1974
DOI: 10.1111/j.1748-1716.1974.tb05681.x
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Titratable Acid, Pco2, Bicarbonate and Ammonium Ions along the Rat Proximal Tubule

Abstract: KARLMARK, B. and B. G. DANIELSON. Titratable acid, Pcoz, bicarbonate and ammonium ions along the rat proximal tubule. Acta physiol. scand. 1974. 91. 243 -258.

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Cited by 34 publications
(18 citation statements)
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References 44 publications
(22 reference statements)
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“…The finding of an elevated Pco2 throughout the renal cortex, although somewhat surprising initially, is quite compatible with previously reported values for in situ pH (2,3,9) and bicarbonate concentration (9,12,18). In fact, if one assumes reaction equilibrium in the proximal tubule, a pH of 6.71, and a bicarbonate concentration of 8 mM, the calculated Pco2 for these values would be 65 mm Hg.…”
Section: Discussionsupporting
confidence: 77%
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“…The finding of an elevated Pco2 throughout the renal cortex, although somewhat surprising initially, is quite compatible with previously reported values for in situ pH (2,3,9) and bicarbonate concentration (9,12,18). In fact, if one assumes reaction equilibrium in the proximal tubule, a pH of 6.71, and a bicarbonate concentration of 8 mM, the calculated Pco2 for these values would be 65 mm Hg.…”
Section: Discussionsupporting
confidence: 77%
“…In contrast, our electrode has the following characteristics: sensitivity of 57-61 mV/log10 Pco2 (near theoretic or Nernstian response), stability ofintercept, a tip diameter sufficiently small to allow direct measurement in all segments of the nephron, and does not exhibit sensitivity to 02 or N2. The present study, therefore, circumvents the disadvantages inherent in the indirect and direct methodology employed in the studies cited above (12,13). Repeated determinations (68 proximal tubules) in 21 control rats clearly establish that proximal tubular Pco2 exceeds arterial Pco2 under normal acid-base conditions (Table II).…”
Section: Discussionmentioning
confidence: 86%
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“…While the biochemical events involved in the renal production of ammonia seem clear (1,2), the secretory site(s) in the nephron are less well defined. Micropuncture studies in rats (3)(4)(5)(6)(7) reported that the concentration of ammonium in fluid obtained along the proximal segments of surface nephrons was higher than could be accounted for by water extraction suggesting that ammonium entry occurs in this segment of the renal tubule. Further, these studies reported a higher concentration of this buffer in tubular fluid when rats were J. Clin.…”
Section: Introductionmentioning
confidence: 99%