Title: Sublingual glyceryl trinitrate vasoreactivity testing during right heart catheterization for the diagnosis of pulmonary hypertension related to left heart disease

Prognostic Power of Pulmonary Arterial Compliance Is Boosted by a Hemodynamic Unloading Test With Glyceryl Trinitrate in Heart Failure Patients With Post-capillary Pulmonary Hypertension

“…Beyond this scenario, information gained from an acute vasodilator challenge is of uncertain clinical significance, possibly owing to the heterogeneity of vasodilators used for testing in LHF patients, missing standard protocol and the lack of studies on prognostic implications ( 11 ). Despite these facts, VRT is part of the standard hemodynamic workup of patients with LHF in several heart failure centres; according to local customs, sublingual glyceryl trinitrate (GTN) may be used as vasodilator ( 12 ). GTN as an arterial and venous vasodilator may be advantageous in LHF patients compared with selective pulmonary vasodilators such as inhaled nitric oxide or iloprost, because the latter may lead to an increase of left ventricular filling pressures and pulmonary edema ( 11 ).…”