Titanium-containing bioactive phosphate glasses

Kiani, Azadeh; Lakhkar, Nilay J.; Salih, Vehid; Smith, Mark E.; Hanna, John V.; Newport, Robert J.; Pickup, David M.; Knowles, Jonathan C.

doi:10.1098/rsta.2011.0276

Cited by 44 publications

(31 citation statements)

References 114 publications

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“…The ability to introduce new oxides to the basic sodium-calcium phosphate glass network is of great interest as it allows properties such as their dissolution rates to be tailored (see for example works studying the effect of MgO [10], TiO 2 [11] and Fe 2 O 3 [12]) and the addition of therapeutic ions for controlled release into the body [13].…”

Section: Introductionmentioning

confidence: 99%

Structural and physico-chemical analysis of calcium/strontium substituted, near-invert phosphate based glasses for biomedical applications

Patel¹,

Moss²,

Hossain³

et al. 2017

Acta Biomaterialia

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Neutron diffraction, 23 Na and 31 P NMR and FTIR spectroscopy have been used to investigate the structural effects of substituting CaO with SrO in a 40P 2 O 5 ·(16-x)CaO·20Na 2 O·24MgO·xSrO glass, where x is 0, 4, 8, 12 and 16 mol%. The 31 P solid-state NMR results showed similar amounts of Q 1 and Q 2 units for all of the multicomponent glasses investigated, showing that the substitution of Sr for Ca has no effect on the phosphate network. The M-O coordinations (M= Mg, Ca, Sr, Na) were determined for binary alkali and alkaline earth metaphosphates using neutron diffraction and broad asymmetric distributions of bond length were observed, with coordination numbers that were smaller and bond lengths that were shorter than in corresponding crystals. The Mg-O coordination number was determined most reliably as 5.0(2). The neutron diffraction results for the multicomponent glasses are consistent with a structural model in which the coordination of Ca, Sr and Na is the same as in the binary metaphosphate glass, whereas there is a definite shift of Mg-O bonds to longer distance. There is also a small but consistent increase in the Mg-O coordination number and the width of the distribution of Mg-O bond lengths, as Sr substitutes for Ca. Functional properties, including glass transition temperatures, thermal processing windows, dissolution rates and ion release profiles were also investigated. Dissolution studies showed a decrease in dissolution rate with initial addition of 4 mol% SrO, but further addition of SrO showed little change. The ion release profiles followed a similar trend to the dissolution rates observed. The limited changes in structure and dissolution rates observed for substitution of Ca with Sr in these fixed 40 mol% P 2 O 5 glasses were attributed to their similarities in terms of ionic size and charge.

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Section: Introductionmentioning

confidence: 99%

Structural and physico-chemical analysis of calcium/strontium substituted, near-invert phosphate based glasses for biomedical applications

Patel¹,

Moss²,

Hossain³

et al. 2017

Acta Biomaterialia

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“…FTIR analysis showed that the infrared spectra of the hybrid fibers after their deposition by electrospinning exhibited the characteristic absorbance peaks of PLA and additional signals related to phosphate complexes ( Figure 5). The PO 4 3-tetrahedron, the basic building block of phosphatebased glasses, 28,42 is present in the fibers, as represented by the absorbance observed at numerous wavelengths. P-O-P stretching modes are also clearly visible on the spectrum.…”

mentioning

confidence: 99%

“…These ORMOGLASSES, however, favor cell attachment, proliferation, and differentiation. 42 It is thus already commonly accepted that such bioactive glasses should rather be used with cells than for an efficient mineralization. 42,57 In fact, Monem et al demonstrated that it is not necessary to require a chemical link between calcium phosphate compounds and the host tissue, because other variables of the material may also promote bone growth.…”

mentioning

confidence: 99%

“…42 It is thus already commonly accepted that such bioactive glasses should rather be used with cells than for an efficient mineralization. 42,57 In fact, Monem et al demonstrated that it is not necessary to require a chemical link between calcium phosphate compounds and the host tissue, because other variables of the material may also promote bone growth. 58 Novel fibrous mats described in this study are aimed to be used as substrates for the triggering of specific cellular activity either in cellular or in acellular tissue engineering approaches, and not to be used for improving implant integration.…”

mentioning

confidence: 99%

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Fast-degrading PLA/ORMOGLASS fibrous composite scaffold leads to a calcium-rich angiogenic environment

Sachot¹,

Roguska²,

Planell³

et al. 2017

IJN

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The success of scaffold implantation in acellular tissue engineering approaches relies on the ability of the material to interact properly with the biological environment. This behavior mainly depends on the design of the graft surface and, more precisely, on its capacity to biodegrade in a well-defined manner (nature of ions released, surface-to-volume ratio, dissolution profile of this release, rate of material resorption, and preservation of mechanical properties). The assessment of the biological behavior of temporary templates is therefore very important in tissue engineering, especially for composites, which usually exhibit complicated degradation behavior. Here, blended polylactic acid (PLA) calcium phosphate ORMOGLASS (organically modified glass) nanofibrous mats have been incubated up to 4 weeks in physiological simulated conditions, and their morphological, topographical, and chemical changes have been investigated. The results showed that a significant loss of inorganic phase occurred at the beginning of the immersion and the ORMOGLASS maintained a stable composition afterward throughout the degradation period. As a whole, the nanostructured scaffolds underwent fast and heterogeneous degradation. This study reveals that an angiogenic calcium-rich environment can be achieved through fast-degrading ORMOGLASS/PLA blended fibers, which seems to be an excellent alternative for guided bone regeneration.

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“…This has involved both theoretical methods as well as experimental approaches. Here, Kiani et al [73] discuss the range of techniques that have been used to elucidate the structure of phosphate glasses, focusing on the network connectivity information which can be obtained from two-dimensional magic angle spinning (MAS) NMR correlation experiments. They show how this has led to progress in the processing of these glasses, by describing the structural chemistry of titanium dopants in phosphate glasses.…”

Section: Need For a More Rational Approachmentioning

confidence: 99%

Structure and biological activity of glasses and ceramics

Cormack

Tilocca

2012

Phil. Trans. R. Soc. A.

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Biomaterials for repairing and regenerating parts of the human body play a key role in contemporary medicine, and have an increasing impact in modern society. Given the importance of orthopaedic medicine (bone is the second most replaced organ after blood), bioactive glasses and ceramics represent a key reference to guide technological advances in this field. Their established role in current biomedical applications has already led many research groups worldwide to look into their structural properties, with a view to identifying the molecular basis of their biological activity. As the efforts directed towards this crucial and exciting direction continue to increase, it is now timely to review the situation, in order to guide future investigations on structure–bioactivity relationships. In this introductory article, the field is reviewed, to provide an appropriate context for the contributions to this Theme Issue.

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Titanium-containing bioactive phosphate glasses

Cited by 44 publications

References 114 publications

Structural and physico-chemical analysis of calcium/strontium substituted, near-invert phosphate based glasses for biomedical applications

Structural and physico-chemical analysis of calcium/strontium substituted, near-invert phosphate based glasses for biomedical applications

Fast-degrading PLA/ORMOGLASS fibrous composite scaffold leads to a calcium-rich angiogenic environment

Structure and biological activity of glasses and ceramics

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