Titanium implant osseointegration with calcium pyrophosphate in rabbits

Koo, Samuel; König, Bruno; Allegrini, Sérgio; Yoshimoto, Marcelo; Carbonari, Marcelo José; Mitri-Luiz, Fábio Franceschini

doi:10.1002/jbm.b.30383

Cited by 12 publications

(10 citation statements)

References 65 publications

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“…In addition, the extracts from Ca-P2 have the best cell proliferation after 7 days (p o0.05). CPP based ceramics have been reported to be potential bone repairing materials with higher biodegradation than HA in vivo and possibility to intensify osteoblast differentiation via releasing Ca 2 þ and PO 4 3 À [14,15]. Therefore our finding is in agreement with these reports.…”

Section: Resultssupporting

confidence: 93%

Microwave hydrothermal synthesis of calcium phosphates using inorganic condensed phosphate salts as precursors

et al. 2016

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a b s t r a c tAs a potential phosphate source, inorganic soluble condensed phosphate salts represent a viable alternative to both orthophosphate and organic condensed phosphate salts. The present work demonstrates a simple but versatile microwave hydrothermal method to prepare calcium phosphates using pyrophosphate and tripolyphosphate salts. After 5-min microwave heating, white fine powders are precipitated from calcium and condensed phosphate containing solution. The as-synthesized precipitates are crystallized calcium pyrophosphate hydrate whiskers and calcium tripolyphosphate hydrate porous microspheres. After calcination, both ceramics are converted into calcium pyrophosphate. In vitro study reveals both precipitates and calcined powders are cytocompatible compared to microwave hydrothermally synthesized hydroxyapatite. With all of these attributes, it is expected different inorganic soluble condensed phosphate salts together with microwave can be used to generate a series of calcium phosphates with unique features.

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Section: Resultssupporting

confidence: 93%

Microwave hydrothermal synthesis of calcium phosphates using inorganic condensed phosphate salts as precursors

et al. 2016

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“…In particular, the sulphonate compound, that is water soluble, is widely used to evaluate mineralized nodule formation in vitro 24. On the other hand, the Alizarin complexone is a fluorochrome, and it is used for bone staining in vivo, and in studies on bone remodeling 25–28…”

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confidence: 99%

The natural compound Alizarin as an osteotropic drug for the treatment of bone tumors

Fotia

Avnet

Granchi

et al. 2012

Journal Orthopaedic Research

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Despite significant clinical improvements, conventional therapies for bone cancer treatment are limited by significant systemic toxicity and lack of specific targeting. In this study, we considered Alizarin, a natural hydroxyanthraquinone derived from madder root with high affinity to calcium and remarkable osteotropic features, as a novel approach for bone cancer treatment. Due to its antitumor properties, as demostrated in colon cancer cells, and to its tropism to bone, Alizarin may be an ideal drug to reduce bone tumor growth. We demonstrated that low dosages of Alizarin strongly inhibited the osteosarcoma (IC 50 for Saos-2, MG-63, and U-2 OS cells, 27.5, 29.0, and 69.9 mg/ml, respectively) and breast carcinoma (IC 50 for MDA-MB-231 cells, 62.1 mg/ml) cell proliferation in vitro. Importantly, Alizarin had a significantly lower inhibitory activity on normal cells (IC 50 for MSC, 828.6 mg/ml), thereby revealing a selective activity towards malignant cells. Furthermore, we found that Alizarin acted through the inhibition of ERK phosphorylation and cell cycle arrest in the S-phase. Finally, Alizarin significantly and strongly impaired both osteosarcoma and breast cancer tumorigenesis. Our results highlight a selective and effective inhibitory activity of Alizarin towards cancerous cells, laying the basis for further studies to investigate its application in bone cancer therapy.

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“…[18] Recently, pyrophosphate ceramics have gained much attention as a biodegradable bone substitute. [19,20] Calcium pyrophosphate (Ca 2 P 2 O 7 ; CP) has a Ca/P ratio of 1.0 and a higher solubility than TCP. [21] It has also been reported that presence of CP A novel biphasic calcium phosphate ceramic composed of tricalcium phosphate (TCP) and calcium pyrophosphate (CP) is synthesized in order to tailor the biodegradation behavior of the ceramic.…”

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confidence: 99%

Biphasic Resorbable Calcium Phosphate Ceramic for Bone Implants and Local Alendronate Delivery

Banerjee¹,

Bandyopadhyay²,

Bose³

2010

Adv Eng Mater

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A novel biphasic calcium phosphate ceramic composed of tricalcium phosphate (TCP) and calcium pyrophosphate (CP) is synthesized in order to tailor the biodegradation behavior of the ceramic. The results show that biphasic TCP/CP ceramic has a strength of 62.2 ± 2.1 MPa, which is superior to single‐phase TCP and CP ceramics, which show strengths of 44.3 ± 3.0 and 53.0 ± 4.8 MPa, respectively. In addition, biphasic TCP/CP ceramic displays a controlled strength degradation from 62.2 ± 2.1 to 40.5 ± 1.0 MPa in stimulated body fluid over a period of 28 d. An in vitro cell materials interaction study using human fetal osteoblast cells indicates that TCP/CP ceramic is cytocompatible. TCP/CP ceramic also show a good loading capacity for alendronate. Adsorption of alendronate (AD) on the TCP/CP surface is found to proceed via ligand exchange mechanism and the in vitro release profile of AD from TCP/CP surface is characterized by an initial fast release followed by a slow and sustained release. Strong electrostatic interactions between AD groups and surface Ca2+ ions enable the slow and sustained release of AD. These results demonstrate that the newly developed biphasic ceramic, with its controlled strength degradation and drug release, shows promise for use in orthopedic and tissue engineering applications.

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Titanium implant osseointegration with calcium pyrophosphate in rabbits

Cited by 12 publications

References 65 publications

Microwave hydrothermal synthesis of calcium phosphates using inorganic condensed phosphate salts as precursors

Microwave hydrothermal synthesis of calcium phosphates using inorganic condensed phosphate salts as precursors

The natural compound Alizarin as an osteotropic drug for the treatment of bone tumors

Biphasic Resorbable Calcium Phosphate Ceramic for Bone Implants and Local Alendronate Delivery

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