Titanium dioxide particles modulate epithelial barrier protein, Claudin 7 in asthma

Lee, Yun-Gi; Lee, Sun-Hye; Hong, Jisu; Lee, Pureun‐Haneul; Jang, An‐Soo

doi:10.1016/j.molimm.2021.01.004

Cited by 12 publications

(20 citation statements)

References 33 publications

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“…PM contributes to airway epithelial barrier dysfunction, which results in airway inflammation and responsiveness. 43 …”

Section: Impact Of Environmental Pollutants On Barrier Dysfunction In Respiratory Diseasementioning

confidence: 99%

“…CLDN7 expression was suppressed by exposure to TiO 2 , suggesting that PM contributes to airway epithelial barrier dysfunction, and results in airway inflammation and responsiveness. 43 CLDN4, 5, and 17 were affected in the nose and lung of mice exposed to diesel exhaust particles, 43 suggesting that cell barrier integrity changed similarly between the upper and lower airways; this raises the possibility that modulation of cell barriers in the nose and lung could be a useful alternative treatment for airway disease. 52 …”

Section: Impact Of Environmental Pollutants On Barrier Dysfunction In Respiratory Diseasementioning

confidence: 99%

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The Impact of Environmental Pollutants on Barrier Dysfunction in Respiratory Disease

Lee

Park

Lee

et al. 2021

Allergy Asthma Immunol Res

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“…PM contributes to airway epithelial barrier dysfunction, which results in airway inflammation and responsiveness. 43 …”

Section: Impact Of Environmental Pollutants On Barrier Dysfunction In Respiratory Diseasementioning

confidence: 99%

Section: Impact Of Environmental Pollutants On Barrier Dysfunction In Respiratory Diseasementioning

confidence: 99%

The Impact of Environmental Pollutants on Barrier Dysfunction in Respiratory Disease

Lee

Park

Lee

et al. 2021

Allergy Asthma Immunol Res

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“…The TJ proteins known as claudins (CLDNs) are important regulators of paracellular permeability. PM exacerbates airway epithelial barrier dysfunction and leads to airway inflammation [ 121 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, this effect was attenuated when TiO 2 and HDM extracts were co-administered. These data suggest that PM exacerbates airway epithelial barrier dysfunction and leads to airway inflammation [ 121 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Air Pollutants on Airway Diseases

Lee

Choi

et al. 2021

IJERPH

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Air pollutants include toxic particles and gases emitted in large quantities from many different combustible materials. They also include particulate matter (PM) and ozone, and biological contaminants, such as viruses and bacteria, which can penetrate the human airway and reach the bloodstream, triggering airway inflammation, dysfunction, and fibrosis. Pollutants that accumulate in the lungs exacerbate symptoms of respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). Asthma, a heterogeneous disease with complex pathological mechanisms, is characterized by particular symptoms such as shortness of breath, a tight chest, coughing, and wheezing. Patients with COPD often experience exacerbations and worsening of symptoms, which may result in hospitalization and disease progression. PM varies in terms of composition, and can include solid and liquid particles of various sizes. PM concentrations are higher in urban areas. Ozone is one of the most toxic photochemical air pollutants. In general, air pollution decreases quality of life and life expectancy. It exacerbates acute and chronic respiratory symptoms in patients with chronic airway diseases, and increases the morbidity and risk of hospitalization associated with respiratory diseases. However, the mechanisms underlying these effects remain unclear. Therefore, we reviewed the impact of air pollutants on airway diseases such as asthma and COPD, focusing on their underlying mechanisms.

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“…Claudins, another type of tight junctions, are also altered by PM (all particle sizes) exposure in mice. Claudin 7 expression was increased in asthmatic mice exposed to PM involving them in the maintenance of epithelial barrier integrity [112]. Secondly, PM 2.5 and PM 10 will induce the production of ROS (oxidative stress) by leading to activation of the NLRP3 inflammasome [18,113].…”

Section: Particulate Mattermentioning

confidence: 99%

Air Pollution and the Airways: Lessons from a Century of Human Urbanization

et al. 2021

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Since the industrial revolution, air pollution has become a major problem causing several health problems involving the airways as well as the cardiovascular, reproductive, or neurological system. According to the WHO, about 3.6 million deaths every year are related to inhalation of polluted air, specifically due to pulmonary diseases. Polluted air first encounters the airways, which are a major human defense mechanism to reduce the risk of this aggressor. Air pollution consists of a mixture of potentially harmful compounds such as particulate matter, ozone, carbon monoxide, volatile organic compounds, and heavy metals, each having its own effects on the human body. In the last decades, a lot of research investigating the underlying risks and effects of air pollution and/or its specific compounds on the airways, has been performed, involving both in vivo and in vitro experiments. The goal of this review is to give an overview of the recent data on the effects of air pollution on healthy and diseased airways or models of airway disease, such as asthma or chronic obstructive pulmonary disease. Therefore, we focused on studies involving pollution and airway symptoms and/or damage both in mice and humans.

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Titanium dioxide particles modulate epithelial barrier protein, Claudin 7 in asthma

Cited by 12 publications

References 33 publications

The Impact of Environmental Pollutants on Barrier Dysfunction in Respiratory Disease

The Impact of Environmental Pollutants on Barrier Dysfunction in Respiratory Disease

Effects of Air Pollutants on Airway Diseases

Air Pollution and the Airways: Lessons from a Century of Human Urbanization

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