Titanium‐Based Nanoarchitectures for Sonodynamic Therapy‐Involved Multimodal Treatments

Maleki, Aziz; Seyedhamzeh, Mohammad; Yuan, Meng; Agarwal, Tarun; Sharifi, Ibrahim; Mohammadi, Abbas; Kelicen-Uğur, Pelin; Hamidi, Mehrdad; Malaki, Massoud; Kheraif, Abdulaziz A. Al; Cheng, Ziyong; Lin, Jun

doi:10.1002/smll.202206253

Cited by 26 publications

(9 citation statements)

References 198 publications

(324 reference statements)

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“…Encouraged by the excellent tissue-penetration depth of US and the non-invasiveness during the treatment, SDT shows distinct potential to replace antibiotics treatment and avoid the multiple surgical debridements against osteomyelitis [129] , [130] . Cheng et al reported gold-doped titanate nanotubes conjugated with guanidinium-rich polymer (Au/TNT@PG) for MRSA biofilm elimination by SDT [113] .…”

Section: Applications Of Sdt In Bacterial Infectious Diseasesmentioning

confidence: 99%

Sonodynamic therapy-based nanoplatforms for combating bacterial infections

Xu,

Kumar Kankala,

Wang

et al. 2023

Ultrasonics Sonochemistry

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Section: Applications Of Sdt In Bacterial Infectious Diseasesmentioning

confidence: 99%

Sonodynamic therapy-based nanoplatforms for combating bacterial infections

Xu,

Kumar Kankala,

Wang

et al. 2023

Ultrasonics Sonochemistry

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“…Despite this, it is undeniable that achieving a very successful therapeutic response with monotherapy is typically difficult due to the complex tumor microenvironment. [139][140][141] All known cancer treatments, such as chemotherapy, [142][143][144] chemodynamic therapy, [145][146][147] photodynamic therapy, [148][149][150] photothermal therapy, [151][152][153] and immunotherapy, [154][155][156] have progressed sufficiently independently to significantly complement others. Therefore, many researchers have combined these methods with SDT to improve the overall treatment effect of the disease.…”

Section: Sdt Combined With Other Therapeutic Modalitiesmentioning

confidence: 99%

Improvement of the effectiveness of sonodynamic therapy: by optimizing components and combination with other treatments

Wang,

Xu,

Yang

et al. 2023

Biomater. Sci.

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“…It will greatly reduce the effect of immunotherapy . Besides, the oxygen-dependent treatments, such as photodynamic therapy (PDT) , and sonodynamic therapy, will lose efficacy in the hypoxic environment. Moreover, the oxidative damage to tumor would be reduced, and TME would also cause certain drug resistance .…”

Section: Introductionmentioning

confidence: 99%

Tumor Microenvironment-Regulating Two-Photon Probe Based on Bimetallic Post-Coordinated MOF Facilitating the Dual-Modal and Deep Imaging-Guided Synergistic Therapies

Liu,

Wang,

Zhang

et al. 2024

ACS Appl. Mater. Interfaces

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The intricate tumor microenvironment (TME) always brings about unsatisfactory therapeutic effects for treatments, although nanomedicines have been demonstrated to be highly beneficial for synergistic therapies to avoid the side effects caused by the complexity and heterogeneity of cancer. Developing nanotheranostics with the functionalities of both synergistic therapies and TME regulation is a good strategy but is still in its infancy. Herein, an "all-in-one" nanoplatform for integrated diagnosis and treatment, namely, Carrier@ICG@DOX@FA (CIDF), is constructed. Benefiting from the bimetallic coordination of Eu 3+ -HTHA (4,4,4-trifluoro-1-(9-hexylcarbazol-3-yl)-1,3-butanedione) and Fe 3+ with the ligands in UiO-67, CIDF can simultaneously achieve two-photon fluorescence imaging, fluorescent lifetime imaging in deep tumors, and regulation of TME. Owing to its porosity, CIDF can encapsulate indocyanine green as photosensitizers and doxorubicin as chemotherapeutic agent, further realizing light-controlled drug release. Moreover, CIDF exhibited good biocompatibility and tumor targeting by coating with folic-acid-modified polymers. Both in vitro and in vivo experiments demonstrate the excellent therapeutic efficacy of CIDF through dual-modal-imaging-guided synergistic photothermal-, photodynamic-, and chemotherapy. CIDF provides a new paradigm for the construction of TME-regulated synergistic nanotheranostics and realizes the complete elimination of tumors without recurrence.

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Titanium‐Based Nanoarchitectures for Sonodynamic Therapy‐Involved Multimodal Treatments

Cited by 26 publications

References 198 publications

Sonodynamic therapy-based nanoplatforms for combating bacterial infections

Sonodynamic therapy-based nanoplatforms for combating bacterial infections

Improvement of the effectiveness of sonodynamic therapy: by optimizing components and combination with other treatments

Tumor Microenvironment-Regulating Two-Photon Probe Based on Bimetallic Post-Coordinated MOF Facilitating the Dual-Modal and Deep Imaging-Guided Synergistic Therapies

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