Titanium oxide thin films obtained with physical and chemical vapour deposition methods for optical biosensing purposes

Dominik, Magdalena; Leśniewski, Adam; Janczuk, Marta; Niedziółka‐Jönsson, Joanna; Hołdyński, Marcin; Wachnicki, Ł.; Godlewski, M.; Bock, Wojtek J.; Śmietana, Mateusz

doi:10.1016/j.bios.2016.09.079

Cited by 43 publications

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References 33 publications

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“…Structural, optical, and mechanical properties of TiO 2 nanolaminates 1. Introduction Titanium dioxide (TiO 2 ) thin films have extensively been investigated as non-toxic, chemically stable, low-cost semiconducting coatings in a wide area of applications such as solar cells [1], photocatalysis [2], batteries [3], wire grid polarizers [4], sensors [5], etc. TiO 2 is considered to be a promising candidate among dielectrics as high refractive index optical coating in multilayer optical systems [6,7].…”

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confidence: 99%

Structural, optical, and mechanical properties of TiO₂ nanolaminates

et al. 2020

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The structural, optical, and mechanical properties of TiO 2 nanolaminate films grown by plasmaenhanced atomic layer deposition are discussed. Several TiO 2 /Al 2 O 3 and TiO 2 /SiO 2 compositions have been investigated to study the effect of the relative number of ALD oxide cycles on the film properties to obtain a high refractive index coating with low optical losses, low roughness, and low mechanical stress. The formation of crystalline TiO 2 observed at high deposition temperature, or film thickness was inhibited by periodically introducing ultra-thin amorphous layers into the film. Only 4 ALD cycles of Al 2 O 3 (corresponding to ca. 0.5 nm) between 335 ALD cycles of TiO 2 (ca. 11 nm) form a closed, distinct layer suppressing the crystallization in TiO 2 film. Consequently, the roughness of the pure TiO 2 film is reduced from ca. 20 nm rms to 1 nm rms in the 335/4 nanolaminate, with only a slight decrease of the refractive index from 2.46 to 2.44 in 100 nm pure TiO 2 and the nanolaminate, respectively. The refractive indices of the nanolaminates in various compositions vary between 2.38 and 2.50 at 632 nm, and the corresponding optical losses from the films are low. The mechanical stress was reduced to about 140 MPa in several TiO 2 /Al 2 O 3 nanolaminates; however, lower mechanical stress has not been obtained with the studied compositions. The nanolaminate structure is preserved up to 600°C annealing temperature. After annealing at 800°C, the individual layers interdiffuse into each other so that no distinct nanolaminate structure is detected. By using TiO 2 /Al 2 O 3 nanolaminates with reduced mechanical stress, a narrow bandpass filter was realized on various substrates, including half-ball and aspherical lenses.

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Structural, optical, and mechanical properties of TiO₂ nanolaminates

et al. 2020

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“…Future work should focus on the measurements of norovirus samples to confirm the applicability of our sensor design for norovirus infection diagnostics. Additionally, the repeatability and sensitivity of the LPFG sensor may be improved by tuning the dispersion turning point and applying a high-refractive-index coating such as TiO x [34] or TaO x [35].…”

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confidence: 99%

Immunosensor Based on Long-Period Fiber Gratings for Detection of Viruses Causing Gastroenteritis

Janczuk-Richter

Gromadzka

Richter

et al. 2020

Sensors

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Since the norovirus is the main cause of acute gastroenteritis all over the world, its fast detection is crucial in medical diagnostics. In this work, a rapid, sensitive, and selective optical fiber biosensor for the detection of norovirus virus-like particles (VLPs) is reported. The sensor is based on highly sensitive long-period fiber gratings (LPFGs) coated with antibodies against the main coat protein of the norovirus. Several modification methods were verified to obtain reliable immobilization of protein receptors on the LPFG surface. We were able to detect 1 ng/mL norovirus VLPs in a 40-min assay in a label-free manner. Thanks to the application of an optical fiber as the sensor, there is a possibility to increase the user’s safety by separating the measurement point from the signal processing setup. Moreover, our sensor is small and light, and the proposed assay is straightforward. The designed LPFG-based biosensor could be applied in both fast norovirus detection and in vaccine testing.

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“…In addition, the nanomembrane can efficiently reduce the dissolution of active materials [83]. In the biosensorrelated field, maintaining the characteristic stability of biologic active molecule such as enzyme, antibody, biotin, and certain proteins is especially critical [84,85,86]. The protective shell formed by the ALD technique has become a promising strategy.…”

Section: Formation Of the Protective Layermentioning

confidence: 99%

“…The sensitivity of the biosensor was tested to be in the range from 1 pg/mL to 10 ng/mL of protein. Dominik et al [85] deposited titanium oxide thin films on a long-period grating (LPG) induced in an optical fiber for the recognition of the complex formation between biotin and avidin. The sensitivity of the sensor was close to 3400 nm/RIU for LPG.…”

Section: Applications Of Ald In Biosensorsmentioning

confidence: 99%

Atomic layer–deposited nanostructures and their applications in energy storage and sensing

et al. 2019

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Titanium oxide thin films obtained with physical and chemical vapour deposition methods for optical biosensing purposes

Cited by 43 publications

References 33 publications

Structural, optical, and mechanical properties of TiO₂ nanolaminates

Structural, optical, and mechanical properties of TiO₂ nanolaminates

Immunosensor Based on Long-Period Fiber Gratings for Detection of Viruses Causing Gastroenteritis

Atomic layer–deposited nanostructures and their applications in energy storage and sensing

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Titanium oxide thin films obtained with physical and chemical vapour deposition methods for optical biosensing purposes

Cited by 43 publications

References 33 publications

Structural, optical, and mechanical properties of TiO2 nanolaminates

Structural, optical, and mechanical properties of TiO2 nanolaminates

Immunosensor Based on Long-Period Fiber Gratings for Detection of Viruses Causing Gastroenteritis

Atomic layer–deposited nanostructures and their applications in energy storage and sensing

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Structural, optical, and mechanical properties of TiO₂ nanolaminates

Structural, optical, and mechanical properties of TiO₂ nanolaminates