Titanium mesh-reinforced calcium sulfate for structural bone grafts

Cavelier, Sacha; Mirmohammadi, Seyed Alireza; Barthelat, François

doi:10.1016/j.jmbbm.2021.104461

Cited by 13 publications

(3 citation statements)

References 54 publications

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“…If the porosity is too high, the compressive property and strength of the implant will be reduced, and it would be di cult to bear the stress of the bone resulting in a shortened service life. If the porosity is too low, it will hinder the material exchange of cells and affect the osteogenic ability [36,37]. The porosity of the titanium mesh is not certain, but is closely related to the design of the pore size and shape of the titanium mesh.…”

Section: Discussionmentioning

confidence: 99%

The 3D printed titanium mesh with high porosity has better repair effects than that with low porosity

Liu

Zhou

et al. 2022

Preprint

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Background Most patients with insufficient bone mass suffer from severe horizontal or vertical bone defects in oral implant surgery. The purpose of this study was to compare the bone regeneration effects of titanium mesh with different porosity in the treatment of bone defects. Methods Nine beagle dogs were equally divided into three groups. Three months after the extraction of the first to fourth premolars of the mandible, three bone defects were randomly selected in the mandible. Bone particles and three kinds of 3D printed titanium nets with different porosity (low porosity group, 55%; medium porosity group, 62%; and high porosity group, 68%) were replanted in situ. Beagle dogs were killed 4, 8, and 12 weeks after surgery. Formalin fixed specimens were embedded in acrylic resin. The specimens were stained with micro CT and hard tissue grinding. Results microCT analysis showed that the trabecular thickness, trabecular number, and bone volume fraction of the high porosity group were higher than those of the other two groups. Moreover, the trabecular separation of the high porosity group decreased slightly at any time and was lower than that of the medium porosity and low porosity groups. Histological staining analysis showed that the trabecular number in the high porosity group was higher than in the other two groups at 8 and 12 weeks, and the bone volume fraction was higher than that in the other two groups at 12 weeks. Moreover, the TB. Thmp was higher than that of the LP group at 12 weeks and the trabecular separation was lower in the high porosity group at 4 and 8 weeks. The differences were statistically significant (P < 0.05). Conclusions 3D printed titanium mesh with high porosity in a certain range may have more advantages than titanium mesh with low porosity in repairing large bone defects.

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Section: Discussionmentioning

confidence: 99%

The 3D printed titanium mesh with high porosity has better repair effects than that with low porosity

Liu

Zhou

et al. 2022

Preprint

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“…However, to manufacture the numerically designed scaffolds, innovative technologies and new biocompatible materials are needed to accelerate the development of available grafting techniques. The traditional orthopedic biomaterial is titanium (Ti), which is biocompatible and strong, but this metal is much stiffer than bone (leading to stress shielding) and does not resorb [ 20 ]. While the cortical tissue has an elasticity modulus between 17 and 20 MPa, Ti has an elasticity modulus around 110 GPa.…”

Section: Introductionmentioning

confidence: 99%

The Role of Substrate Topography and Stiffness on MSC Cells Functions: Key Material Properties for Biomimetic Bone Tissue Engineering

et al. 2021

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The hypothesis of the present research is that by altering the substrate topography and/or stiffness to make it biomimetic, we can modulate cells behavior. Substrates with similar surface chemistry and varying stiffnesses and topographies were prepared. Bulk PCL and CNTs-reinforced PCL composites were manufactured by solvent casting method and electrospinning and further processed to obtain tunable moduli of elasticity in the range of few MPa. To ensure the same chemical profile for the substrates, a protein coating was added. Substrate topography and properties were investigated. Further on, the feedback of Wharton’s Jelly Umbilical Cord Mesenchymal Stem Cells to substrates characteristics was investigated. Solvent casting scaffolds displayed superior mechanical properties compared to the corresponding electrospun films. However, the biomimetic fibrous texture of the electrospun substrates induced improved feedback of the cells with respect to their viability and proliferation. Cells’ adhesion and differentiation was remarkably pronounced on solvent casting substrates compared to the electrospun substrates. Soft substates improved cells multiplication and migration, while stiff substrates induced differentiation into bone cells. Aspects related to the key factors and the ideal properties of substrates and microenvironments were clarified, aiming towards the deep understanding of the required optimum biomimetic features of biomaterials.

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“…More importantly, repairing bone defects after surgical resection promotes early functional recovery. A systematic PubMed search revealed several previously reported potent options for bone reconstruction, including cement filling technology (4), autogenous vascularized or nonvascularized bone grafting technology (14)(15)(16), allogenous bone grafting (17), bone transport (Ilizarov technique) (18, 19), bone regeneration induced by a biological membrane (Masquelet technique) (20), mental augmentation with or without stem extension (21), titanium mesh (22), and a promising advancement of three-dimensional (3D) printed microporous implants (23). To the best of our knowledge, the interventions for bone defects vary depending on the lesion site, defect length, patient status, and medical therapeutic skills.…”

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confidence: 99%

Successful management of a rare radius schwannoma mimicking malignant bone tumors: A case report and literature review

Sun

Khan²,

Zeng³

et al. 2023

Front. Surg.

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BackgroundSchwannomas are benign tumors originating from Schwann cells, frequently occurring in the spinal cord and peripheral nerves. Intraosseous schwannomas, a rare subset, account for approximately 0.2% of schwannomas. Intraosseous schwannomas commonly impinge the mandible, followed by the sacrum and the spine. By far, only three cases of radius intraosseous schwannomas have been reported in PubMed. The tumor was treated differently in all three cases, resulting in different outcomes.Case presentationA 29-year-old male construction engineer who complained of a painless mass on the radial aspect of the right forearm was diagnosed with an intraosseous schwannoma of the radius based on radiography, three-dimensional computed tomography reconstruction, magnetic resonance imaging, pathological examination, and immunohistochemistry. A different surgical approach was employed to reconstruct the radial graft defect using bone microrepair techniques, resulting in more reliable bone healing and early functional recovery. Meanwhile, no clinical and radiographic findings suggestive of recurrence were observed at the 12-month follow-up.ConclusionVascularized bone flap transplantation combined with three-dimensional imaging reconstruction planning might yield better results for repairing small segmental bone defects of the radius caused by intraosseous schwannomas.

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Titanium mesh-reinforced calcium sulfate for structural bone grafts

Cited by 13 publications

References 54 publications

The 3D printed titanium mesh with high porosity has better repair effects than that with low porosity

The 3D printed titanium mesh with high porosity has better repair effects than that with low porosity

The Role of Substrate Topography and Stiffness on MSC Cells Functions: Key Material Properties for Biomimetic Bone Tissue Engineering

Successful management of a rare radius schwannoma mimicking malignant bone tumors: A case report and literature review

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