Titanoxidkeramik als Implantationsmaterial in der Ohrchirurgie: Tierexperimentelle Ergebnisse zur Operationstechnik

Stieve, Martin; Schwab, Burkard; Winter, Matthias; Lenarz, T

doi:10.1055/s-2006-925219

Cited by 6 publications

(1 citation statement)

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“…Their advantage is the size of the middle ear which makes an implantation of real ossicular replacement prostheses possible. Additionally, the rabbit model offers the chance of functional studies [17,25,26]. Unfortunately, their genome is not completely known so far which makes a genetic evaluation impossible.…”

Section: Animal Modelmentioning

confidence: 99%

Free Bioverit ^® II Implants Coated with a Nanoporous Silica Layer in a Mouse Ear Model — A Histological Study

et al. 2008

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The objective of this study is to evaluate the suitability of a mouse middle ear model for testing ossicular replacement materials. Twenty-four BALB/c mice are implanted with the bioglass-ceramic Bioverit Õ II which is coated with a silica-nanostructure or with plain Bioverit Õ II as a control. After 2, 6, and 12 weeks, 4 mice per group are sacrificed and both complete petrous bones are analyzed histologically. All implants revealed in situ an incipient growth of thin connective tissue layers over the surface, followed by a *Author to whom correspondence should be addressed. E-mail: Brandes.gudrun@mh-hannover.de spreading of epithelial cells. The osseogenic response which is increasing with time is more intense in the coated Bioverit Õ II specimens. The absence of inflammatory cells suggests an excellent biocompatibility of the silica nano structure. As the results are comparable to a study with the same materials in rabbits, the mouse model described is highly suitable for evaluation of new ossicular replacement materials. Additionally, by gene expression analysis a more detailed insight into cellular interactions of the middle ear is offered.

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Section: Animal Modelmentioning

confidence: 99%

Free Bioverit ^® II Implants Coated with a Nanoporous Silica Layer in a Mouse Ear Model — A Histological Study

et al. 2008

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Implantate im Mittelohrbereich — Teil 2 (Ergänzungen 2007)

Stieve¹,

Lenarz²

Medizintechnik Life Science Engineering

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Implantate im Mittelohrbereich – Teil 2 (Ergänzungen 2007)

Stieve¹,

Lenarz

2009

Medizintechnik

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Titanoxidkeramik als Implantationsmaterial in der Ohrchirurgie: Tierexperimentelle Ergebnisse zur Operationstechnik

Abstract: The laser surgery is a very safe procedure for prosthesis implantation in the middle ear of rabbits..

Cited by 6 publications

References 20 publications

Free Bioverit ^® II Implants Coated with a Nanoporous Silica Layer in a Mouse Ear Model — A Histological Study

Free Bioverit ^® II Implants Coated with a Nanoporous Silica Layer in a Mouse Ear Model — A Histological Study

Implantate im Mittelohrbereich — Teil 2 (Ergänzungen 2007)

Implantate im Mittelohrbereich – Teil 2 (Ergänzungen 2007)

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Titanoxidkeramik als Implantationsmaterial in der Ohrchirurgie: Tierexperimentelle Ergebnisse zur Operationstechnik

Abstract: The laser surgery is a very safe procedure for prosthesis implantation in the middle ear of rabbits..

Cited by 6 publications

References 20 publications

Free Bioverit ® II Implants Coated with a Nanoporous Silica Layer in a Mouse Ear Model — A Histological Study

Free Bioverit ® II Implants Coated with a Nanoporous Silica Layer in a Mouse Ear Model — A Histological Study

Implantate im Mittelohrbereich — Teil 2 (Ergänzungen 2007)

Implantate im Mittelohrbereich – Teil 2 (Ergänzungen 2007)

Contact Info

Product

Resources

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Free Bioverit ^® II Implants Coated with a Nanoporous Silica Layer in a Mouse Ear Model — A Histological Study

Free Bioverit ^® II Implants Coated with a Nanoporous Silica Layer in a Mouse Ear Model — A Histological Study