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Benedek, Ladislaus; Porsche, Franz Oskar

doi:10.1159/000396345

Cited by 3 publications

(3 citation statements)

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“…It is enzymatically reduced to show red color in normal tissues, but it remains white color in an area of necrotic tissues. 40 The normal brain tissues showed red, but the I/R injured brain showed pale color, indicating that MCAO damaged brain tissues. When mice were treated with RvD2-HVs, the brain tissues (left side of the image) injured due to MCAO showed red similar as that of sham mice.…”

Section: Rvd2-loaded Nanovesicles Protect Brain Injury Induced By Strokementioning

confidence: 96%

Neutrophil Membrane-Derived Nanovesicles Alleviate Inflammation To Protect Mouse Brain Injury from Ischemic Stroke

et al. 2019

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Ischemic stroke is an acute and severe neurological disease, resulting in the disability and death. Reperfusion to an ischemic brain is a means to reverse brain damage after stroke; however, this causes secondary tissue damage induced by inflammation responses, called ischemia/reperfusion (I/R) injury. Adhesion of neutrophils to endothelial cells underlies the initiation of inflammation in I/R. Inspired by this interaction, we report a drug delivery system comprised of neutrophil membrane-derived nanovesicles loaded with Resolvin D2 (RvD2) that can enhance resolution of inflammation, thus protecting brain damage during ischemic stroke. In the study, the middle cerebral artery occlusion (MCAO) mouse model was developed to mimic ischemic stroke. Using intravital microscopy of live mouse brain, we real time visualized the binding of nanovesicles to inflamed brain vasculature for delivery of therapeutics to ischemic stroke lesions. We also observed that RvD2-loaded nanovesicles dramatically decreased inflammation in ischemic stroke and improved mouse neurological functions. Our study provides a strategy to inhibit neuroinflammation using neutrophil-derived nanovesicles for ischemic stroke therapy.

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Section: Rvd2-loaded Nanovesicles Protect Brain Injury Induced By Strokementioning

confidence: 96%

Neutrophil Membrane-Derived Nanovesicles Alleviate Inflammation To Protect Mouse Brain Injury from Ischemic Stroke

et al. 2019

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“…[38] DNP basis set used for our calculations is comparable to Gaussian 6-31G**, but DNP is more accurate than a Gaussian basis set of the same size. [39,40] For the vibrational frequency calculations, same level of theory was used. We have obtained stable minima which correspond to the real and positive values and the first order saddle points (transition states) are characterized by imaginary frequency.…”

Section: Experimental Section General Informationmentioning

confidence: 99%

An Insight into Nitromethane as an Organic Nitrile Alternative Source towards the Synthesis of Aryl Nitriles

et al. 2019

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Directed by an unusual in situ reduction of CuII, our protocol is a simple CuI‐mediated synthesis of aryl nitriles, with inexpensive and readily available nitromethane as the cyanating source, in moderate to good yields. Exhibiting a wide substrate scope, the method involves simple reaction conditions, is additive free with low catalyst loading. The plausible mechanism of cyanation of aryl halides is elucidated by a congregation of three cycles, namely the in situ reduction of CuII species by nitromethane, generation of HCN species from nitromethane and a regular organometallic pathway which releases the nitrile derivative. The detail of the mechanism of generation of CN– from nitromethane is computationally validated. Our protocol holds the distinction of involving a rarely encountered CuI catalytic species as well as facile in situ generation of nucleophilic CN– to yield synthetically useful aromatic nitriles.

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“…DNP numerical basis set is used as it is the highest quality basis set available in DMol 3 . [52] It is to be noted that although the size of DNP basis set is comparable with the 6-31G(d,p) basis set and DNP is usually more accurate than a Gaussian basis set of the same size. [52][53] Finally, the electron injection mechanism between the dye and the TiO 2 surface was investigated using TD-CAMÀB3LYP/6-31G(d,p) level, in vacuum, at ground state DMol 3 optimized geometry.…”

Section: Computational Detailsmentioning

confidence: 99%

Computational Investigation of the Influence of π‐Bridge Conjugation Order of Thiophene and Thiazole Units in Triphenylamine Based Dyes in Dye‐Sensitized Solar Cells

et al. 2018

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In this study, ten triphenylamine based dyes were investigated by varying the π‐bridge size with a different order of thiophene and thiazole units to understand their potential use in dye‐sensitized solar cells (DSSCs). Geometry optimization, the energy levels and electron density of the highest occupied molecular orbital and the lowest unoccupied molecular orbital, and UV‐visible absorption spectra were calculated using density functional theory (DFT) and time‐dependent DFT (TD‐DFT) methods. The electron injection driving force, dye regeneration driving force, natural bond orbital (NBO) analysis of dye‐(TiO2)8 cluster and dye reorganization energy were calculated to predict the most suitable dyes for DSSC application. Dye 4 ((Z)‐2‐cyano‐3‐(2′‐((E)‐4‐(diphenylamino)styryl)‐[2, 5′‐bithiazol]‐4‐yl)acrylic acid) followed by Dye 6 ((Z)‐2‐cyano‐3‐(5‐(2‐((E)‐4‐(diphenylamino)styryl)thiazol‐5‐yl)thiophen‐3‐yl)acrylic acid) having two linker moieties were identified as the potential candidates.

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Title Page

Cited by 3 publications

References 0 publications

Neutrophil Membrane-Derived Nanovesicles Alleviate Inflammation To Protect Mouse Brain Injury from Ischemic Stroke

Neutrophil Membrane-Derived Nanovesicles Alleviate Inflammation To Protect Mouse Brain Injury from Ischemic Stroke

An Insight into Nitromethane as an Organic Nitrile Alternative Source towards the Synthesis of Aryl Nitriles

Computational Investigation of the Influence of π‐Bridge Conjugation Order of Thiophene and Thiazole Units in Triphenylamine Based Dyes in Dye‐Sensitized Solar Cells

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