et al, 2009;Arpita and Amita, 2013). A multiethnic cohort comprising of Chinese, Malaysian and Indians were screened for the presence of TLR2+2408 G/C polymorphism to study its association with the development of colorectal carcinoma.…”

Toll-like receptors, tumor necrosis factor–α, and interleukin-10 gene polymorphisms in risk of pulmonary tuberculosis and disease severity

“…This SNP had not been tested for an association with tuberculosis in previous studies; thus further research involving different ethnic populations might be warranted for comparison. The 2258 A/G of TLR2 gene was suggested to be associated with TB susceptibility in a Turkish population but was not found to be responsible for the increased prevalence of TB in the Indian population [28,41]. Here we detected no polymorphism in a Chinese Han population in our study, which obviously reflected a different genetic background.…”

Different Patterns of Toll-Like Receptor 2 Polymorphisms in Populations of Various Ethnic and Geographic Origins

“…This may also explain the discrepancy between those two studies and the absence of a correlation between this polymorphism and leprosy in patients from India (33) and Japan (34). We failed to find this polymorphism in populations from China or Trio Indians (who arrived in America via North-East Asia), findings supported by previous studies in China (12,60), South Korea (45,62), and India (7). Similarly, we also did not find this polymorphism in the Dogon and Fulani populations from Mali, Africa, and others have failed to find it in populations from Ethiopia (8).…”