Titanium complexes based on aminodiol ligands for the ring opening polymerization of l- and d,l-lactide

Dakshinamoorthy, Deivasagayam; Peruch, Frédéric

doi:10.1016/j.polymer.2011.07.049

Cited by 27 publications

(27 citation statements)

References 55 publications

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“…33 The obtained % of CL unit in the copolymer was always reduced with respect to the monomer feed (Table 4). This results are in sharp contrast to the results of the homopolymerization of CL and LA (ROP of CL is much faster than the ROP of LA) under the same polymerization condition 29, 30. Nevertheless, such a behavior seems to be a common feature for the random copolymerization of ε‐CL and LA as it has been reported in the literature earlier 9–14, 19.…”

Section: Resultscontrasting

confidence: 75%

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Treatment with lenalidomide modulates T‐cell immunophenotype and cytokine production in patients with chronic lymphocytic leukemia

Lee

Gao

Cohen

et al. 2011

Cancer

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BACKGROUND Lenalidomide, an immunomodulatory agent, has activity in lymphoproliferative disorders. The authors, therefore, evaluated its effects on T-cell immunophenotype and cytokine production in patients with chronic lymphocytic leukemia (CLL). METHODS To study the immunomodulatory effects of lenalidomide in CLL, the authors recruited 24 patients with untreated CLL enrolled in a phase 2 clinical trial of lenalidomide and obtained peripheral blood specimens for immunologic studies consisting of enumeration of T cells and assessing their ability to synthesize cytokines after activation through T-cell receptor (TCR). RESULTS After 3 cycles of therapy, patients had a significant reduction in percentage (%) and absolute lymphocyte count (ALC) and an increase in percentage of T cells, percentage of activated CD8+ T cells producing IFN-γ, and percentage of regulatory T (TR) cells when compared with their respective levels before treatment. After 15 cycles of treatment, responder patients had significant reduction in percentage of lymphocytes and ALC, percentage of activated CD4+ T cells producing IL-2, IFN-γ, or TNF-α, and percentage of TR cells when compared with their perspective levels after 3 cycles of treatment. Furthermore, the numbers of activated CD4+ T cells producing IL-2, IFN-γ, or TNF-α, activated CD8+ T cells producing IFN-γ, and TR cells normalized to the range of healthy subjects. CONCLUSIONS Treatment with lenalidomide resulted in the normalization of functional T-cell subsets in responders, suggesting that lenalidomide may modulate cell-mediated immunity in patients with CLL.

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Section: Resultscontrasting

confidence: 75%

“…13 C NMR spectrum (see Supporting Information Fig. S16) of this copolymer does not show the peak corresponding to CLC sequence, thereby indicating the absence of second mode of transesterification, as transesterification is less prominent in case of L‐LA than DL‐LA 29…”

Section: Resultsmentioning

confidence: 96%

Treatment with lenalidomide modulates T‐cell immunophenotype and cytokine production in patients with chronic lymphocytic leukemia

Lee

Gao

Cohen

et al. 2011

Cancer

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“…This results are in sharp contrast to the results of the homopolymerization of CL and LA (ROP of CL is much faster than the ROP of LA) under the same polymerization condition. 29,30 Nevertheless, such a behavior seems to be a common feature for the random copolymerization of e-CL and LA as it has been reported in the literature earlier. [9][10][11][12][13][14]19 Methylene protons of PCL close to the carbonyl group and at 5.0 ppm as proton (d) for LA-CL heterosequences.…”

Section: Random Copolymerization Of E-cl and Dl-la In Solutionsupporting

confidence: 58%

Block and random copolymerization of ε‐caprolactone, L‐, and rac‐lactide using titanium complex derived from aminodiol ligand

Dakshinamoorthy

Peruch

2012

J. Polym. Sci. A Polym. Chem.

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A series of di‐ and triblock copolymers [poly(L‐lactide‐b‐ε‐caprolactone), poly(D,L‐lactide‐b‐ε‐caprolactone), poly(ε‐caprolactone‐b‐L‐lactide), and poly(ε‐caprolactone‐b‐L‐lactide‐b‐ε‐caprolactone)] have been synthesized successfully by sequential ring‐opening polymerization of ε‐caprolactone (ε‐CL) and lactide (LA) either by initiating PCL block growth with living PLA chain end or vice versa using titanium complexes supported by aminodiol ligands as initiators. Poly(trimethylene carbonate‐b‐ε‐caprolactone) was also prepared. A series of random copolymers with different comonomer composition were also synthesized in solution and bulk of ε‐CL and D,L‐lactide. The chemical composition and microstructure of the copolymers suggest a random distribution with short average sequence length of both the LA and ε‐CL. Transesterification reactions played a key role in the redistribution of monomer sequence and the chain microstructures. Differential scanning calorimetry analysis of the copolymer also evidenced the random structure of the copolymer with a unique Tg. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012

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“…Therefore, the interest in developing biodegradable "green" materials without any environmental pollution is rapidly growing. 3,4 As an environmentally friendly polymer, PLA has been emerging as an alternative to conventional polymeric materials due to its renewability, biodegradability, and greenhouse gas neutrality. 2 A large number of biodegradable polymers exist which can be produced from both natural and synthetic sources.…”

Section: Introductionmentioning

confidence: 99%

The morphology, rheological, and mechanical properties of wood flour/starch/poly(lactic acid) blends

Tan

et al. 2017

J of Applied Polymer Sci

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An entirely biosourced blend composed of poly(lactic acid) (PLA), starch, and wood flour (WF) was prepared by a coextruder with glycerol as a plasticizer. The morphology, rheological properties, and mechanical properties of the WF/starch/PLA blends were comprehensively analyzed. The results showed that with the decrease of the starch/WF ratio, the morphology experienced a large transformation, and the compatibility of the blends was found to be superior to other blends, with a starch/wood flour ratio of 7/3. The dynamic mechanical thermal analysis (DMA) results demonstrated the incompatibility of the components in WF/starch/ PLA blends. Following the decrease of the starch/WF ratio, the storage modulus (G 00 ) and the complex viscosity (h*) of the blends increased. The mechanical strength first increased, and then decreased with the increase of the WF concentration. The water absorption results showed that the water resistance of the blends was reduced with the lower starch/WF ratio.

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Titanium complexes based on aminodiol ligands for the ring opening polymerization of l- and d,l-lactide

Cited by 27 publications

References 55 publications

Treatment with lenalidomide modulates T‐cell immunophenotype and cytokine production in patients with chronic lymphocytic leukemia

Treatment with lenalidomide modulates T‐cell immunophenotype and cytokine production in patients with chronic lymphocytic leukemia

Block and random copolymerization of ε‐caprolactone, L‐, and rac‐lactide using titanium complex derived from aminodiol ligand

The morphology, rheological, and mechanical properties of wood flour/starch/poly(lactic acid) blends

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