Titanium dioxide nanotubes incorporated gellan gum bio-nanocomposite film for wound healing: Effect of TiO2 nanotubes concentration

Razali, Mohd Hasmizam; Ismail, Noor Azizi; Amin, Khairul Anuar Mat

doi:10.1016/j.ijbiomac.2019.10.242

Cited by 67 publications

(28 citation statements)

References 49 publications

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“…Multiple studies were conducted towards the development of a novel class of antibacterial materials that meet the mandatory requirements (e.g., biocompatibility, non-toxicity, superior mechanical properties) [ 33 ] and also have a bactericidal action that is not based on antibiotics. One approach consists in the use of a natural polymer which ensures the biocompatibility and serves as a solid support for inorganic NPs together with metal or metal oxides nanoparticles (Au, Ag, ZnO, TiO 2 , CuO) as active antimicrobial fillers [ 34 , 35 , 36 , 37 , 38 , 39 ]. Regarding the natural polymer, bacterial cellulose is a promising option due to its high purity, biodegradability, non-toxicity, high water uptake ability and 3D porous structure that gives it the capacity to retain excess exudates while maintaining an optimal moisture level at the wound site [ 40 ].…”

Section: Antibacterial Nanocellulose-metal Oxides Hybridsmentioning

confidence: 99%

Nanocellulose Hybrids with Metal Oxides Nanoparticles for Biomedical Applications

Oprea

Panaitescu

2020

Molecules

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Cellulose is one of the most affordable, sustainable and renewable resources, and has attracted much attention especially in the form of nanocellulose. Bacterial cellulose, cellulose nanocrystals or nanofibers may serve as a polymer support to enhance the effectiveness of metal nanoparticles. The resultant hybrids are valuable materials for biomedical applications due to the novel optical, electronic, magnetic and antibacterial properties. In the present review, the preparation methods, properties and application of nanocellulose hybrids with different metal oxides nanoparticles such as zinc oxide, titanium dioxide, copper oxide, magnesium oxide or magnetite are thoroughly discussed. Nanocellulose-metal oxides antibacterial formulations are preferred to antibiotics due to the lack of microbial resistance, which is the main cause for the antibiotics failure to cure infections. Metal oxide nanoparticles may be separately synthesized and added to nanocellulose (ex situ processes) or they can be synthesized using nanocellulose as a template (in situ processes). In the latter case, the precursor is trapped inside the nanocellulose network and then reduced to the metal oxide. The influence of the synthesis methods and conditions on the thermal and mechanical properties, along with the bactericidal and cytotoxicity responses of nanocellulose-metal oxides hybrids were mainly analyzed in this review. The current status of research in the field and future perspectives were also signaled.

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Section: Antibacterial Nanocellulose-metal Oxides Hybridsmentioning

confidence: 99%

Nanocellulose Hybrids with Metal Oxides Nanoparticles for Biomedical Applications

Oprea

Panaitescu

2020

Molecules

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“…Moreover, in an open-excision-type wound-healing study in adult Sprague Dawley rat, the hybrid film promoted an accelerated re-epithelialization (more than 50% on day 3 of wound operation) without inflammatory phenomenon after 14 days of evaluation in comparison with a gellan gum-based film. This phenomenon could be related to the presence of nano-TiO 2 in the polymeric matrix, which was able to promote cell growth and cell migration to accelerate open-excision wound healing, mainly by TiO 2 , which may affect protein interaction and subsequent cell adhesion and proliferation; nonetheless, the acceleration of the wound-healing process may be related to the antimicrobial properties of the hybrid film [38,112].…”

Section: Biomedical Applications Of Nonconventional Polysaccharides Fmentioning

confidence: 99%

Use of Titanium Dioxide (TiO2) Nanoparticles as Reinforcement Agent of Polysaccharide-Based Materials

et al. 2020

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In recent years, a strong interest has emerged in polysaccharide-hybrid composites and their potential applications, which have interesting functional and technological properties. This review summarizes and discusses the reported advantages and limitations of the functionalization of conventional and nonconventional polysaccharides by adding TiO2 nanoparticles as a reinforcement agent. Their effects on the mechanical, thermal, and UV-barrier properties as well as their water-resistance are discussed. In general, the polysaccharide–TiO2 hybrid materials showed improved physicochemical properties in a TiO2 content-dependent response. It showed antimicrobial activity against bacteria (gram-negative and gram-positive), yeasts, and molds with enhanced UV-protective effects for food and non-food packaging purposes. The reported applications of functionalized polysaccharide–TiO2 composites include photocatalysts (dye removal from aqueous media and water purification), biomedical (wound-healing material, drug delivery systems, biosensor, and tissue engineering), food preservation (fruits and meat), cosmetics (sunscreen and bleaching tooth treatment), textile (cotton fabric self-cleaning), and dye-sensitized solar cells. Furthermore, the polysaccharide–TiO2 showed high biocompatibility without adverse effects on different cell lines, indicating that their use in food, pharmaceutical, and biomedical applications is safe. However, it is necessary to evaluate the structural changes promoted by the storage conditions (time and temperature) on the physicochemical properties of polysaccharide–TiO2 hybrid composites to guarantee their stability during a determined time.

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“…Titanium dioxide (TiO 2 ) has been attracting scientific interests due to its spectacular activity on photodegrading contaminants from the environment. Its ability of photodecomposing pollutants, especially organic dyes such as rhodamine B, methylene blue, or crystal violet, has been ameliorated by modification in many sides: forms (nanoparticles to nanotubes [24,25] or nanowires [26]), composition (metals and metal oxide doping [27,28], organodoping [29]), and structure optimization [30]. TiO 2 nanotubes have been demonstrated possessing higher specific surface area, with an orderly one-dimensional structure, comparing with nanoparticles, providing great contribution to its photocatalytic activity.…”

Section: Introductionmentioning

confidence: 99%

Gamma Irradiation-Assisted Synthesis of Silver Nanoparticle-Embedded Graphene Oxide-TiO2 Nanotube Nanocomposite for Organic Dye Photodegradation

Nguyen

2021

Journal of Nanomaterials

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In this work, silver nanoparticle- (AgNP-) embedded graphene oxide- (GO-) TiO2 nanotube (TNT) nanocomposite (labelled GAT) was successfully synthesized by gamma ray radiolysis. The influence of irradiation process, including one-step and two-step assistances and at different irradiation doses (5, 10, 15, 20, and 25 kGy), on the GAT’s physicochemical properties was achieved. Structure and properties of irradiated materials were analyzed by Fourier-transformed infrared (FT-IR), ultraviolet-visible absorption (UV-Vis), and Raman spectroscopies; X-ray diffraction (XRD); and scanning electron (SEM) and transmission electron (TEM) microscopies. In addition, selective scavengers of e-aq and ⋅OH radicals were used to investigate the radiolytic synthesis of GAT nanocomposite. It was revealed that gamma ray irradiation could strongly support the relation of the composite synthesis. Furthermore, the synthesized GAT nanocomposites showed a significant effect for Rhodamine B (RhB) photodecomposition after 60 minutes of natural sunlight exposure and evaluation by UV-Vis absorption spectroscopy. Briefly, the obtained results highlighted the potential of gamma irradiation as a “clean” and controllable way for synthesizing beneficial nanocomposite materials for wastewater purification and other environmental aspects.

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Titanium dioxide nanotubes incorporated gellan gum bio-nanocomposite film for wound healing: Effect of TiO2 nanotubes concentration

Cited by 67 publications

References 49 publications

Nanocellulose Hybrids with Metal Oxides Nanoparticles for Biomedical Applications

Nanocellulose Hybrids with Metal Oxides Nanoparticles for Biomedical Applications

Use of Titanium Dioxide (TiO2) Nanoparticles as Reinforcement Agent of Polysaccharide-Based Materials

Gamma Irradiation-Assisted Synthesis of Silver Nanoparticle-Embedded Graphene Oxide-TiO2 Nanotube Nanocomposite for Organic Dye Photodegradation

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