Titanium modified with layer-by-layer sol–gel tantalum oxide and an organodiphosphonic acid: A coating for hydroxyapatite growth

Arnould, Christelle; Volcke, Cédric; Lamarque, Céline; Thiry, P.A.; Delhalle, Joseph; Mekhalif, Zineb

doi:10.1016/j.jcis.2009.03.092

Cited by 48 publications

(30 citation statements)

References 32 publications

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“…In order to optimize its biological properties in vivo , many methods have been used to modify the surface characteristics of tantalum metal, including acid pickling with HF/HNO 3 or HC1/H 2 SO 4 [20], biomimetic coatings [21, 22], the sol–gel method [23-25], anodic oxidation, alkaline–heat treatment, tantalum pentoxide (Ta 2 O 5 ) nanotube decoration [26], layer-by-layer depositions [24], and surface functionalization [25, 26]. However, to our knowledge, no studies of surface modification of allogenic cortical bone have been reported.…”

Section: Discussionmentioning

confidence: 99%

Surface Properties and MC3T3-E1 Cell Response of Cortical Bone Allografts Modified with Low-Concentration Phosphoric Acid

Huang

Cheng

Wang

et al. 2017

Cell Physiol Biochem

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Background/Aims: This experimental study aimed to evaluate the effect of low-concentration phosphoric acid on the surface structure of cortical allografts. Methods: Allogenic cortical bones were obtained from femurs and tibias of New Zealand white rabbits. The bones were modified by treatment with various concentrations of phosphoric acid (10%, 20% or 30%) for 10, 30 or 60 minutes, then evaluated by the following methods: 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) and LIVE/DEAD assay, alkaline phosphatase (ALP) assay, biomechanical properties testing, contact angle detection, quantitative real-time polymerase chain reaction (Q-PCR), western blotting and scanning electron microscopy (SEM). Results: Compared with the other groups, the group modified with 10% H₃PO₄ for 10 minutes had lower cytotoxicity according to MTT and LIVE/DEAD assays, higher hydrophilicity in the contact angle detection test and greater stability in the biomechanical properties test. Moreover, an up-regulation of osteopontin (OPN) in bones modified with 10% H₃PO₄ was observed by Q-PCR and western blotting. In addition, ALP assay and SEM showed that surface porosity and osteoinductivity were increased in the group modified with 10% H₃PO₄. Conclusions: Low-concentration phosphoric acid may be a potential method for surface modification of cortical allografts. Further animal experiments and animal infection model studies are required to validate the efficacy of surface-modified cortical allografts to repair large segmental bone defects.

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Section: Discussionmentioning

confidence: 99%

Surface Properties and MC3T3-E1 Cell Response of Cortical Bone Allografts Modified with Low-Concentration Phosphoric Acid

Huang

Cheng

Wang

et al. 2017

Cell Physiol Biochem

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“…The second approach was based on the adsorption of alkyl diphosphonic acids with the main inconvenience of grafting to the surface via the two ends of the molecules. This leads to low concentration of free phosphonic acids groups [22], which is similar to the case of the in situ modification of double bond terminal function [26]. The third approach was the use of molecules with multifunctional phosphonic acid groups (Scheme 1) which have revealed a promising potential in particular on the hydroxyapatite growth [17].…”

Section: Introductionmentioning

confidence: 91%

“…Our goal and approach is to keep the advantages of bulk physical characteristics of titanium and to change surface properties by the deposition of a thin tantalum oxide layer [17,[19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies indicate that COOH, PO 4 H 2 , SO 3 H and PO 3 H 2 groups are appropriate groups for calcium phosphate nucleation [5,6,12,13,25,27,28]. As organophosphonic groups are known to bind strongly to metal oxides [17,22,26,[29][30][31][32] like aluminium, titanium, tantalum oxides, grafting molecules containing numerous phosphonic groups (Scheme 1) could lead to a strong anchorage of HAp to the oxide surface [17,27]. Different strategies are investigated by our group in this area for the elaboration of bilayers essentially on titanium sheet but could be extended to other biocompatible materials such as nitinol, phynox (CoACr alloy) or steel.…”

Section: Introductionmentioning

confidence: 99%

“…Different strategies are investigated by our group in this area for the elaboration of bilayers essentially on titanium sheet but could be extended to other biocompatible materials such as nitinol, phynox (CoACr alloy) or steel. The first layer of the bilayers system is based on tantalum oxide formed by the layer-by-layer (LBL) solgel synthesis [22] or oxidised tantalum elaborated by electrodeposition in ionic liquid [17,33,34]. While the LBL approach has been reported as an easy process, it was shown to be time consuming and leading to very thin and less adherent tantalum oxide films.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Bilayers coating on titanium surface: The impact on the hydroxyapatite initiation

Arnould

Denayer

Planckaert

et al. 2010

Journal of Colloid and Interface Science

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Interaction of Plasma Deposited HMDSO-Based Coatings with Fibrinogen and Human Blood Plasma: The Correlation between Bulk Plasma, Surface Characteristics and Biomolecule Interaction

Gandhiraman

Muniyappa

Dudek

et al. 2010

Plasma Processes Polym.

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y These authors contributed equally.The success of a biomaterial depends on the nature of interaction and the progressive reaction between the biological components and the surface of the biomaterial. In order to control the interaction between the biomaterial and biological component, it is necessary to understand the factors that influence the protein adsorption and cell proliferation. Surface chemistry plays a crucial role in the success of any blood contacting biomaterial. Plasma enhanced chemical vapour deposition (PECVD) is an interesting commonly used technique for tailoring surface characteristics while retaining bulk material properties. Two different films, namely polymer-like and silica-like coatings, with varying surface characteristics have been deposited from hexamethyldisiloxane, by PECVD, on 316L stainless steel. A correlation between the bulk plasma, interfacial adhesion of the coating to 316L steel, surface characteristics and biomolecule interaction is presented in this work. The interfacial adhesion strength analysis demonstrated that silica-like coatings have higher adhesion strength to 316L stainless steel than polymer-like coatings, caused due to the formation of a strong FeÀOÀSi and ÀCrÀOÀSi bonds. It was observed that the effect of nanoscale surface roughness (close to 6 nm) was less significant, and that the surface chemistry played a significant role in governing the fibrinogen adsorption. Highest fibrinogen adsorption on plain steel was due to the electrostatic interaction of the metal oxide layer with the protein. Hydrophobicity of the polymer-like film resulted in a higher fibrinogen binding than the silicalike films.

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Titanium modified with layer-by-layer sol–gel tantalum oxide and an organodiphosphonic acid: A coating for hydroxyapatite growth

Cited by 48 publications

References 32 publications

Surface Properties and MC3T3-E1 Cell Response of Cortical Bone Allografts Modified with Low-Concentration Phosphoric Acid

Surface Properties and MC3T3-E1 Cell Response of Cortical Bone Allografts Modified with Low-Concentration Phosphoric Acid

Bilayers coating on titanium surface: The impact on the hydroxyapatite initiation

Interaction of Plasma Deposited HMDSO-Based Coatings with Fibrinogen and Human Blood Plasma: The Correlation between Bulk Plasma, Surface Characteristics and Biomolecule Interaction

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