Titanium exposure and human health

Tibau, Anita V.; Grube, Blanche D; Velez, Braulio J.; Vega, Víctor M.; Mutter, Joachim

doi:10.1002/osi2.1001

Cited by 21 publications

(8 citation statements)

References 63 publications

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“…Due to the widespread use of TiO 2 , exposure to NPs by ingestion, inhalation, or sorption has become virtually inevitable. In the last five years, reviews have been published on the effects of TiO 2 NPs in living organisms, focusing either on the toxicology of TiO 2 NPs [ 1 , 2 , 11 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ], safety concerns in various applications [ 24 , 25 , 26 , 27 , 28 ] and related impact on human health [ 28 , 29 , 30 , 31 , 32 , 33 ], or their effects on water/soil/environmental quality [ 34 , 35 , 36 , 37 , 38 ]. Such review studies are necessary to conclusively determine the environmental and human effects of TiO 2 NPs.…”

Section: Introductionmentioning

confidence: 99%

Influence of Titanium Dioxide Nanoparticles on Human Health and the Environment

2021

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Nanotechnology has enabled tremendous breakthroughs in the development of materials and, nowadays, is well established in various economic fields. Among the various nanomaterials, TiO2 nanoparticles (NPs) occupy a special position, as they are distinguished by their high availability, high photocatalytic activity, and favorable price, which make them useful in the production of paints, plastics, paper, cosmetics, food, furniture, etc. In textiles, TiO2 NPs are widely used in chemical finishing processes to impart various protective functional properties to the fibers for the production of high-tech textile products with high added value. Such applications contribute to the overall consumption of TiO2 NPs, which gives rise to reasonable considerations about the impact of TiO2 NPs on human health and the environment, and debates regarding whether the extent of the benefits gained from the use of TiO2 NPs justifies the potential risks. In this study, different TiO2 NP exposure modes are discussed, and their toxicity mechanisms—evaluated in various in vitro and in vivo studies—are briefly described, considering the molecular interactions with human health and the environment. In addition, in the conclusion of this study, the toxicity and biocompatibility of TiO2 NPs are discussed, along with relevant risk management strategies.

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Section: Introductionmentioning

confidence: 99%

Influence of Titanium Dioxide Nanoparticles on Human Health and the Environment

2021

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“…Ti is often used in dental implants and other biomedical devices, owing to its reputation as a relatively inert metal. However, harmful reactions in humans (including hypersensitivity and allergic reactions such as facial eczema) can occur as a result of device failure [ 50 ]. In this study, concentrations between 29.7 (P6, whey) and 2313.7 (P34, whey) µg Ti·kg −1 were recorded in samples, with exposures of 0.01–0.99 µg·day −1 , based on a single serving of protein powder for a 70 kg person.…”

Section: Resultsmentioning

confidence: 99%

Development, Validation and Application of an ICP-SFMS Method for the Determination of Metals in Protein Powder Samples, Sourced in Ireland, with Risk Assessment for Irish Consumers

et al. 2021

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A method has been developed, optimised and validated to analyse protein powder supplements on an inductively coupled plasma-sector field mass spectrometer (ICP-SFMS), with reference to ICH Guideline Q2 Validation of Analytical Procedures: Text and Methodology. This method was used in the assessment of twenty-one (n = 21) elements (Al, Au, Ba, Be, Bi, Cd, Co, Cr, Cu, Fe, Hg, Li, Mg, Mn, Mo, Pb, Pt, Sn, Ti, Tl, V) to evaluate the safety of thirty-six (n = 36) protein powder samples that were commercially available in the Irish marketplace in 2016/2017. Using the determined concentrations of elements in samples (µg·kg−1), a human health risk assessment was carried out to evaluate the potential carcinogenic and other risks to consumers of these products. While the concentrations of potentially toxic elements were found to be at acceptable levels, the results suggest that excessive and prolonged use of some of these products may place consumers at a slightly elevated risk for developing cancer or other negative health impacts throughout their lifetimes. Thus, the excessive use of these products is to be cautioned, and consumers are encouraged to follow manufacturer serving recommendations.

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“…[ 21 22 ] Titanium dental implants are the most commonly used material in dentistry and is associated with antenna activity and the electromagnetic waves may produce harmful effects. [ 23 ]…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Serum Metal Ion Levels in Dental Implant Patients

Afradh

Gopi

Shanmugasundaram

et al. 2021

Annals of Maxillofacial Surgery

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Introduction: Titanium is the most commonly used bio-inert implant material. Nevertheless, there is a possibility of systemic release of metal ions, which could have clinical implications like implant failure and toxicity. This prospective study focuses on the evaluation of serum metal ion levels in patients receiving dental implants. The aim of the study is to evaluate the release of titanium, aluminium, and vanadium from dental implants by comparing the preoperative and postoperative serum levels of these ions. Methodology: Serum samples were collected from 30 patients undergoing dental implant placement preoperatively and postoperatively at intervals of 6 weeks, 3, 6, and 12 months. These samples were analyzed for titanium, aluminium, and vanadium levels using Inductively Coupled Plasma Optical Emission Spectrometry. The difference in preoperative and postoperative serum levels was measured and statistically analyzed using the paired t -test. Results: There was a slight difference in the postoperative levels of titanium and aluminium (2.30 and 4.07 mg/dl) as compared to the preoperative levels (2.28 and 2.30 mg/dl), which was statistically insignificant ( P > 0.5). The serum levels of vanadium were too insignificant to be detected by the instrument (<0.0088 mg/dl). Discussion: Mild increase in the titanium and aluminium levels in blood serum was noted. These metallic ion levels might increase significantly due to which further clinical research with larger sample sizes and a long-term follow-up period is required to evaluate the clinical effects of metallic ion release from dental implants. There is no significant difference in the serum metal ion levels before and after the implant placement, although a little increase is observed in the aluminium ion levels after the implant placement.

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Titanium exposure and human health

Cited by 21 publications

References 63 publications

Influence of Titanium Dioxide Nanoparticles on Human Health and the Environment

Influence of Titanium Dioxide Nanoparticles on Human Health and the Environment

Development, Validation and Application of an ICP-SFMS Method for the Determination of Metals in Protein Powder Samples, Sourced in Ireland, with Risk Assessment for Irish Consumers

Evaluation of Serum Metal Ion Levels in Dental Implant Patients

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